SEC23IP: Difference between revisions
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'''SEC23-interacting protein''' is a [[protein]] that in humans is encoded by the ''SEC23IP'' [[gene]].<ref name="pmid10400679">{{cite journal | vauthors = Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M | title = p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins | journal = J Biol Chem | volume = 274 | issue = 29 | pages = 20505–12 |date=Aug 1999 | pmid = 10400679 | pmc = | doi =10.1074/jbc.274.29.20505 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SEC23IP SEC23 interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11196| accessdate = }}</ref> | '''SEC23-interacting protein''' is a [[protein]] that in humans is encoded by the ''SEC23IP'' [[gene]].<ref name="pmid10400679">{{cite journal | vauthors = Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M | title = p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins | journal = J Biol Chem | volume = 274 | issue = 29 | pages = 20505–12 |date=Aug 1999 | pmid = 10400679 | pmc = | doi =10.1074/jbc.274.29.20505 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SEC23IP SEC23 interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11196| accessdate = }}</ref> | ||
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| summary_text = COPII-coated vesicles are involved in protein transport from the endoplasmic reticulum to the Golgi apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.<ref name="entrez">{{cite web | title = Entrez Gene: SEC23IP SEC23 interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11196| accessdate = }}</ref> | | summary_text = COPII-coated vesicles are involved in [[protein transport]] from the [[endoplasmic reticulum]] to the [[Golgi apparatus]]. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the [[COPII]]. This protein shares significant similarity with phospholipid-modifying proteins, especially [[phosphatidic acid]] preferring-[[phospholipase A1]]. [[Overexpression]] of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early [[secretory pathway]].<ref name="entrez">{{cite web | title = Entrez Gene: SEC23IP SEC23 interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11196| accessdate = }}</ref> | ||
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Latest revision as of 20:48, 19 February 2018
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SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.[1][2]
COPII-coated vesicles are involved in protein transport from the endoplasmic reticulum to the Golgi apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.[2]
References
- ↑ Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M (Aug 1999). "p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins". J Biol Chem. 274 (29): 20505–12. doi:10.1074/jbc.274.29.20505. PMID 10400679.
- ↑ 2.0 2.1 "Entrez Gene: SEC23IP SEC23 interacting protein".
Further reading
- Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta". J. Biol. Chem. 281 (21): 14748–55. doi:10.1074/jbc.M600322200. PMID 16510448.
- Shimoi W, Ezawa I, Nakamoto K, et al. (2005). "p125 is localized in endoplasmic reticulum exit sites and involved in their organization". J. Biol. Chem. 280 (11): 10141–8. doi:10.1074/jbc.M409673200. PMID 15623529.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mizoguchi T, Nakajima K, Hatsuzawa K, et al. (2001). "Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein". Biochem. Biophys. Res. Commun. 279 (1): 144–9. doi:10.1006/bbrc.2000.3846. PMID 11112430.
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