Tweety family member 2: Difference between revisions
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'''Tweety family member 2''' is a [[protein]] that in humans is encoded by the TTYH2 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Tweety family member 2 | url = https://www.ncbi.nlm.nih.gov/gene/94015}}</ref> Members of this family function as [[chloride channel]]s. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney [[tumorigenesis]]. Two transcript variants encoding distinct isoforms have been identified for this gene. | |||
'''Tweety family member 2''' is a [[protein]] that in humans is encoded by the TTYH2 [[gene]]. | |||
<ref name="entrez"> | |||
{{cite web | |||
| title = Entrez Gene: Tweety family member 2 | |||
| url = https://www.ncbi.nlm.nih.gov/gene/94015 | |||
}}</ref> | |||
== References == | == References == | ||
{{reflist}} | {{reflist}} | ||
== Further reading == | == Further reading == | ||
{{refbegin}} | |||
{{refbegin | * {{cite journal | vauthors = Bisson N, James DA, Ivosev G, Tate SA, Bonner R, Taylor L, Pawson T | title = Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor | journal = Nature Biotechnology | volume = 29 | issue = 7 | pages = 653–8 | date = June 2011 | pmid = 21706016 | pmc = | doi = 10.1038/nbt.1905 }} | ||
*{{ | * {{cite journal | vauthors = Ibarrola N, Molina H, Iwahori A, Pandey A | title = A novel proteomic approach for specific identification of tyrosine kinase substrates using [13C]tyrosine | journal = The Journal of Biological Chemistry | volume = 279 | issue = 16 | pages = 15805–13 | date = April 2004 | pmid = 14739304 | doi = 10.1074/jbc.M311714200 }} | ||
| | * {{cite journal | vauthors = Rae FK, Hooper JD, Eyre HJ, Sutherland GR, Nicol DL, Clements JA | title = TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma | journal = Genomics | volume = 77 | issue = 3 | pages = 200–7 | date = October 2001 | pmid = 11597145 | doi = 10.1006/geno.2001.6629 }} | ||
* {{cite journal | vauthors = Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M | title = TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation | journal = World Journal of Gastroenterology | volume = 13 | issue = 19 | pages = 2717–21 | date = May 2007 | pmid = 17569141 | pmc = 4147121 | doi=10.3748/wjg.v13.i19.2717}} | |||
* {{cite journal | vauthors = Suzuki M, Mizuno A | title = A novel human Cl(-) channel family related to Drosophila flightless locus | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 22461–8 | date = May 2004 | pmid = 15010458 | doi = 10.1074/jbc.M313813200 }} | |||
* {{cite journal | vauthors = He Y, Ramsay AJ, Hunt ML, Whitbread AK, Myers SA, Hooper JD | title = N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2) | journal = The Biochemical Journal | volume = 412 | issue = 1 | pages = 45–55 | date = May 2008 | pmid = 18260827 | doi = 10.1042/BJ20071722 }} | |||
* {{cite journal | vauthors = He Y, Hryciw DH, Carroll ML, Myers SA, Whitbread AK, Kumar S, Poronnik P, Hooper JD | title = The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels | journal = The Journal of Biological Chemistry | volume = 283 | issue = 35 | pages = 24000–10 | date = August 2008 | pmid = 18577513 | pmc = 3259790 | doi = 10.1074/jbc.M803361200 }} | |||
| title = Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor | |||
| journal = Nature Biotechnology | |||
| volume = 29 | |||
| issue = 7 | |||
| pages = | |||
| | |||
| pmid = 21706016 | |||
| pmc = | |||
}} | |||
*{{ | |||
| title = A novel proteomic approach for specific identification of tyrosine kinase substrates using | |||
| journal = Journal of Biological Chemistry | |||
| volume = 279 | |||
| issue = 16 | |||
| pages = 15805–13 | |||
| | |||
| | |||
| doi = 10.1074/jbc.M311714200 | |||
}} | |||
*{{ | |||
| | |||
| title = TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma | |||
| journal = Genomics | |||
| volume = 77 | |||
| issue = 3 | |||
| pages = 200–7 | |||
| | |||
| | |||
| doi = 10.1006/geno.2001.6629 | |||
}} | |||
*{{ | |||
| title = TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation | |||
| journal = World Journal of Gastroenterology | |||
| volume = 13 | |||
| issue = 19 | |||
| pages = 2717–21 | |||
| | |||
| | |||
| | |||
| | |||
}} | |||
*{{ | |||
| title = A novel human Cl(-) channel family related to Drosophila flightless locus | |||
| journal = Journal of Biological Chemistry | |||
| volume = 279 | |||
| issue = 21 | |||
| pages = 22461–8 | |||
| | |||
| | |||
| doi = 10.1074/jbc.M313813200 | |||
}} | |||
*{{ | |||
| title = N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: | |||
| journal = Biochemical Journal | |||
| volume = 412 | |||
| issue = 1 | |||
| pages = 45–55 | |||
| | |||
| | |||
| doi = 10.1042/BJ20071722 | |||
}} | |||
*{{ | |||
| | |||
| title = The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels | |||
| journal = Journal of Biological Chemistry | |||
| volume = 283 | |||
| issue = 35 | |||
| pages = 24000–10 | |||
| | |||
| | |||
| | |||
| doi = 10.1074/jbc.M803361200 | |||
}} | |||
{{refend}} | {{refend}} | ||
{{NLM content}} | {{NLM content}} | ||
{{gene-17-stub}} | {{gene-17-stub}} |
Latest revision as of 16:22, 6 February 2018
VALUE_ERROR (nil) | |||||||
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Identifiers | |||||||
Aliases | |||||||
External IDs | GeneCards: [1] | ||||||
Orthologs | |||||||
Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Tweety family member 2 is a protein that in humans is encoded by the TTYH2 gene.[1] Members of this family function as chloride channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene.
References
Further reading
- Bisson N, James DA, Ivosev G, Tate SA, Bonner R, Taylor L, Pawson T (June 2011). "Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor". Nature Biotechnology. 29 (7): 653–8. doi:10.1038/nbt.1905. PMID 21706016.
- Ibarrola N, Molina H, Iwahori A, Pandey A (April 2004). "A novel proteomic approach for specific identification of tyrosine kinase substrates using [13C]tyrosine". The Journal of Biological Chemistry. 279 (16): 15805–13. doi:10.1074/jbc.M311714200. PMID 14739304.
- Rae FK, Hooper JD, Eyre HJ, Sutherland GR, Nicol DL, Clements JA (October 2001). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma". Genomics. 77 (3): 200–7. doi:10.1006/geno.2001.6629. PMID 11597145.
- Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M (May 2007). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation". World Journal of Gastroenterology. 13 (19): 2717–21. doi:10.3748/wjg.v13.i19.2717. PMC 4147121. PMID 17569141.
- Suzuki M, Mizuno A (May 2004). "A novel human Cl(-) channel family related to Drosophila flightless locus". The Journal of Biological Chemistry. 279 (21): 22461–8. doi:10.1074/jbc.M313813200. PMID 15010458.
- He Y, Ramsay AJ, Hunt ML, Whitbread AK, Myers SA, Hooper JD (May 2008). "N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2)". The Biochemical Journal. 412 (1): 45–55. doi:10.1042/BJ20071722. PMID 18260827.
- He Y, Hryciw DH, Carroll ML, Myers SA, Whitbread AK, Kumar S, Poronnik P, Hooper JD (August 2008). "The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels". The Journal of Biological Chemistry. 283 (35): 24000–10. doi:10.1074/jbc.M803361200. PMC 3259790. PMID 18577513.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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