WFIKKN2: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2''' is a [[protein]] that in humans is encoded by the WFIKKN2 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 | url = https://www.ncbi.nlm.nih.gov/gene/124857 }}</ref>


'''WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2''' is a [[protein]] that in humans is encoded by the WFIKKN2 [[gene]].
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
| url = https://www.ncbi.nlm.nih.gov/gene/124857
| accessdate = 2014-03-20 <!-- T13:44:04.018499-08:00 -->
}}</ref>
 
==Function==


The [[WFIKKN1]] protein contains a WAP domain, [[follistatin]] domain, [[immunoglobulin domain]], two tandem [[Kunitz domain]]s, and an [[Netrin|NTR]] domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AY358142.1, AK127743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END##
The [[WFIKKN1]] protein contains a WAP domain, [[follistatin]] domain, [[immunoglobulin domain]], two tandem [[Kunitz domain]]s, and an [[Netrin|NTR]] domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AY358142.1, AK127743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END##


==See also==
== See also ==
*[[Kazal-type serine protease inhibitor domain]]
*[[Kazal-type serine protease inhibitor domain]]


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal
* {{cite journal | vauthors = Szláma G, Kondás K, Trexler M, Patthy L | title = WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity | journal = The FEBS Journal | volume = 277 | issue = 24 | pages = 5040–50 | date = December 2010 | pmid = 21054789 | doi = 10.1111/j.1742-4658.2010.07909.x }}
| pmid = 21054789
* {{cite journal | vauthors = Hill JJ, Qiu Y, Hewick RM, Wolfman NM | title = Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains | journal = Molecular Endocrinology | volume = 17 | issue = 6 | pages = 1144–54 | date = June 2003 | pmid = 12595574 | doi = 10.1210/me.2002-0366 }}
| year = 2010
* {{cite journal | vauthors = Kondás K, Szláma G, Trexler M, Patthy L | title = Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11 | journal = The Journal of Biological Chemistry | volume = 283 | issue = 35 | pages = 23677–84 | date = August 2008 | pmid = 18596030 | pmc = 3259755 | doi = 10.1074/jbc.M803025200 }}
| author1 = Szláma
* {{cite journal | vauthors = Nagy A, Trexler M, Patthy L | title = Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein | journal = European Journal of Biochemistry | volume = 270 | issue = 9 | pages = 2101–7 | date = May 2003 | pmid = 12709070 | doi = 10.1046/j.1432-1033.2003.03593.x }}
| first1 = G
* {{cite journal | vauthors = Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET | title = Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women | journal = Journal of Strength and Conditioning Research | volume = 26 | issue = 5 | pages = 1374–82 | date = May 2012 | pmid = 22395277 | doi = 10.1519/JSC.0b013e318251083f }}
| title = WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity
* {{cite journal | vauthors = Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K | title = Effects of oral creatine and resistance training on serum myostatin and GASP-1 | journal = Molecular and Cellular Endocrinology | volume = 317 | issue = 1–2 | pages = 25–30 | date = April 2010 | pmid = 20026378 | doi = 10.1016/j.mce.2009.12.019 }}
| journal = FEBS Journal
* {{cite journal | vauthors = Trexler M, Bányai L, Patthy L | title = Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules | journal = Biological Chemistry | volume = 383 | issue = 1 | pages = 223–8 | date = January 2002 | pmid = 11928817 | doi = 10.1515/BC.2002.023 }}
| volume = 277
| issue = 24
| pages = 5040–50
| last2 = Kondás
| first2 = K
| last3 = Trexler
| first3 = M
| last4 = Patthy
| first4 = L
| doi = 10.1111/j.1742-4658.2010.07909.x
}}
*{{Cite journal
| pmid = 12595574
| year = 2003
| author1 = Hill
| first1 = J. J.
| title = Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: A novel protein with protease inhibitor and follistatin domains
| journal = Molecular Endocrinology
| volume = 17
| issue = 6
| pages = 1144–54
| last2 = Qiu
| first2 = Y
| last3 = Hewick
| first3 = R. M.
| last4 = Wolfman
| first4 = N. M.
| doi = 10.1210/me.2002-0366
}}
*{{Cite journal
| pmid = 18596030
| year = 2008
| author1 = Kondás
| first1 = K
| title = Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11
| journal = Journal of Biological Chemistry
| volume = 283
| issue = 35
| pages = 23677–84
| last2 = Szláma
| first2 = G
| last3 = Trexler
| first3 = M
| last4 = Patthy
| first4 = L
| doi = 10.1074/jbc.M803025200
| pmc = 3259755
}}
*{{Cite journal
| pmid = 12709070
| year = 2003
| author1 = Nagy
| first1 = A
| title = Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein
| journal = European Journal of Biochemistry / FEBS
| volume = 270
| issue = 9
| pages = 2101–7
| last2 = Trexler
| first2 = M
| last3 = Patthy
| first3 = L
| doi=10.1046/j.1432-1033.2003.03593.x
}}
*{{Cite journal
| pmid = 22395277
| year = 2012
| author1 = Dieli-Conwright
| first1 = C. M.
| title = Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women
| journal = Journal of Strength and Conditioning Research
| volume = 26
| issue = 5
| pages = 1374–82
| last2 = Spektor
| first2 = T. M.
| last3 = Rice
| first3 = J. C.
| last4 = Sattler
| first4 = F. R.
| last5 = Schroeder
| first5 = E. T.
| doi = 10.1519/JSC.0b013e318251083f
}}
*{{Cite journal
| pmid = 20026378
| year = 2010
| author1 = Saremi
| first1 = A
| title = Effects of oral creatine and resistance training on serum myostatin and GASP-1
| journal = Molecular and Cellular Endocrinology
| volume = 317
| issue = 1–2
| pages = 25–30
| last2 = Gharakhanloo
| first2 = R
| last3 = Sharghi
| first3 = S
| last4 = Gharaati
| first4 = M. R.
| last5 = Larijani
| first5 = B
| last6 = Omidfar
| first6 = K
| doi = 10.1016/j.mce.2009.12.019
}}
*{{Cite journal
| pmid = 11928817
| year = 2002
| author1 = Trexler
| first1 = M
| title = Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules
| journal = Biological Chemistry
| volume = 383
| issue = 1
| pages = 223–8
| last2 = Bányai
| first2 = L
| last3 = Patthy
| first3 = L
| doi = 10.1515/BC.2002.023
}}
 
{{refend}}
{{refend}}


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[[Category:Genes]]
[[Category:Genes]]
[[Category:Human proteins]]
[[Category:Human proteins]]


{{gene-17-stub}}
{{gene-17-stub}}

Latest revision as of 11:20, 20 January 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 is a protein that in humans is encoded by the WFIKKN2 gene.[1]

Function

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AY358142.1, AK127743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END##

See also

References

  1. ↑ "Entrez Gene: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2".

Further reading

  • Szláma G, Kondás K, Trexler M, Patthy L (December 2010). "WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity". The FEBS Journal. 277 (24): 5040–50. doi:10.1111/j.1742-4658.2010.07909.x. PMID 21054789.
  • Hill JJ, Qiu Y, Hewick RM, Wolfman NM (June 2003). "Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains". Molecular Endocrinology. 17 (6): 1144–54. doi:10.1210/me.2002-0366. PMID 12595574.
  • Kondás K, Szláma G, Trexler M, Patthy L (August 2008). "Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11". The Journal of Biological Chemistry. 283 (35): 23677–84. doi:10.1074/jbc.M803025200. PMC 3259755. PMID 18596030.
  • Nagy A, Trexler M, Patthy L (May 2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". European Journal of Biochemistry. 270 (9): 2101–7. doi:10.1046/j.1432-1033.2003.03593.x. PMID 12709070.
  • Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET (May 2012). "Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women". Journal of Strength and Conditioning Research. 26 (5): 1374–82. doi:10.1519/JSC.0b013e318251083f. PMID 22395277.
  • Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K (April 2010). "Effects of oral creatine and resistance training on serum myostatin and GASP-1". Molecular and Cellular Endocrinology. 317 (1–2): 25–30. doi:10.1016/j.mce.2009.12.019. PMID 20026378.
  • Trexler M, Bányai L, Patthy L (January 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biological Chemistry. 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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