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| '''17β-Hydroxysteroid dehydrogenase type 14''' also known as '''17β-HSD type 14''' or '''17βHSD14''' is an [[enzyme]] that in humans is encoded by the ''HSD17B14'' [[gene]].<ref name="Elsevier2016">{{cite book | title = Hormones, Brain and Behavior| chapter-url = https://books.google.com/books?id=NT8oCwAAQBAJ&pg=RA3-PA69 | date = 9 November 2016 | publisher = Elsevier Science | isbn = 978-0-12-803608-2 |pages = 69 | volume = 4: Clinical Important Effects of Hormones on Brain and Behavior | editor-first1 = Stafford | editor-last1 = Lightman | chapter = 4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition | first1 = Yuan-Shan | last1 = Zhu | first2 = Julianne L. | last2 = Imperato-McGinley | name-list-format = vanc }}</ref><ref name="Zanders2015">{{cite book | first1 = Edward D. | last1 = Zanders | name-list-format = vanc | title = Human Drug Targets: A Compendium for Pharmaceutical Discovery | url = https://books.google.com/books?id=airvCQAAQBAJ&pg=PA257 | date = 9 November 2015 | publisher = John Wiley & Sons | isbn = 978-1-118-84985-9 | pages = 257– }}</ref> | | '''17β-Hydroxysteroid dehydrogenase type 14''' also known as '''17β-HSD type 14''' or '''17βHSD14''' is an [[enzyme]] that in humans is encoded by the ''HSD17B14'' [[gene]].<ref name="Elsevier2016">{{cite book | title = Hormones, Brain and Behavior| chapter-url = https://books.google.com/books?id=NT8oCwAAQBAJ&pg=RA3-PA69 | date = 9 November 2016 | publisher = Elsevier Science | isbn = 978-0-12-803608-2 |pages = 69 | volume = 4: Clinical Important Effects of Hormones on Brain and Behavior | editor-first1 = Stafford | editor-last1 = Lightman | chapter = 4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition | first1 = Yuan-Shan | last1 = Zhu | first2 = Julianne L. | last2 = Imperato-McGinley | name-list-format = vanc }}</ref><ref name="Zanders2015">{{cite book | first1 = Edward D. | last1 = Zanders | name-list-format = vanc | title = Human Drug Targets: A Compendium for Pharmaceutical Discovery | url = https://books.google.com/books?id=airvCQAAQBAJ&pg=PA257 | date = 9 November 2015 | publisher = John Wiley & Sons | isbn = 978-1-118-84985-9 | pages = 257– }}</ref> |
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| 17βHSD14 catalyzes the stereospecific oxidation and reduction of the 17β carbon atom of [[androgen]]s and [[estrogen]]s using [[nicotinamide adenine dinucleotide phosphate|NAD(P)(H)]] as a cofactor. It is primarily expressed in glandular [[epithelial]] tissues of breast, ovary, and testis.<ref name="pmid22864907">{{cite journal | vauthors = Sivik T, Vikingsson S, Gréen H, Jansson A | title = Expression patterns of 17β-hydroxysteroid dehydrogenase 14 in human tissues | journal = Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme | volume = 44 | issue = 13 | pages = 949–56 | year = 2012 | pmid = 22864907 | doi = 10.1055/s-0032-1321815 }}</ref> | | 17βHSD14 catalyzes the stereospecific oxidation and reduction of the 17β carbon atom of [[androgen]]s and [[estrogen]]s using [[nicotinamide adenine dinucleotide phosphate|NAD(P)(H)]] as a cofactor. It is primarily expressed in glandular [[epithelial]] tissues of breast, ovary, and testis.<ref name="pmid22864907">{{cite journal | vauthors = Sivik T, Vikingsson S, Gréen H, Jansson A | title = Expression patterns of 17β-hydroxysteroid dehydrogenase 14 in human tissues | journal = Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme | volume = 44 | issue = 13 | pages = 949–56 | year = 2012 | pmid = 22864907 | doi = 10.1055/s-0032-1321815 | url = http://liu.diva-portal.org/smash/get/diva2:561150/FULLTEXT01 }}</ref> |
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| ==References== | | ==References== |
Latest revision as of 09:58, 9 September 2018
17β-Hydroxysteroid dehydrogenase type 14 also known as 17β-HSD type 14 or 17βHSD14 is an enzyme that in humans is encoded by the HSD17B14 gene.[1][2]
17βHSD14 catalyzes the stereospecific oxidation and reduction of the 17β carbon atom of androgens and estrogens using NAD(P)(H) as a cofactor. It is primarily expressed in glandular epithelial tissues of breast, ovary, and testis.[3]
References
