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{{Infobox_gene}}
{{Infobox_gene}}
'''Ligatin''' is a [[protein]] that in humans is encoded by the ''LGTN'' [[gene]].<ref name="pmid2482295">{{cite journal |vauthors=Jakoi ER, Brown AL, Ho YS, Snyderman R | title = Molecular cloning of the cDNA for ligatin | journal = J Cell Sci | volume = 93 | issue = 2| pages = 227–32 |date=Mar 1990 | pmid = 2482295 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LGTN ligatin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1939| accessdate = }}</ref>
'''Ligatin''', otherwise known as '''eIF2D''', is a [[protein]] that in humans is encoded by the ''LGTN'' [[gene]].<ref name="pmid2482295">{{cite journal | vauthors = Jakoi ER, Brown AL, Ho YS, Snyderman R | title = Molecular cloning of the cDNA for ligatin | journal = Journal of Cell Science | volume = 93 ( Pt 2) | issue = 2 | pages = 227–32 | date = June 1989 | pmid = 2482295 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LGTN ligatin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1939| accessdate = }}</ref> This protein is not a component of the heterotrimeric [[eIF2]] complex, but instead functions in different pathways of [[eukaryotic translation]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.<ref name="entrez" />
}}


==References==
This gene encodes a protein receptor that localizes phospho[[glycoprotein]]s within [[endosome]]s and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in [[neuroplasticity]] by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In [[hippocampal]] neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following [[glutamate receptor]] activation. This protein contains single [[PUA domain|PUA]] and [[SUI1 protein domain|SUI1]] domains and these domains may function in RNA binding and translation initiation, respectively.<ref name="entrez" />
 
== See also ==
*[[Eukaryotic translation]]
*[[Eukaryotic initiation factor]]
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Jakoi ER, Ross PE, Ping Ting-Beall H, Kaufman B, Vanaman TC | title = Ligatin: a peripheral membrane protein with covalently bound palmitic acid | journal = The Journal of Biological Chemistry | volume = 262 | issue = 3 | pages = 1300–4 | date = January 1987 | pmid = 3805022 | doi =  }}
| citations =
* {{cite journal | vauthors = Gaston SM, Marchase RB, Jakoi ER | title = Brain ligatin: a membrane lectin that binds acetylcholinesterase | journal = Journal of Cellular Biochemistry | volume = 18 | issue = 4 | pages = 447–59 | year = 1982 | pmid = 7085778 | doi = 10.1002/jcb.1982.240180406 }}
*{{cite journal   |vauthors=Jakoi ER, Ross PE, Ping Ting-Beall H, etal |title=Ligatin: a peripheral membrane protein with covalently bound palmitic acid |journal=J. Biol. Chem. |volume=262 |issue= 3 |pages= 1300–4 |year= 1987 |pmid= 3805022 |doi=  }}
* {{cite journal | vauthors = Marchase RB, Koro LA, Kelly CM, McClay DR | title = A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion | journal = Journal of Cellular Biochemistry | volume = 18 | issue = 4 | pages = 461–8 | year = 1982 | pmid = 7085779 | doi = 10.1002/jcb.1982.240180407 }}
*{{cite journal |vauthors=Gaston SM, Marchase RB, Jakoi ER |title=Brain ligatin: a membrane lectin that binds acetylcholinesterase |journal=J. Cell. Biochem. |volume=18 |issue= 4 |pages= 447–59 |year= 1982 |pmid= 7085778 |doi= 10.1002/jcb.1982.240180406 }}
* {{cite journal | vauthors = Jakoi ER, Kempe K, Gaston SM | title = Ligatin binds phosphohexose residues on acidic hydrolases | journal = Journal of Supramolecular Structure and Cellular Biochemistry | volume = 16 | issue = 2 | pages = 139–53 | year = 1982 | pmid = 7299841 | doi = 10.1002/jsscb.1981.380160205 }}
*{{cite journal |vauthors=Marchase RB, Koro LA, Kelly CM, McClay DR |title=A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion |journal=J. Cell. Biochem. |volume=18 |issue= 4 |pages= 461–8 |year= 1982 |pmid= 7085779 |doi= 10.1002/jcb.1982.240180407 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal |vauthors=Jakoi ER, Kempe K, Gaston SM |title=Ligatin binds phosphohexose residues on acidic hydrolases |journal=Journal of Supramolecular Structure and cellular biochemistry |volume=16 |issue= 2 |pages= 139–53 |year= 1982 |pmid= 7299841 |doi= 10.1002/jsscb.1981.380160205 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF | title = Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies | journal = Journal of Immunology | volume = 169 | issue = 2 | pages = 1102–9 | date = July 2002 | pmid = 12097419 | doi = 10.4049/jimmunol.169.2.1102 }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Wang Y, Han KJ, Pang XW, etal |title=Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies |journal=J. Immunol. |volume=169 |issue= 2 |pages= 1102–9 |year= 2002 |pmid= 12097419 |doi= 10.4049/jimmunol.169.2.1102}}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
}}
{{refend}}
{{refend}}


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{{PBB_Controls
| update_page = yes
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Latest revision as of 09:16, 3 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ligatin, otherwise known as eIF2D, is a protein that in humans is encoded by the LGTN gene.[1][2] This protein is not a component of the heterotrimeric eIF2 complex, but instead functions in different pathways of eukaryotic translation.

Function

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.[2]

See also

References

  1. ↑ Jakoi ER, Brown AL, Ho YS, Snyderman R (June 1989). "Molecular cloning of the cDNA for ligatin". Journal of Cell Science. 93 ( Pt 2) (2): 227–32. PMID 2482295.
  2. ↑ 2.0 2.1 "Entrez Gene: LGTN ligatin".

Further reading

  • Jakoi ER, Ross PE, Ping Ting-Beall H, Kaufman B, Vanaman TC (January 1987). "Ligatin: a peripheral membrane protein with covalently bound palmitic acid". The Journal of Biological Chemistry. 262 (3): 1300–4. PMID 3805022.
  • Gaston SM, Marchase RB, Jakoi ER (1982). "Brain ligatin: a membrane lectin that binds acetylcholinesterase". Journal of Cellular Biochemistry. 18 (4): 447–59. doi:10.1002/jcb.1982.240180406. PMID 7085778.
  • Marchase RB, Koro LA, Kelly CM, McClay DR (1982). "A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion". Journal of Cellular Biochemistry. 18 (4): 461–8. doi:10.1002/jcb.1982.240180407. PMID 7085779.
  • Jakoi ER, Kempe K, Gaston SM (1982). "Ligatin binds phosphohexose residues on acidic hydrolases". Journal of Supramolecular Structure and Cellular Biochemistry. 16 (2): 139–53. doi:10.1002/jsscb.1981.380160205. PMID 7299841.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF (July 2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". Journal of Immunology. 169 (2): 1102–9. doi:10.4049/jimmunol.169.2.1102. PMID 12097419.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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