Aldehyde dehydrogenase 9 family, member A1: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''4-trimethylaminobutyraldehyde dehydrogenase''' is an [[enzyme]] that in humans is encoded by the ''ALDH9A1'' [[gene]].<ref name="pmid8112751">{{cite journal | vauthors = McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R | title = Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde | journal = Hum Genet | volume = 93 | issue = 2 | pages = 211–2 |date=Mar 1994 | pmid = 8112751 | pmc =  | doi = 10.1007/bf00210615}}</ref><ref name="pmid8786138">{{cite journal | vauthors = Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A | title = Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression | journal = Genomics | volume = 34 | issue = 3 | pages = 376–80 |date=Sep 1996 | pmid = 8786138 | pmc =  | doi = 10.1006/geno.1996.0300 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=223| accessdate = }}</ref>
'''4-trimethylaminobutyraldehyde dehydrogenase''' is an [[enzyme]] that in humans is encoded by the ''ALDH9A1'' [[gene]].<ref name="pmid8112751">{{cite journal | vauthors = McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R | title = Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde | journal = Human Genetics | volume = 93 | issue = 2 | pages = 211–2 | date = February 1994 | pmid = 8112751 | pmc =  | doi = 10.1007/bf00210615 }}</ref><ref name="pmid8786138">{{cite journal | vauthors = Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A | title = Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression | journal = Genomics | volume = 34 | issue = 3 | pages = 376–80 | date = June 1996 | pmid = 8786138 | pmc =  | doi = 10.1006/geno.1996.0300 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=223| access-date = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.<ref name="entrez"/>
}}


==References==
This protein belongs to the [[aldehyde dehydrogenase]] family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to [[gamma-aminobutyric acid]] (GABA). This isozyme is a [[tetramer]] of identical 54-kD subunits.<ref name="entrez"/>
 
== References ==
{{reflist}}
{{reflist}}


==External links==
== External links ==
* {{UCSC gene info|ALDH9A1}}
* {{UCSC gene info|ALDH9A1}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kurys G, Ambroziak W, Pietruszko R | title = Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde | journal = The Journal of Biological Chemistry | volume = 264 | issue = 8 | pages = 4715–21 | date = March 1989 | pmid = 2925663 | doi =  }}
| citations =
* {{cite journal | vauthors = Kurys G, Shah PC, Kikonygo A, Reed D, Ambroziak W, Pietruszko R | title = Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde | journal = European Journal of Biochemistry | volume = 218 | issue = 2 | pages = 311–20 | date = December 1993 | pmid = 8269919 | doi = 10.1111/j.1432-1033.1993.tb18379.x }}
*{{cite journal | vauthors=Kurys G, Ambroziak W, Pietruszko R |title=Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde. |journal=J. Biol. Chem. |volume=264 |issue= 8 |pages= 4715–21 |year= 1989 |pmid= 2925663 |doi=  }}
* {{cite journal | vauthors = Kikonyogo A, Pietruszko R | title = Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution | journal = The Biochemical Journal | volume = 316 ( Pt 1) | issue = 1 | pages = 317–24 | date = May 1996 | pmid = 8645224 | pmc = 1217341 | doi = }}
*{{cite journal | vauthors=Kurys G, Shah PC, Kikonygo A |title=Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde. |journal=Eur. J. Biochem. |volume=218 |issue= 2 |pages= 311–20 |year= 1994 |pmid= 8269919 |doi= 10.1111/j.1432-1033.1993.tb18379.x|display-authors=etal}}
* {{cite journal | vauthors = Izaguirre G, Kikonyogo A, Pietruszko R | title = Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution | journal = Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology | volume = 118 | issue = 1 | pages = 59–64 | date = September 1997 | pmid = 9417993 | doi = 10.1016/s0305-0491(97)00022-9 }}
*{{cite journal | vauthors=Kikonyogo A, Pietruszko R |title=Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution. |journal=Biochem. J. |volume=316 |issue= 1|pages= 317–24 |year= 1996 |pmid= 8645224 |doi= |pmc=1217341}}
* {{cite journal | vauthors = Vaz FM, Fouchier SW, Ofman R, Sommer M, Wanders RJ | title = Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis | journal = The Journal of Biological Chemistry | volume = 275 | issue = 10 | pages = 7390–4 | date = March 2000 | pmid = 10702312 | doi = 10.1074/jbc.275.10.7390 }}
*{{cite journal | vauthors=Izaguirre G, Kikonyogo A, Pietruszko R |title=Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution. |journal=Comp. Biochem. Physiol. B, Biochem. Mol. Biol. |volume=118 |issue= 1 |pages= 59–64 |year= 1998 |pmid= 9417993 |doi= 10.1016/s0305-0491(97)00022-9}}
* {{cite journal | vauthors = Izaguirre G, Pietruszko R, Cho S, MacKerell A | title = Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs | journal = Journal of Biomolecular Structure & Dynamics | volume = 19 | issue = 3 | pages = 429–47 | date = December 2001 | pmid = 11790142 | doi = 10.1080/07391102.2001.10506752 }}
*{{cite journal | vauthors=Vaz FM, Fouchier SW, Ofman R |title=Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7390–4 |year= 2000 |pmid= 10702312 |doi= 10.1074/jbc.275.10.7390|display-authors=etal}}
*{{cite journal | vauthors=Izaguirre G, Pietruszko R, Cho S, MacKerell A |title=Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs. |journal=J. Biomol. Struct. Dyn. |volume=19 |issue= 3 |pages= 429–47 |year= 2002 |pmid= 11790142 |doi= 10.1080/07391102.2001.10506752}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|display-authors=etal}}
*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
}}
{{refend}}
{{refend}}


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{{Aldehyde dehydrogenases}}
{{Aldehyde dehydrogenases}}


{{gene-1-stub}}
{{gene-1-stub}}

Latest revision as of 08:13, 5 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.[1][2][3]

Function

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.[3]

References

  1. ↑ McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (February 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Human Genetics. 93 (2): 211–2. doi:10.1007/bf00210615. PMID 8112751.
  2. ↑ Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (June 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression". Genomics. 34 (3): 376–80. doi:10.1006/geno.1996.0300. PMID 8786138.
  3. ↑ 3.0 3.1 "Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1".

External links

Further reading

  • Kurys G, Ambroziak W, Pietruszko R (March 1989). "Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde". The Journal of Biological Chemistry. 264 (8): 4715–21. PMID 2925663.
  • Kurys G, Shah PC, Kikonygo A, Reed D, Ambroziak W, Pietruszko R (December 1993). "Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde". European Journal of Biochemistry. 218 (2): 311–20. doi:10.1111/j.1432-1033.1993.tb18379.x. PMID 8269919.
  • Kikonyogo A, Pietruszko R (May 1996). "Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution". The Biochemical Journal. 316 ( Pt 1) (1): 317–24. PMC 1217341. PMID 8645224.
  • Izaguirre G, Kikonyogo A, Pietruszko R (September 1997). "Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 118 (1): 59–64. doi:10.1016/s0305-0491(97)00022-9. PMID 9417993.
  • Vaz FM, Fouchier SW, Ofman R, Sommer M, Wanders RJ (March 2000). "Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis". The Journal of Biological Chemistry. 275 (10): 7390–4. doi:10.1074/jbc.275.10.7390. PMID 10702312.
  • Izaguirre G, Pietruszko R, Cho S, MacKerell A (December 2001). "Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs". Journal of Biomolecular Structure & Dynamics. 19 (3): 429–47. doi:10.1080/07391102.2001.10506752. PMID 11790142.


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