RBM8A: Difference between revisions

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==Interactions==
==Interactions==
RBM8A has been shown to [[Protein-protein interaction|interact]] with [[IPO13]],<ref name=pmid11447110>{{cite journal |last=Mingot |first=J M |authorlink= |author2=Kostka S |author3=Kraft R |author4=Hartmann E |author5=Görlich D  |date=July 2001 |title=Importin 13: a novel mediator of nuclear import and export |journal=EMBO J. |volume=20 |issue=14 |pages=3685–94 |publisher= |location = England| issn = 0261-4189| pmid = 11447110 |doi = 10.1093/emboj/20.14.3685 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | pmc = 125545 }}</ref> [[MAGOH]]<ref name=pmid10662555>{{cite journal |last=Zhao |first=X F |authorlink= |author2=Nowak N J |author3=Shows T B |author4=Aplan P D  |date=January 2000 |title=MAGOH interacts with a novel RNA-binding protein |journal=Genomics |volume=63 |issue=1 |pages=145–8 |publisher= |location = UNITED STATES| issn = 0888-7543| pmid = 10662555 |doi = 10.1006/geno.1999.6064 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11707413>{{cite journal |last=Kataoka |first=N |authorlink= |author2=Diem M D |author3=Kim V N |author4=Yong J |author5=Dreyfuss G  |date=November 2001 |title=Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon–exon junction complex |journal=EMBO J. |volume=20 |issue=22 |pages=6424–33 |publisher= |location = England| issn = 0261-4189| pmid = 11707413 |doi = 10.1093/emboj/20.22.6424 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | pmc = 125744 }}</ref> and [[UPF3A]].<ref name=pmid11546873>{{cite journal |last=Kim |first=V N |authorlink= |author2=Kataoka N |author3=Dreyfuss G  |date=September 2001 |title=Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex |journal=[[Science (journal)|Science]] |volume=293 |issue=5536 |pages=1832–6 |publisher= |location = United States| issn = 0036-8075| pmid = 11546873 |doi = 10.1126/science.1062829 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
RBM8A has been shown to [[Protein-protein interaction|interact]] with [[IPO13]],<ref name=pmid11447110>{{cite journal |last=Mingot |first=J M |authorlink= |author2=Kostka S |author3=Kraft R |author4=Hartmann E |author5=Görlich D  |date=July 2001 |title=Importin 13: a novel mediator of nuclear import and export |journal=EMBO J. |volume=20 |issue=14 |pages=3685–94 |publisher= |location = England| issn = 0261-4189| pmid = 11447110 |doi = 10.1093/emboj/20.14.3685 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | pmc = 125545 }}</ref> [[MAGOH]]<ref name=pmid10662555>{{cite journal |last=Zhao |first=X F |authorlink= |author2=Nowak N J |author3=Shows T B |author4=Aplan P D  |date=January 2000 |title=MAGOH interacts with a novel RNA-binding protein |journal=Genomics |volume=63 |issue=1 |pages=145–8 |publisher= |location = UNITED STATES| issn = 0888-7543| pmid = 10662555 |doi = 10.1006/geno.1999.6064 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11707413>{{cite journal |last=Kataoka |first=N |authorlink= |author2=Diem M D |author3=Kim V N |author4=Yong J |author5=Dreyfuss G  |date=November 2001 |title=Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon–exon junction complex |journal=EMBO J. |volume=20 |issue=22 |pages=6424–33 |publisher= |location = England| issn = 0261-4189| pmid = 11707413 |doi = 10.1093/emboj/20.22.6424 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | pmc = 125744 }}</ref> and [[UPF3A]].<ref name=pmid11546873>{{cite journal |last=Kim |first=V N |authorlink= |author2=Kataoka N |author3=Dreyfuss G  |date=September 2001 |title=Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex |journal=[[Science (journal)|Science]] |volume=293 |issue=5536 |pages=1832–6 |publisher= |location = United States| issn = 0036-8075| pmid = 11546873 |doi = 10.1126/science.1062829 | bibcode =2001Sci...293.1832K | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==Related gene problems==
==Related gene problems==
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*{{cite journal  |vauthors=Le Hir H, Izaurralde E, Maquat LE, Moore MJ |title=The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions |journal=EMBO J. |volume=19 |issue= 24 |pages= 6860–9 |year= 2001 |pmid= 11118221 |doi= 10.1093/emboj/19.24.6860  | pmc=305905 }}
*{{cite journal  |vauthors=Le Hir H, Izaurralde E, Maquat LE, Moore MJ |title=The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions |journal=EMBO J. |volume=19 |issue= 24 |pages= 6860–9 |year= 2001 |pmid= 11118221 |doi= 10.1093/emboj/19.24.6860  | pmc=305905 }}
*{{cite journal  |vauthors=Mingot JM, Kostka S, Kraft R, etal |title=Importin 13: a novel mediator of nuclear import and export |journal=EMBO J. |volume=20 |issue= 14 |pages= 3685–94 |year= 2001 |pmid= 11447110 |doi= 10.1093/emboj/20.14.3685  | pmc=125545 }}
*{{cite journal  |vauthors=Mingot JM, Kostka S, Kraft R, etal |title=Importin 13: a novel mediator of nuclear import and export |journal=EMBO J. |volume=20 |issue= 14 |pages= 3685–94 |year= 2001 |pmid= 11447110 |doi= 10.1093/emboj/20.14.3685  | pmc=125545 }}
*{{cite journal  |vauthors=Kim VN, Kataoka N, Dreyfuss G |title=Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex |journal=Science |volume=293 |issue= 5536 |pages= 1832–6 |year= 2001 |pmid= 11546873 |doi= 10.1126/science.1062829 }}
*{{cite journal  |vauthors=Kim VN, Kataoka N, Dreyfuss G |title=Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex |journal=Science |volume=293 |issue= 5536 |pages= 1832–6 |year= 2001 |pmid= 11546873 |doi= 10.1126/science.1062829 |bibcode=2001Sci...293.1832K }}
*{{cite journal  |vauthors=Lykke-Andersen J, Shu MD, Steitz JA |title=Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1 |journal=Science |volume=293 |issue= 5536 |pages= 1836–9 |year= 2001 |pmid= 11546874 |doi= 10.1126/science.1062786 }}
*{{cite journal  |vauthors=Lykke-Andersen J, Shu MD, Steitz JA |title=Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1 |journal=Science |volume=293 |issue= 5536 |pages= 1836–9 |year= 2001 |pmid= 11546874 |doi= 10.1126/science.1062786 |bibcode=2001Sci...293.1836L }}
*{{cite journal  |vauthors=Hachet O, Ephrussi A |title=Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport |journal=Curr. Biol. |volume=11 |issue= 21 |pages= 1666–74 |year= 2002 |pmid= 11696323 |doi=10.1016/S0960-9822(01)00508-5  }}
*{{cite journal  |vauthors=Hachet O, Ephrussi A |title=Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport |journal=Curr. Biol. |volume=11 |issue= 21 |pages= 1666–74 |year= 2002 |pmid= 11696323 |doi=10.1016/S0960-9822(01)00508-5  }}
*{{cite journal  |vauthors=Faurholm B, Millar RP, Katz AA |title=The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci |journal=Genomics |volume=78 |issue= 1–2 |pages= 15–8 |year= 2002 |pmid= 11707068 |doi= 10.1006/geno.2001.6650 }}
*{{cite journal  |vauthors=Faurholm B, Millar RP, Katz AA |title=The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci |journal=Genomics |volume=78 |issue= 1–2 |pages= 15–8 |year= 2002 |pmid= 11707068 |doi= 10.1006/geno.2001.6650 }}
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*{{cite journal  |vauthors=Okubo K, Mitani H, Naruse K, etal |title=Conserved physical linkage of GnRH-R and RBM8 in the medaka and human genomes |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 327–31 |year= 2002 |pmid= 12054603 |doi= 10.1016/S0006-291X(02)00161-4 }}
*{{cite journal  |vauthors=Okubo K, Mitani H, Naruse K, etal |title=Conserved physical linkage of GnRH-R and RBM8 in the medaka and human genomes |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 327–31 |year= 2002 |pmid= 12054603 |doi= 10.1016/S0006-291X(02)00161-4 }}
*{{cite journal  |vauthors=Lejeune F, Ishigaki Y, Li X, Maquat LE |title=The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling |journal=EMBO J. |volume=21 |issue= 13 |pages= 3536–45 |year= 2002 |pmid= 12093754 |doi= 10.1093/emboj/cdf345  | pmc=126094 }}
*{{cite journal  |vauthors=Lejeune F, Ishigaki Y, Li X, Maquat LE |title=The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling |journal=EMBO J. |volume=21 |issue= 13 |pages= 3536–45 |year= 2002 |pmid= 12093754 |doi= 10.1093/emboj/cdf345  | pmc=126094 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Gehring NH, Neu-Yilik G, Schell T, etal |title=Y14 and hUpf3b form an NMD-activating complex |journal=Mol. Cell |volume=11 |issue= 4 |pages= 939–49 |year= 2003 |pmid= 12718880 |doi=10.1016/S1097-2765(03)00142-4  }}
*{{cite journal  |vauthors=Gehring NH, Neu-Yilik G, Schell T, etal |title=Y14 and hUpf3b form an NMD-activating complex |journal=Mol. Cell |volume=11 |issue= 4 |pages= 939–49 |year= 2003 |pmid= 12718880 |doi=10.1016/S1097-2765(03)00142-4  }}
*{{cite journal  |vauthors=Fribourg S, Gatfield D, Izaurralde E, Conti E |title=A novel mode of RBD-protein recognition in the Y14-Mago complex |journal=Nat. Struct. Biol. |volume=10 |issue= 6 |pages= 433–9 |year= 2003 |pmid= 12730685 |doi= 10.1038/nsb926 }}
*{{cite journal  |vauthors=Fribourg S, Gatfield D, Izaurralde E, Conti E |title=A novel mode of RBD-protein recognition in the Y14-Mago complex |journal=Nat. Struct. Biol. |volume=10 |issue= 6 |pages= 433–9 |year= 2003 |pmid= 12730685 |doi= 10.1038/nsb926 }}

Latest revision as of 01:37, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RNA-binding protein 8A is a protein that in humans is encoded by the RBM8A gene.[1][2]

This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.[3]

Interactions

RBM8A has been shown to interact with IPO13,[4] MAGOH[5][6] and UPF3A.[7]

Related gene problems

References

  1. ↑ Conklin DC, Rixon MW, Kuestner RE, Maurer MF, Whitmore TE, Millar RP (October 2000). "Cloning and gene expression of a novel human ribonucleoprotein". Biochim Biophys Acta. 1492 (2–3): 465–9. doi:10.1016/s0167-4781(00)00090-7. PMID 11004516.
  2. ↑ Salicioni AM, Xi M, Vanderveer LA, Balsara B, Testa JR, Dunbrack RL Jr, Godwin AK (October 2000). "Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor". Genomics. 69 (1): 54–62. doi:10.1006/geno.2000.6315. PMID 11013075.
  3. ↑ "Entrez Gene: RBM8A RNA binding motif protein 8A".
  4. ↑ Mingot, J M; Kostka S; Kraft R; Hartmann E; Görlich D (July 2001). "Importin 13: a novel mediator of nuclear import and export". EMBO J. England. 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. ISSN 0261-4189. PMC 125545. PMID 11447110.
  5. ↑ Zhao, X F; Nowak N J; Shows T B; Aplan P D (January 2000). "MAGOH interacts with a novel RNA-binding protein". Genomics. UNITED STATES. 63 (1): 145–8. doi:10.1006/geno.1999.6064. ISSN 0888-7543. PMID 10662555.
  6. ↑ Kataoka, N; Diem M D; Kim V N; Yong J; Dreyfuss G (November 2001). "Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon–exon junction complex". EMBO J. England. 20 (22): 6424–33. doi:10.1093/emboj/20.22.6424. ISSN 0261-4189. PMC 125744. PMID 11707413.
  7. ↑ Kim, V N; Kataoka N; Dreyfuss G (September 2001). "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex". Science. United States. 293 (5536): 1832–6. Bibcode:2001Sci...293.1832K. doi:10.1126/science.1062829. ISSN 0036-8075. PMID 11546873.
  8. ↑ Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading



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