PGAP1: Difference between revisions

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==Function==
==Function==


The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause of mental retardation, autosomal recessive 42.
The protein encoded by this gene functions early in the [[glycosylphosphatidylinositol]] (GPI) biosynthetic pathway, catalyzing the [[inositol]] deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the [[endoplasmic reticulum]] to the [[Golg]]i. Defects in this gene are a cause of [[mental retardation]], autosomal recessive 42.


== References ==
== References ==

Latest revision as of 15:59, 14 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Post-GPI attachment to proteins 1 is a protein that in humans is encoded by the PGAP1 gene.[1]

Function

The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause of mental retardation, autosomal recessive 42.

References

  1. ↑ "Entrez Gene: Post-GPI attachment to proteins 1". Retrieved 2016-04-04.

Further reading

  • Tanaka S, Maeda Y, Tashima Y, Kinoshita T (2004). "Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p". J. Biol. Chem. 279 (14): 14256–63. doi:10.1074/jbc.M313755200. PMID 14734546.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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