FXR1: Difference between revisions

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==Interactions==
==Interactions==
FXR1 has been shown to [[Protein-protein interaction|interact]] with [[FXR2]],<ref name=pmid8668200>{{cite journal |last=Siomi |first=M C |authorlink= |author2=Zhang Y |author3=Siomi H |author4=Dreyfuss G  |date=July 1996  |title=Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them |journal=Mol. Cell. Biol. |volume=16 |issue=7 |pages=3825–32 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 8668200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=231379 | doi=10.1128/mcb.16.7.3825}}</ref><ref name=pmid7489725>{{cite journal |last=Zhang |first=Y |authorlink= |author2=O'Connor J P |author3=Siomi M C |author4=Srinivasan S |author5=Dutra A |author6=Nussbaum R L |author7=Dreyfuss G  |date=November 1995  |title=The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2 |journal=EMBO J. |volume=14 |issue=21 |pages=5358–66 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 7489725 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=394645 }}</ref> [[FMR1]] <ref name=pmid8668200/><ref name=pmid7489725/> and [[CYFIP2]].<ref name = pmid11438699>{{cite journal | vauthors = Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL | title = A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 15 | pages = 8844–9 | date = Jul 2001 | pmid = 11438699 | pmc = 37523 | doi = 10.1073/pnas.151231598 }}</ref>
FXR1 has been shown to [[Protein-protein interaction|interact]] with [[FXR2]],<ref name=pmid8668200>{{cite journal |last=Siomi |first=M C |authorlink= |author2=Zhang Y |author3=Siomi H |author4=Dreyfuss G  |date=July 1996  |title=Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them |journal=Mol. Cell. Biol. |volume=16 |issue=7 |pages=3825–32 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 8668200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=231379 | doi=10.1128/mcb.16.7.3825}}</ref><ref name=pmid7489725>{{cite journal |last=Zhang |first=Y |authorlink= |author2=O'Connor J P |author3=Siomi M C |author4=Srinivasan S |author5=Dutra A |author6=Nussbaum R L |author7=Dreyfuss G  |date=November 1995  |title=The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2 |journal=EMBO J. |volume=14 |issue=21 |pages=5358–66 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 7489725 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=394645 }}</ref> [[FMR1]] <ref name=pmid8668200/><ref name=pmid7489725/> and [[CYFIP2]].<ref name = pmid11438699>{{cite journal | vauthors = Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL | title = A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 15 | pages = 8844–9 | date = Jul 2001 | pmid = 11438699 | pmc = 37523 | doi = 10.1073/pnas.151231598 | bibcode = 2001PNAS...98.8844S }}</ref>


==References==
==References==
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*{{cite journal  |vauthors=Tamanini F, Kirkpatrick LL, Schonkeren J |title=The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins |journal=Hum. Mol. Genet. |volume=9 |issue= 10 |pages= 1487–93 |year= 2000 |pmid= 10888599 |doi=10.1093/hmg/9.10.1487  |display-authors=etal}}
*{{cite journal  |vauthors=Tamanini F, Kirkpatrick LL, Schonkeren J |title=The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins |journal=Hum. Mol. Genet. |volume=9 |issue= 10 |pages= 1487–93 |year= 2000 |pmid= 10888599 |doi=10.1093/hmg/9.10.1487  |display-authors=etal}}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal  |vauthors=Schenck A, Bardoni B, Moro A |title=A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 15 |pages= 8844–9 |year= 2001 |pmid= 11438699 |doi= 10.1073/pnas.151231598  | pmc=37523 |display-authors=etal}}
*{{cite journal  |vauthors=Schenck A, Bardoni B, Moro A |title=A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 15 |pages= 8844–9 |year= 2001 |pmid= 11438699 |doi= 10.1073/pnas.151231598  | pmc=37523 |display-authors=etal|bibcode=2001PNAS...98.8844S }}
*{{cite journal  |vauthors=Kirkpatrick LL, McIlwain KA, Nelson DL |title=Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2 |journal=Genomics |volume=78 |issue= 3 |pages= 169–77 |year= 2002 |pmid= 11735223 |doi= 10.1006/geno.2001.6667 }}
*{{cite journal  |vauthors=Kirkpatrick LL, McIlwain KA, Nelson DL |title=Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2 |journal=Genomics |volume=78 |issue= 3 |pages= 169–77 |year= 2002 |pmid= 11735223 |doi= 10.1006/geno.2001.6667 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Imabayashi H, Mori T, Gojo S |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35–50 |year= 2003 |pmid= 12878157 |doi=10.1016/S0014-4827(03)00130-7  |display-authors=etal}}
*{{cite journal  |vauthors=Imabayashi H, Mori T, Gojo S |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35–50 |year= 2003 |pmid= 12878157 |doi=10.1016/S0014-4827(03)00130-7  |display-authors=etal}}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}

Latest revision as of 14:08, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fragile X mental retardation syndrome-related protein 1 is a protein that in humans is encoded by the FXR1 gene.[1][2][3]

The protein encoded by this gene is an RNA binding protein that interacts with the functionally similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

FXR1 has been shown to interact with FXR2,[4][5] FMR1 [4][5] and CYFIP2.[6]

References

  1. ↑ Siomi MC, Siomi H, Sauer WH, Srinivasan S, Nussbaum RL, Dreyfuss G (July 1995). "FXR1, an autosomal homolog of the fragile X mental retardation gene". EMBO J. 14 (11): 2401–8. PMC 398353. PMID 7781595.
  2. ↑ Bolivar J, Guelman S, Iglesias C, Ortiz M, Valdivia MM (August 1998). "The fragile-X-related gene FXR1 is a human autoantigen processed during apoptosis". J Biol Chem. 273 (27): 17122–7. doi:10.1074/jbc.273.27.17122. PMID 9642279.
  3. ↑ 3.0 3.1 "Entrez Gene: FXR1 fragile X mental retardation, autosomal homolog 1".
  4. ↑ 4.0 4.1 Siomi, M C; Zhang Y; Siomi H; Dreyfuss G (July 1996). "Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them". Mol. Cell. Biol. UNITED STATES. 16 (7): 3825–32. doi:10.1128/mcb.16.7.3825. ISSN 0270-7306. PMC 231379. PMID 8668200.
  5. ↑ 5.0 5.1 Zhang, Y; O'Connor J P; Siomi M C; Srinivasan S; Dutra A; Nussbaum R L; Dreyfuss G (November 1995). "The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2". EMBO J. ENGLAND. 14 (21): 5358–66. ISSN 0261-4189. PMC 394645. PMID 7489725.
  6. ↑ Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL (Jul 2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8844–9. Bibcode:2001PNAS...98.8844S. doi:10.1073/pnas.151231598. PMC 37523. PMID 11438699.

Further reading



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