MAP4: Difference between revisions

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| summary_text = The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein ([[MAP2]]) and microtubule-associated protein tau ([[MAPT|MAPT/TAU]]). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 ([[Cdk1|CDC2]]) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported.<ref name="entrez">{{cite web | title = Entrez Gene: MAP4 microtubule-associated protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4134| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein ([[MAP2]]) and microtubule-associated protein tau ([[MAPT|MAPT/TAU]]). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 ([[Cdk1|CDC2]]) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported.<ref name="entrez">{{cite web | title = Entrez Gene: MAP4 microtubule-associated protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4134| accessdate = }}</ref>
uMAP4, the ubiquitous isoform of MAP4, functions in the architecture and positioning of the mitotic spindle in human cells.<ref>{{cite journal|last1=Samora|first1=Catarina P.|last2=Mogessie|first2=Binyam|last3=Conway|first3=Leslie|last4=Ross|first4=Jennifer L.|last5=Straube|first5=Anne|last6=McAinsh|first6=Andrew D.|title=MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis|journal=Nature Cell Biology|date=7 August 2011|volume=13|issue=9|pages=1040–1050|doi=10.1038/ncb2297|pmid=21822276}}</ref> oMAP4 is predominantly expressed in brain and muscle and has been shown to organise microtubules into antiparallel bundles.<ref name="oMAP4">{{cite journal|last1=Mogessie|first1=Binyam|last2=Roth|first2=Daniel|last3=Rahil|first3=Zainab|last4=Straube|first4=Anne|title=A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation|journal=eLife|date=21 April 2015|volume=4|doi=10.7554/eLife.05697|pmid=25898002|pmc=4423121}}</ref> mMAP4 is a muscle-specific isoform.<ref name=oMAP4 /><ref>{{cite journal|last1=Casey|first1=LM|last2=Lyon|first2=HD|last3=Olmsted|first3=JB|title=Muscle-specific microtubule-associated protein 4 is expressed early in myogenesis and is not sufficient to induce microtubule reorganization.|journal=Cell motility and the cytoskeleton|date=April 2003|volume=54|issue=4|pages=317–36|pmid=12601693|doi=10.1002/cm.10105}}</ref>
uMAP4, the ubiquitous isoform of MAP4, functions in the architecture and positioning of the mitotic spindle in human cells.<ref>{{cite journal|last1=Samora|first1=Catarina P.|last2=Mogessie|first2=Binyam|last3=Conway|first3=Leslie|last4=Ross|first4=Jennifer L.|last5=Straube|first5=Anne|last6=McAinsh|first6=Andrew D.|title=MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis|journal=Nature Cell Biology|date=7 August 2011|volume=13|issue=9|pages=1040–1050|doi=10.1038/ncb2297|pmid=21822276}}</ref> oMAP4 is predominantly expressed in brain and muscle and has been shown to organise microtubules into antiparallel bundles.<ref name="oMAP4">{{cite journal|last1=Mogessie|first1=Binyam|last2=Roth|first2=Daniel|last3=Rahil|first3=Zainab|last4=Straube|first4=Anne|title=A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation|journal=eLife|date=21 April 2015|volume=4|doi=10.7554/eLife.05697|pmid=25898002|pmc=4423121}}</ref> mMAP4 is a muscle-specific isoform.<ref name=oMAP4 /><ref>{{cite journal|last1=Casey|first1=LM|last2=Lyon|first2=HD|last3=Olmsted|first3=JB|title=Muscle-specific microtubule-associated protein 4 is expressed early in myogenesis and is not sufficient to induce microtubule reorganization.|journal=Cell Motility and the Cytoskeleton|date=April 2003|volume=54|issue=4|pages=317–36|pmid=12601693|doi=10.1002/cm.10105}}</ref>
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Latest revision as of 14:50, 16 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene.[1]

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported.[2] uMAP4, the ubiquitous isoform of MAP4, functions in the architecture and positioning of the mitotic spindle in human cells.[3] oMAP4 is predominantly expressed in brain and muscle and has been shown to organise microtubules into antiparallel bundles.[4] mMAP4 is a muscle-specific isoform.[4][5]

References

  1. ↑ Chapin SJ, Bulinski JC (Jul 1991). "Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau". J Cell Sci. 98. ( Pt 1): 27–36. PMID 1905296.
  2. ↑ "Entrez Gene: MAP4 microtubule-associated protein 4".
  3. ↑ Samora, Catarina P.; Mogessie, Binyam; Conway, Leslie; Ross, Jennifer L.; Straube, Anne; McAinsh, Andrew D. (7 August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology. 13 (9): 1040–1050. doi:10.1038/ncb2297. PMID 21822276.
  4. ↑ 4.0 4.1 Mogessie, Binyam; Roth, Daniel; Rahil, Zainab; Straube, Anne (21 April 2015). "A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation". eLife. 4. doi:10.7554/eLife.05697. PMC 4423121. PMID 25898002.
  5. ↑ Casey, LM; Lyon, HD; Olmsted, JB (April 2003). "Muscle-specific microtubule-associated protein 4 is expressed early in myogenesis and is not sufficient to induce microtubule reorganization". Cell Motility and the Cytoskeleton. 54 (4): 317–36. doi:10.1002/cm.10105. PMID 12601693.

Further reading



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