SRPRB: Difference between revisions
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'''Signal recognition particle receptor subunit beta''' is a [[protein]] that in humans is encoded by the ''SRPRB'' [[gene]].<ref name="pmid7844142">{{cite journal | vauthors = Miller JD, Tajima S, Lauffer L, Walter P | title = The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane | journal = J Cell Biol | volume = 128 | issue = 3 | pages = 273–82 |date=Mar 1995 | pmid = 7844142 | pmc = 2120348 | doi =10.1083/jcb.128.3.273 }}</ref><ref name="pmid10859309">{{cite journal | vauthors = Legate KR, Falcone D, Andrews DW | title = Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit | journal = J Biol Chem | volume = 275 | issue = 35 | pages = 27439–46 |date=Oct 2000 | pmid = 10859309 | pmc = | doi = 10.1074/jbc.M003215200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SRPRB signal recognition particle receptor, B subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=58477| accessdate = }}</ref> | '''Signal recognition particle receptor subunit beta''' is a [[protein]] that in humans is encoded by the ''SRPRB'' [[gene]].<ref name="pmid7844142">{{cite journal | vauthors = Miller JD, Tajima S, Lauffer L, Walter P | title = The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane | journal = J Cell Biol | volume = 128 | issue = 3 | pages = 273–82 |date=Mar 1995 | pmid = 7844142 | pmc = 2120348 | doi =10.1083/jcb.128.3.273 }}</ref><ref name="pmid10859309">{{cite journal | vauthors = Legate KR, Falcone D, Andrews DW | title = Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit | journal = J Biol Chem | volume = 275 | issue = 35 | pages = 27439–46 |date=Oct 2000 | pmid = 10859309 | pmc = | doi = 10.1074/jbc.M003215200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SRPRB signal recognition particle receptor, B subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=58477| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
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| summary_text = The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.<ref name="entrez" /> | | summary_text = The protein encoded by this gene has similarity to mouse protein which is a subunit of the [[signal recognition particle receptor]] (SR). This subunit is a [[transmembrane]] GTPase belonging to the [[GTPase]] superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the [[ER membrane]]. SR is required for the cotranslational targeting of both [[secretory protein|secretory]] and [[membrane proteins]] to the ER membrane.<ref name="entrez" /> | ||
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Latest revision as of 21:30, 20 February 2018
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Signal recognition particle receptor subunit beta is a protein that in humans is encoded by the SRPRB gene.[1][2][3]
The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.[3]
References
- ↑ Miller JD, Tajima S, Lauffer L, Walter P (Mar 1995). "The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane". J Cell Biol. 128 (3): 273–82. doi:10.1083/jcb.128.3.273. PMC 2120348. PMID 7844142.
- ↑ Legate KR, Falcone D, Andrews DW (Oct 2000). "Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit". J Biol Chem. 275 (35): 27439–46. doi:10.1074/jbc.M003215200. PMID 10859309.
- ↑ 3.0 3.1 "Entrez Gene: SRPRB signal recognition particle receptor, B subunit".
Further reading
- Bacher G, Pool M, Dobberstein B (1999). "The Ribosome Regulates the Gtpase of the β-Subunit of the Signal Recognition Particle Receptor". J. Cell Biol. 146 (4): 723–30. doi:10.1083/jcb.146.4.723. PMC 2156146. PMID 10459008.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yan W, Wang WL, Zhu F, et al. (2003). "Isolation of a novel member of small G protein superfamily and its expression in colon cancer". World J. Gastroenterol. 9 (8): 1719–24. PMID 12918107.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Li Q, Yan W, Cheng S, et al. (2007). "Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21". Mol. Biol. Rep. 33 (4): 257–63. doi:10.1007/s11033-006-9007-9. PMID 17080297.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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