EGOT (gene): Difference between revisions
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'''EGOT''', also known as [[Eosinophil]] [[Granule (cell biology)|Granule]] [[Ontogeny]] (EGO)† [[Transcription (genetics)|Transcript]] ([[Non-coding RNA|non-protein coding]]),<ref name="pmid17351112">{{cite journal |vauthors=Wagner LA, Christensen CJ, Dunn DM |title=EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression |journal=Blood |volume=109 |issue=12 |pages=5191–8 |date=June 2007 |pmid=17351112 |pmc=1890841 |doi=10.1182/blood-2006-06-027987 |url=|display-authors=etal}}</ref> is a [[human]] [[gene]] at 3p26.1 that produces a [[long noncoding RNA]] molecule. EGOT is nested within an [[intron]] of the inositol triphosphate receptor type 1 ([[ITPR1]]) gene. The EGOT transcript is [[Gene expression|expressed]] during eosinophil development and is possibly involved in regulating eosinophil granule protein expression.<ref name="pmid17351112"/> Comparison of EGO-B, the spliced isoform, suggests EGOT may be conserved across placental mammals.<ref name="pmid22303364">{{cite journal |vauthors=Rose D, Stadler PF |title=Molecular evolution of the non-coding eosinophil granule ontogeny transcript |journal=Front Genet |volume=2|date=October 2011 |pmid=22303364 |pmc=3268622 |doi=10.3389/fgene.2011.00069 |url=}}</ref> | '''EGOT''', also known as [[Eosinophil]] [[Granule (cell biology)|Granule]] [[Ontogeny]] (EGO)† [[Transcription (genetics)|Transcript]] ([[Non-coding RNA|non-protein coding]]),<ref name="pmid17351112">{{cite journal |vauthors=Wagner LA, Christensen CJ, Dunn DM |title=EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression |journal=Blood |volume=109 |issue=12 |pages=5191–8 |date=June 2007 |pmid=17351112 |pmc=1890841 |doi=10.1182/blood-2006-06-027987 |url=|display-authors=etal}}</ref> is a [[human]] [[gene]] at 3p26.1 that produces a [[long noncoding RNA]] molecule. EGOT is nested within an [[intron]] of the inositol triphosphate receptor type 1 ([[ITPR1]]) gene. The EGOT transcript is [[Gene expression|expressed]] during eosinophil development and is possibly involved in regulating eosinophil granule protein expression.<ref name="pmid17351112"/> Comparison of EGO-B, the spliced isoform, suggests EGOT may be conserved across placental mammals.<ref name="pmid22303364">{{cite journal |vauthors=Rose D, Stadler PF |title=Molecular evolution of the non-coding eosinophil granule ontogeny transcript |journal=Front Genet |volume=2|date=October 2011 |pmid=22303364 |pmc=3268622 |doi=10.3389/fgene.2011.00069 |url=}}</ref> | ||
†Originally published as EGO but renamed as EGOT because 'EGO' is a real word and is therefore problematic when searching the scientific literature.<ref>{{cite journal|last1=Wright|first1=MW|title=A short guide to long non-coding RNA gene nomenclature.|journal=Human | †Originally published as EGO but renamed as EGOT because 'EGO' is a real word and is therefore problematic when searching the scientific literature.<ref>{{cite journal|last1=Wright|first1=MW|title=A short guide to long non-coding RNA gene nomenclature.|journal=Human Genomics|date=Apr 9, 2014|volume=8|pages=7|pmid=24716852|doi=10.1186/1479-7364-8-7|pmc=4021045}}</ref> | ||
== References == | == References == | ||
{{Reflist}} | {{Reflist}} | ||
[[Category: | [[Category:Genes on human chromosome 3]] | ||
[[Category:Non-coding RNA]] | [[Category:Non-coding RNA]] | ||
Latest revision as of 01:39, 25 September 2018
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EGOT, also known as Eosinophil Granule Ontogeny (EGO)† Transcript (non-protein coding),[1] is a human gene at 3p26.1 that produces a long noncoding RNA molecule. EGOT is nested within an intron of the inositol triphosphate receptor type 1 (ITPR1) gene. The EGOT transcript is expressed during eosinophil development and is possibly involved in regulating eosinophil granule protein expression.[1] Comparison of EGO-B, the spliced isoform, suggests EGOT may be conserved across placental mammals.[2]
†Originally published as EGO but renamed as EGOT because 'EGO' is a real word and is therefore problematic when searching the scientific literature.[3]
References
- ↑ 1.0 1.1 Wagner LA, Christensen CJ, Dunn DM, et al. (June 2007). "EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression". Blood. 109 (12): 5191–8. doi:10.1182/blood-2006-06-027987. PMC 1890841. PMID 17351112.
- ↑ Rose D, Stadler PF (October 2011). "Molecular evolution of the non-coding eosinophil granule ontogeny transcript". Front Genet. 2. doi:10.3389/fgene.2011.00069. PMC 3268622. PMID 22303364.
- ↑ Wright, MW (Apr 9, 2014). "A short guide to long non-coding RNA gene nomenclature". Human Genomics. 8: 7. doi:10.1186/1479-7364-8-7. PMC 4021045. PMID 24716852.