ARG1 (gene): Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
The human '''ARG1''' [[gene]] encodes the [[protein]] '''arginase'''.<ref name="entrez">{{cite web | title = Entrez Gene: Arginase, liver | url = https://www.ncbi.nlm.nih.gov/gene/383 }}</ref>


The human '''ARG1''' [[gene]] encodes the [[protein]] '''arginase'''.
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: Arginase, liver
| url = https://www.ncbi.nlm.nih.gov/gene/383
| accessdate = 2013-12-08 <!-- T09:57:25.841972-08:00 -->
}}</ref>
 
==Function==


[[Arginase]] [[Catalyst|catalyzes]] the [[hydrolysis]] of [[arginine]] to [[ornithine]] and [[urea]]. At least two [[isoform]]s of [[mammal]]ian arginase exist (types I and II) which differ in their [[Tissue (biology)|tissue]] distribution, subcellular localization, [[Immunology|immunologic]] crossreactivity and [[Physiology|physiologic]] function. The type I isoform encoded by this gene, is a [[cytosol]]ic enzyme and expressed predominantly in the [[liver]] as a component of the [[urea cycle]]. Inherited deficiency of this enzyme results in [[argininemia]], an [[autosomal recessive disorder]] characterized by [[hyperammonemia]]. Two [[Transcription (genetics)|transcript]] variants encoding different isoforms have been found for this gene.<ref>[provided by RefSeq, Sep 2011]</ref>
[[Arginase]] [[Catalyst|catalyzes]] the [[hydrolysis]] of [[arginine]] to [[ornithine]] and [[urea]]. At least two [[isoform]]s of [[mammal]]ian arginase exist (types I and II) which differ in their [[Tissue (biology)|tissue]] distribution, subcellular localization, [[Immunology|immunologic]] crossreactivity and [[Physiology|physiologic]] function. The type I isoform encoded by this gene, is a [[cytosol]]ic enzyme and expressed predominantly in the [[liver]] as a component of the [[urea cycle]]. Inherited deficiency of this enzyme results in [[argininemia]], an [[autosomal recessive disorder]] characterized by [[hyperammonemia]]. Two [[Transcription (genetics)|transcript]] variants encoding different isoforms have been found for this gene.<ref>[provided by RefSeq, Sep 2011]</ref>


== References ==
== References ==
{{reflist}}
{{reflist}}


==External links==
== External links ==
* {{UCSC gene info|ARG1}}
* {{UCSC gene info|ARG1}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal  
* {{cite journal | vauthors = Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris SM, Gladwin MT | title = Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease | journal = JAMA | volume = 294 | issue = 1 | pages = 81–90 | date = July 2005 | pmid = 15998894 | pmc = 2065861 | doi = 10.1001/jama.294.1.81 }}
| last1 = Morris | first1 = C. R.
* {{cite journal | vauthors = Jiang M, Ding Y, Su Y, Hu X, Li J, Zhang Z | title = Arginase-flotillin interaction brings arginase to red blood cell membrane | journal = FEBS Letters | volume = 580 | issue = 28–29 | pages = 6561–4 | date = December 2006 | pmid = 17113085 | pmc = | doi = 10.1016/j.febslet.2006.11.003 }}
| last2 = Kato | first2 = G. J.
* {{cite journal | vauthors = Morris SM | title = Recent advances in arginine metabolism: roles and regulation of the arginases | journal = British Journal of Pharmacology | volume = 157 | issue = 6 | pages = 922–30 | date = July 2009 | pmid = 19508396 | pmc = 2737650 | doi = 10.1111/j.1476-5381.2009.00278.x }}
| last3 = Poljakovic | first3 = M.
* {{cite journal | vauthors = Rotondo R, Bertolotto M, Barisione G, Astigiano S, Mandruzzato S, Ottonello L, Dallegri F, Bronte V, Ferrini S, Barbieri O | title = Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation | journal = Journal of Leukocyte Biology | volume = 89 | issue = 5 | pages = 721–7 | date = May 2011 | pmid = 21330347 | pmc = | doi = 10.1189/jlb.1109737 }}
| last4 = Wang | first4 = X.
* {{cite journal | vauthors = Shapiro MB, Senapathy P | title = RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression | journal = Nucleic Acids Research | volume = 15 | issue = 17 | pages = 7155–74 | date = September 1987 | pmid = 3658675 | pmc = 306199 | doi = 10.1093/nar/15.17.7155 }}
| last5 = Blackwelder | first5 = W. C.
* {{cite journal | vauthors = Rotondo R, Barisione G, Mastracci L, Grossi F, Orengo AM, Costa R, Truini M, Fabbi M, Ferrini S, Barbieri O | title = IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer | journal = International Journal of Cancer | volume = 125 | issue = 4 | pages = 887–93 | date = August 2009 | pmid = 19431148 | pmc = | doi = 10.1002/ijc.24448 }}
| last6 = Sachdev | first6 = V.
* {{cite journal | vauthors = Salam MT, Bastain TM, Rappaport EB, Islam T, Berhane K, Gauderman WJ, Gilliland FD | title = Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children | journal = Allergy | volume = 66 | issue = 3 | pages = 412–9 | date = March 2011 | pmid = 21039601 | pmc = 3058253 | doi = 10.1111/j.1398-9995.2010.02492.x }}
| last7 = Hazen | first7 = S. L.
* {{cite journal | vauthors = Gannon PO, Godin-Ethier J, Hassler M, Delvoye N, Aversa M, Poisson AO, Péant B, Alam Fahmy M, Saad F, Lapointe R, Mes-Masson AM | title = Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer | journal = PLOS One | volume = 5 | issue = 8 | pages = e12107 | date = August 2010 | pmid = 20711410 | pmc = 2920336 | doi = 10.1371/journal.pone.0012107 | editor1-last = Creighton | editor1-first = Chad }}
| last8 = Vichinsky | first8 = E. P.
* {{cite journal | vauthors = Ishikawa T, Harada T, Koi H, Kubota T, Azuma H, Aso T | title = Identification of arginase in human placental villi | journal = Placenta | volume = 28 | issue = 2–3 | pages = 133–8 | year = 2007 | pmid = 16720041 | pmc = | doi = 10.1016/j.placenta.2006.03.015 }}
| last9 = Morris Jr | first9 = S. M.
| last10 = Gladwin | first10 = M. T.
| title = Dysregulated Arginine Metabolism, Hemolysis-Associated Pulmonary Hypertension, and Mortality in Sickle Cell Disease
| doi = 10.1001/jama.294.1.81
| journal = JAMA  
| volume = 294  
| issue = 1  
| pages = 81–90  
| year = 2005  
| pmid = 15998894  
| pmc =2065861  
}}
*{{Cite journal  
| last1 = Jiang | first1 = M.
| last2 = Ding | first2 = Y.
| last3 = Su | first3 = Y.
| last4 = Hu | first4 = X.
| last5 = Li | first5 = J.
| last6 = Zhang | first6 = Z.
| doi = 10.1016/j.febslet.2006.11.003
| title = Arginase-flotillin interaction brings arginase to red blood cell membrane  
| journal = FEBS Letters  
| volume = 580  
| issue = 28–29  
| pages = 6561–6564
| year = 2006  
| pmid = 17113085  
| pmc =  
}}
*{{Cite journal  
| last1 = Morris Jr | first1 = S. M.
| title = Recent advances in arginine metabolism: Roles and regulation of the arginases  
| doi = 10.1111/j.1476-5381.2009.00278.x
| journal = British Journal of Pharmacology  
| volume = 157  
| issue = 6  
| pages = 922–930
| year = 2009  
| pmid = 19508396  
| pmc =2737650  
}}
*{{Cite journal  
| last1 = Rotondo | first1 = R.
| last2 = Bertolotto | first2 = M.
| last3 = Barisione | first3 = G.
| last4 = Astigiano | first4 = S.
| last5 = Mandruzzato | first5 = S.
| last6 = Ottonello | first6 = L.
| last7 = Dallegri | first7 = F.
| last8 = Bronte | first8 = V.
| last9 = Ferrini | first9 = S.
| last10 = Barbieri | first10 = O.
| doi = 10.1189/jlb.1109737
| title = Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation  
| journal = Journal of Leukocyte Biology  
| volume = 89  
| issue = 5  
| pages = 721–727
| year = 2011  
| pmid = 21330347  
| pmc =  
}}
*{{Cite journal
| doi = 10.1093/nar/15.17.7155
| last1 = Shapiro | first1 = M. B.
| last2 = Senapathy | first2 = P.
| title = RNA splice junctions of different classes of eukaryotes: Sequence statistics and functional implications in gene expression  
| journal = Nucleic Acids Research  
| volume = 15  
| issue = 17  
| pages = 7155–7174
| year = 1987  
| pmid = 3658675  
| pmc = 306199
}}
*{{Cite journal  
| last1 = Rotondo | first1 = R.
| last2 = Barisione | first2 = G.
| last3 = Mastracci | first3 = L.
| last4 = Grossi | first4 = F.
| last5 = Orengo | first5 = A. M.
| last6 = Costa | first6 = R.
| last7 = Truini | first7 = M.
| last8 = Fabbi | first8 = M.
| last9 = Ferrini | first9 = S.
| last10 = Barbieri | first10 = O.
| doi = 10.1002/ijc.24448
| title = IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer  
| journal = International Journal of Cancer  
| volume = 125  
| issue = 4  
| pages = 887–893
| year = 2009  
| pmid = 19431148  
| pmc =  
}}
*{{Cite journal  
| last1 = Salam | first1 = M. T.
| last2 = Bastain | first2 = T. M.
| last3 = Rappaport | first3 = E. B.
| last4 = Islam | first4 = T.
| last5 = Berhane | first5 = K.
| last6 = Gauderman | first6 = W. J.
| last7 = Gilliland | first7 = F. D.
| doi = 10.1111/j.1398-9995.2010.02492.x
| title = Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children  
| journal = Allergy  
| volume = 66  
| issue = 3  
| pages = 412–419
| year = 2011  
| pmid = 21039601  
| pmc =3058253  
}}
*{{Cite journal  
| last1 = Gannon | first1 = P. O.
| last2 = Godin-Ethier | first2 = J.
| last3 = Hassler | first3 = M.
| last4 = Delvoye | first4 = N.
| last5 = Aversa | first5 = M.
| last6 = Poisson | first6 = A. O.
| last7 = Péant | first7 = B.
| last8 = Alam Fahmy | first8 = M.
| last9 = Saad | first9 = F.
| last10 = Lapointe | first10 = R. J.
| last11 = Mes-Masson | first11 = A. M.
| editor1-last = Creighton
| editor1-first = Chad
| title = Androgen-Regulated Expression of Arginase 1, Arginase 2 and Interleukin-8 in Human Prostate Cancer
| doi = 10.1371/journal.pone.0012107
| journal = PLoS ONE
| volume = 5  
| issue = 8  
| pages = e12107  
| year = 2010  
| pmid = 20711410  
| pmc =2920336  
}}
*{{Cite journal  
| last1 = Ishikawa | first1 = T.
| last2 = Harada | first2 = T.
| last3 = Koi | first3 = H.
| last4 = Kubota | first4 = T.
| last5 = Azuma | first5 = H.
| last6 = Aso | first6 = T.
| doi = 10.1016/j.placenta.2006.03.015
| title = Identification of Arginase in Human Placental Villi
| journal = Placenta  
| volume = 28  
| issue = 2–3  
| pages = 133–138
| year = 2007  
| pmid = 16720041  
| pmc =  
}}
 
{{refend}}
{{refend}}


Latest revision as of 04:31, 11 August 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

The human ARG1 gene encodes the protein arginase.[1]

Function

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. ↑ "Entrez Gene: Arginase, liver".
  2. ↑ [provided by RefSeq, Sep 2011]

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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