HECW1: Difference between revisions
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'''HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1''' is a [[protein]] that in humans is encoded by the HECW1 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | url = https://www.ncbi.nlm.nih.gov/gene/23072 }}</ref> In human it has 1606 [[amino acid]]s (179.5 kDa) and [[isoelectric point]] of 5.18.<ref name="Kozlowski">{{cite journal | vauthors = Kozlowski LP | title = IPC - Isoelectric Point Calculator | journal = Biology Direct | volume = 11 | issue = 1 | pages = 55 | date = October 2016 | pmid = 27769290 | doi = 10.1186/s13062-016-0159-9 | url = http://isoelectric.ovh.org }}</ref> | '''HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1''' is a [[protein]] that in humans is encoded by the HECW1 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | url = https://www.ncbi.nlm.nih.gov/gene/23072 }}</ref> In human it has 1606 [[amino acid]]s (179.5 kDa) and [[isoelectric point]] of 5.18.<ref name="Kozlowski">{{cite journal | vauthors = Kozlowski LP | title = IPC - Isoelectric Point Calculator | journal = Biology Direct | volume = 11 | issue = 1 | pages = 55 | date = October 2016 | pmid = 27769290 | doi = 10.1186/s13062-016-0159-9 | url = http://isoelectric.ovh.org | pmc=5075173}}</ref> | ||
== References == | == References == | ||
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{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A | title = NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 12 | pages = 11327–35 | date = March 2004 | pmid = 14684739 | doi = 10.1074/jbc.M312389200 }} | * {{cite journal | vauthors = Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A | title = NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 12 | pages = 11327–35 | date = March 2004 | pmid = 14684739 | doi = 10.1074/jbc.M312389200 }} | ||
* {{cite journal | vauthors = Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le HT, Park SK, Nguyen MD | title = The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity | journal = | * {{cite journal | vauthors = Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le HT, Park SK, Nguyen MD | title = The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity | journal = PLOS ONE | volume = 6 | issue = 1 | pages = e14583 | date = January 2011 | pmid = 21283621 | pmc = 3026782 | doi = 10.1371/journal.pone.0014583 }} | ||
* {{cite journal | vauthors = Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC | title = Genome-wide association study of the rate of cognitive decline in Alzheimer's disease | journal = Alzheimer's & Dementia | volume = 10 | issue = 1 | pages = 45–52 | date = January 2014 | pmid = 23535033 | pmc = 3760995 | doi = 10.1016/j.jalz.2013.01.008 | author13 = Alzheimer's Disease Neuroimaging Initiative | author14 = Alzheimer's Disease Genetics Consortium }} | * {{cite journal | vauthors = Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC | title = Genome-wide association study of the rate of cognitive decline in Alzheimer's disease | journal = Alzheimer's & Dementia | volume = 10 | issue = 1 | pages = 45–52 | date = January 2014 | pmid = 23535033 | pmc = 3760995 | doi = 10.1016/j.jalz.2013.01.008 | author13 = Alzheimer's Disease Neuroimaging Initiative | author14 = Alzheimer's Disease Genetics Consortium }} | ||
* {{cite journal | vauthors = Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A | title = A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner | journal = Oncogene | volume = 27 | issue = 26 | pages = 3700–9 | date = June 2008 | pmid = 18223681 | doi = 10.1038/sj.onc.1211032 }} | * {{cite journal | vauthors = Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A | title = A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner | journal = Oncogene | volume = 27 | issue = 26 | pages = 3700–9 | date = June 2008 | pmid = 18223681 | doi = 10.1038/sj.onc.1211032 }} | ||
Latest revision as of 13:15, 5 March 2018
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HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene.[1] In human it has 1606 amino acids (179.5 kDa) and isoelectric point of 5.18.[2]
References
- ↑ "Entrez Gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1".
- ↑ Kozlowski LP (October 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi:10.1186/s13062-016-0159-9. PMC 5075173. PMID 27769290.
Further reading
- Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A (March 2004). "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1". The Journal of Biological Chemistry. 279 (12): 11327–35. doi:10.1074/jbc.M312389200. PMID 14684739.
- Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le HT, Park SK, Nguyen MD (January 2011). "The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity". PLOS ONE. 6 (1): e14583. doi:10.1371/journal.pone.0014583. PMC 3026782. PMID 21283621.
- Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC (January 2014). "Genome-wide association study of the rate of cognitive decline in Alzheimer's disease". Alzheimer's & Dementia. 10 (1): 45–52. doi:10.1016/j.jalz.2013.01.008. PMC 3760995. PMID 23535033.
- Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A (June 2008). "A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner". Oncogene. 27 (26): 3700–9. doi:10.1038/sj.onc.1211032. PMID 18223681.
- Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". The Journal of Biological Chemistry. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092.
- Zhang L, Haraguchi S, Koda T, Hashimoto K, Nakagawara A (2011). "Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice". Journal of Biomedicine & Biotechnology. 2011: 831092. doi:10.1155/2011/831092. PMC 2952905. PMID 20976258.
- Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L (May 2011). "SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1". The EMBO Journal. 30 (13): 2675–89. doi:10.1038/emboj.2011.155. PMC 3155294. PMID 21572392.
- Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S (January 2011). "RNF43 interacts with NEDL1 and regulates p53-mediated transcription". Biochemical and Biophysical Research Communications. 404 (1): 143–7. doi:10.1016/j.bbrc.2010.11.082. PMID 21108931.
- Levine DM, Ek WE, Zhang R, Liu X, Onstad L, Sather C, Lao-Sirieix P, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Murray LJ, Reid BJ, Chow WH, Risch HA, Nyrén O, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Chanock SJ, Harrington P, Caldas I, Debiram-Beecham I, Caldas C, Hayward NK, Pharoah PD, Fitzgerald RC, Macgregor S, Whiteman DC, Vaughan TL (December 2013). "A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus". Nature Genetics. 45 (12): 1487–93. doi:10.1038/ng.2796. PMC 3840115. PMID 24121790.
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