Myod family inhibitor domain containing: Difference between revisions

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==Function==
==Function==


This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants.
This [[gene product]] is a member of a family of proteins characterized by a specific [[cysteine]]-rich C-terminal domain, which is involved in [[transcriptional regulation]] of [[Virus|viral]] genome [[Gene expression|expression]]. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two [[isoforms]], p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the [[cytoplasm]], whereas p40 is targeted to the [[nucleolus]]. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. [[Alternative splicing]] results in multiple transcript variants.


== References ==
== References ==

Latest revision as of 19:01, 27 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

MyoD family inhibitor domain containing is a protein that in humans is encoded by the MDFIC gene. [1]

Function

This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants.

References

  1. ↑ "Entrez Gene: MyoD family inhibitor domain containing". Retrieved 2016-02-09.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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