YIPF6: Difference between revisions
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'''Protein YIPF6''' is a [[protein]] that in humans is encoded by the ''YIPF6'' [[gene]].<ref name="pmid12477932">{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA |display-authors=3| title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 26 | pages = 16899–16903 |date=Dec 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: YIPF6 Yip1 domain family, member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=286451| accessdate = }}</ref> | '''Protein YIPF6''' is a [[protein]] that in humans is encoded by the ''YIPF6'' [[gene]].<ref name="pmid12477932">{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA |display-authors=3| title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 26 | pages = 16899–16903 |date=Dec 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: YIPF6 Yip1 domain family, member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=286451| accessdate = }}</ref> | ||
In mice, a [[null allele]] of YIPF6 has been found to cause intestinal inflammation resulting in spontaneous colitis and ileitis by impairing intestinal homeostasis. The impairment was due to defects in the formation and secretion of large secretory [[Granule (cell biology)|granules]] from [[goblet cell|goblet]] and [[Paneth cell|Paneth]] cells.<ref name=pnas109>{{cite journal|title=Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice |journal=Proceedings of the National Academy of Sciences |volume=109 |number=31 |date=July 2012 |last1=Brandl |first1=Katherina |last2=Tomisato |first2=Wataru |last3=Li |first3=Xiaohong |last4=Neppi |first4=Christina |last5=Pirie |first5=Elaine |last6=Falk |first6=Werner |last7=Yu |first7=Xia |last8=Moresco |first8=Eva Marie Y. |last9=Baccala |first9=Roberto |last10=Theofilopoulos |first10=Argyrios N. |last11=Schnabl |first11=Bernd |last12=Beutler |first12=Bruce |display-authors=3 | In mice, a [[null allele]] of YIPF6 has been found to cause intestinal inflammation resulting in spontaneous colitis and ileitis by impairing intestinal homeostasis. The impairment was due to defects in the formation and secretion of large secretory [[Granule (cell biology)|granules]] from [[goblet cell|goblet]] and [[Paneth cell|Paneth]] cells.<ref name=pnas109>{{cite journal|title=Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice |journal=Proceedings of the National Academy of Sciences |volume=109 |number=31 |date=July 2012 |last1=Brandl |first1=Katherina |last2=Tomisato |first2=Wataru |last3=Li |first3=Xiaohong |last4=Neppi |first4=Christina |last5=Pirie |first5=Elaine |last6=Falk |first6=Werner |last7=Yu |first7=Xia |last8=Moresco |first8=Eva Marie Y. |last9=Baccala |first9=Roberto |last10=Theofilopoulos |first10=Argyrios N. |last11=Schnabl |first11=Bernd |last12=Beutler |first12=Bruce |display-authors=3 |doi=10.1073/pnas.1210366109 |pmc=3412000 |pmid=22802641 |pages=12650–12655}}</ref> Because the [[Sex linkage|X-linked]] YIPF6 mutation resulted in spontaneous disease, it has been suggested that it may increase susceptibility to [[inflammatory bowel disease]] in humans, particularly in males.<ref name=pnas109 /><ref>{{cite journal|title=Linking membrane trafficking and intestinal homeostasis |last1=Moresco |first1=Eva Marie Y. |last2=Brandl |first2=Katherina |journal=Tissue Barriers |volume=1 |number=1 |date=January 2013 |doi=10.4161/tisb.23119 |pmc=3875636 |pmid=24665373 |page=e23119}}</ref> | ||
==References== | ==References== | ||
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*{{cite journal | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–D418 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |name-list-format=vanc| author2=Rosenfelder H | author3=Schupp I | display-authors=3 | last4=Del Val | first4=C | last5=Arlt | first5=D | last6=Hahne | first6=F | last7=Bechtel | first7=S | last8=Simpson | first8=J | last9=Hofmann | first9=O }} | *{{cite journal | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–D418 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |name-list-format=vanc| author2=Rosenfelder H | author3=Schupp I | display-authors=3 | last4=Del Val | first4=C | last5=Arlt | first5=D | last6=Hahne | first6=F | last7=Bechtel | first7=S | last8=Simpson | first8=J | last9=Hofmann | first9=O }} | ||
{{refend}} | {{refend}} | ||
{{gene-X-stub}} | {{gene-X-stub}} | ||
Latest revision as of 18:26, 3 March 2018
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Protein YIPF6 is a protein that in humans is encoded by the YIPF6 gene.[1][2]
In mice, a null allele of YIPF6 has been found to cause intestinal inflammation resulting in spontaneous colitis and ileitis by impairing intestinal homeostasis. The impairment was due to defects in the formation and secretion of large secretory granules from goblet and Paneth cells.[3] Because the X-linked YIPF6 mutation resulted in spontaneous disease, it has been suggested that it may increase susceptibility to inflammatory bowel disease in humans, particularly in males.[3][4]
References
- ↑ Strausberg RL, Feingold EA, Grouse LH, et al. (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- ↑ "Entrez Gene: YIPF6 Yip1 domain family, member 6".
- ↑ 3.0 3.1 Brandl, Katherina; Tomisato, Wataru; Li, Xiaohong; et al. (July 2012). "Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice". Proceedings of the National Academy of Sciences. 109 (31): 12650–12655. doi:10.1073/pnas.1210366109. PMC 3412000. PMID 22802641.
- ↑ Moresco, Eva Marie Y.; Brandl, Katherina (January 2013). "Linking membrane trafficking and intestinal homeostasis". Tissue Barriers. 1 (1): e23119. doi:10.4161/tisb.23119. PMC 3875636. PMID 24665373.
Further reading
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–337. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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