SH3KBP1: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''SH3 domain-containing kinase-binding protein 1''' is an [[enzyme]] that in humans is encoded by the ''SH3KBP1'' [[gene]].<ref name="pmid8889549">{{cite journal |author1=Hillier LD |author2=Lennon G |author3=Becker M |author4=Bonaldo MF |author5=Chiapelli B |author6=Chissoe S |author7=Dietrich N |author8=DuBuque T |author9=Favello A |author10=Gish W |author11=Hawkins M |author12=Hultman M |author13=Kucaba T |author14=Lacy M |author15=Le M |author16=Le N |author17=Mardis E |author18=Moore B |author19=Morris M |author20=Parsons J |author21=Prange C |author22=Rifkin L |author23=Rohlfing T |author24=Schellenberg K |author25=Bento Soares M |author26=Tan F |author27=Thierry-Meg J |author28=Trevaskis E |author29=Underwood K |author30=Wohldman P |author31=Waterston R |author32=Wilson R |author33=Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Res | volume = 6 | issue = 9 | pages = 807–28 |date=May 1997 | pmid = 8889549 | pmc =  | doi =10.1101/gr.6.9.807 }}</ref><ref name="pmid7566098">{{cite journal |vauthors=Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O, etal | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 |date=November 1995 | pmid = 7566098 | pmc =  | doi =<!-- none available --> |url=http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format=PDF   }}</ref>
'''SH3 domain-containing kinase-binding protein 1 (synonims - CIN85'''<ref>{{Cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=SH3KBP1|title=SH3KBP1 Gene - GeneCards {{!}} SH3K1 Protein {{!}} SH3K1 Antibody|last=Database|first=GeneCards Human Gene|website=www.genecards.org|access-date=2017-12-28}}</ref>''', in rodents - Ruk'''<ref>{{cite journal | vauthors = Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL | title = Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein | journal = The EMBO Journal | volume = 19 | issue = 15 | pages = 4015–25 | date = August 2000 | pmid = 10921882 | doi = 10.1093/emboj/19.15.4015 | pmc = 306608 }}</ref>''')''' is an [[Signal transducing adaptor protein|adaptor protein]] that in humans is encoded by the ''SH3KBP1'' [[gene]].<ref name="pmid8889549">{{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | display-authors = 6 | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Research | volume = 6 | issue = 9 | pages = 807–28 | date = September 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 }}</ref><ref name="pmid7566098">{{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | date = September 1995 | pmid = 7566098 | doi = <!-- none available --> | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format = PDF }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SH3KBP1 SH3-domain kinase binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30011| accessdate = }}</ref>
}}


==Interactions==
CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SH3KBP1 SH3-domain kinase binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30011| accessdate = }}</ref>
SH3KBP1 has been shown to [[Protein-protein interaction|interact]] with [[B-cell linker]],<ref name=pmid11071869>{{cite journal |last=Watanabe |first=S |authorlink= |author2=Take H |author3=Takeda K |author4=Yu Z X |author5=Iwata N |author6=Kajigaya S  |date=November 2000  |title=Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue=1 |pages=167–74 |publisher= |location = UNITED STATES| issn = 0006-291X| pmid = 11071869 |doi = 10.1006/bbrc.2000.3760 }}</ref> [[Grb2]],<ref name=pmid10921882>{{cite journal |last=Gout |first=I |authorlink= |author2=Middleton G |author3=Adu J |author4=Ninkina N N |author5=Drobot L B |author6=Filonenko V |author7=Matsuka G |author8=Davies A M |author9=Waterfield M |author10=Buchman V L  |date=August 2000  |title=Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein |journal=EMBO J. |volume=19 |issue=15 |pages=4015–25 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 10921882 |doi = 10.1093/emboj/19.15.4015 |pmc=306608 }}</ref><ref name=pmid11152963>{{cite journal |last=Borinstein |first=S C |authorlink= |author2=Hyatt M A |author3=Sykes V W |author4=Straub R E |author5=Lipkowitz S |author6=Boulter J |author7=Bogler O  |date=December 2000  |title=SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins |journal=Cell. Signal. |volume=12 |issue=11–12 |pages=769–79 |publisher= |location = ENGLAND| issn = 0898-6568| pmid = 11152963 |doi=10.1016/S0898-6568(00)00129-7 }}</ref> [[SH3GLB2]],<ref name=pmid11894096>{{cite journal |last=Petrelli |first=Annalisa |authorlink= |author2=Gilestro Giorgio F |author3=Lanzardo Stefania |author4=Comoglio Paolo M |author5=Migone Nicola |author6=Giordano Silvia  |date=March 2002  |title=The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met |journal=[[Nature (journal)|Nature]] |volume=416 |issue=6877 |pages=187–90 |publisher= |location = England| issn = 0028-0836| pmid = 11894096 |doi = 10.1038/416187a  }}</ref><ref name=pmid11894095>{{cite journal |last=Soubeyran |first=Philippe |authorlink= |author2=Kowanetz Katarzyna |author3=Szymkiewicz Iwona |author4=Langdon Wallace Y |author5=Dikic Ivan  |date=March 2002  |title=Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors |journal=[[Nature (journal)|Nature]] |volume=416 |issue=6877 |pages=183–7 |publisher= |location = England| issn = 0028-0836| pmid = 11894095 |doi = 10.1038/416183a  }}</ref> [[SH3GL3]],<ref name=pmid11894096/> [[SH3GL2]],<ref name=pmid11894095/> [[BCAR1]],<ref name=pmid11071869/> [[Epidermal growth factor receptor]],<ref name=pmid11894095/><ref name=pmid12177062>{{cite journal |last=Szymkiewicz |first=Iwona |authorlink= |author2=Kowanetz Katarzyna |author3=Soubeyran Philippe |author4=Dinarina Ana |author5=Lipkowitz Stanley |author6=Dikic Ivan  |date=October 2002  |title=CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases |journal=J. Biol. Chem. |volume=277 |issue=42 |pages=39666–72 |publisher= |location = United States| issn = 0021-9258| pmid = 12177062 |doi = 10.1074/jbc.M205535200 }}</ref> [[CBLB (genetics)|CBLB]],<ref name=pmid12177062/> [[Cbl gene]],<ref name=pmid11071869/><ref name=pmid11152963/><ref name=pmid11894096/><ref name=pmid11894095/><ref name=pmid12177062/> [[SOS1]],<ref name=pmid11071869/> [[CRK (gene)|CRK]]<ref name=pmid11071869/> and [[PAK2]].<ref name=pmid12829691>{{cite journal |last=Kurakin |first=Alexei V |authorlink= |author2=Wu Susan |author3=Bredesen Dale E  |date=September 2003  |title=Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening |journal=J. Biol. Chem. |volume=278 |issue=36 |pages=34102–9 |publisher= |location = United States| issn = 0021-9258| pmid = 12829691 |doi = 10.1074/jbc.M305264200 }}</ref>


==References==
== Interactions ==
 
SH3KBP1 has been shown to [[Protein-protein interaction|interact]] with [[B-cell linker]],<ref name=pmid11071869>{{cite journal | vauthors = Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S | title = Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes | journal = Biochemical and Biophysical Research Communications | volume = 278 | issue = 1 | pages = 167–74 | date = November 2000 | pmid = 11071869 | doi = 10.1006/bbrc.2000.3760 }}</ref> [[Grb2]],<ref name=pmid10921882>{{cite journal | vauthors = Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL | title = Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein | journal = The EMBO Journal | volume = 19 | issue = 15 | pages = 4015–25 | date = August 2000 | pmid = 10921882 | pmc = 306608 | doi = 10.1093/emboj/19.15.4015 }}</ref><ref name=pmid11152963>{{cite journal | vauthors = Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O | title = SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins | journal = Cellular Signalling | volume = 12 | issue = 11-12 | pages = 769–79 | date = December 2000 | pmid = 11152963 | doi = 10.1016/S0898-6568(00)00129-7 }}</ref> [[SH3GLB2]],<ref name=pmid11894096>{{cite journal | vauthors = Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S | title = The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met | journal = Nature | volume = 416 | issue = 6877 | pages = 187–90 | date = March 2002 | pmid = 11894096 | doi = 10.1038/416187a }}</ref><ref name=pmid11894095>{{cite journal | vauthors = Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I | title = Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors | journal = Nature | volume = 416 | issue = 6877 | pages = 183–7 | date = March 2002 | pmid = 11894095 | doi = 10.1038/416183a }}</ref> [[SH3GL3]],<ref name=pmid11894096/> [[SH3GL2]],<ref name=pmid11894095/> [[BCAR1]],<ref name=pmid11071869/> [[Epidermal growth factor receptor]],<ref name=pmid11894095/><ref name=pmid12177062>{{cite journal | vauthors = Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I | title = CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 42 | pages = 39666–72 | date = October 2002 | pmid = 12177062 | doi = 10.1074/jbc.M205535200 }}</ref> [[CBLB (genetics)|CBLB]],<ref name=pmid12177062/> [[Cbl gene]],<ref name=pmid11071869/><ref name=pmid11152963/><ref name=pmid11894096/><ref name=pmid11894095/><ref name=pmid12177062/> [[SOS1]],<ref name=pmid11071869/> [[CRK (gene)|CRK]]<ref name=pmid11071869/> and [[PAK2]].<ref name=pmid12829691>{{cite journal | vauthors = Kurakin AV, Wu S, Bredesen DE | title = Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening | journal = The Journal of Biological Chemistry | volume = 278 | issue = 36 | pages = 34102–9 | date = September 2003 | pmid = 12829691 | doi = 10.1074/jbc.M305264200 }}</ref>
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Salvatore P, Hanash CR, Kido Y, Imai Y, Accili D | title = Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN | journal = The Journal of Biological Chemistry | volume = 273 | issue = 12 | pages = 6989–97 | date = March 1998 | pmid = 9507006 | doi = 10.1074/jbc.273.12.6989 }}
| citations =
* {{cite journal | vauthors = Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL | title = A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion | journal = The EMBO Journal | volume = 17 | issue = 24 | pages = 7320–36 | date = December 1998 | pmid = 9857189 | pmc = 1171078 | doi = 10.1093/emboj/17.24.7320 }}
*{{cite journal   |vauthors=Salvatore P, Hanash CR, Kido Y, etal |title=Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6989–97 |year= 1998 |pmid= 9507006 |doi=10.1074/jbc.273.12.6989 }}
* {{cite journal | vauthors = Take H, Watanabe S, Takeda K, Yu ZX, Iwata N, Kajigaya S | title = Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl | journal = Biochemical and Biophysical Research Communications | volume = 268 | issue = 2 | pages = 321–8 | date = February 2000 | pmid = 10679202 | doi = 10.1006/bbrc.2000.2147 }}
*{{cite journal   |vauthors=Li J, Nishizawa K, An W, etal |title=A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion |journal=EMBO J. |volume=17 |issue= 24 |pages= 7320–36 |year= 1999 |pmid= 9857189 |doi= 10.1093/emboj/17.24.7320 | pmc=1171078 }}
* {{cite journal | vauthors = Chen B, Borinstein SC, Gillis J, Sykes VW, Bogler O | title = The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes | journal = The Journal of Biological Chemistry | volume = 275 | issue = 25 | pages = 19275–81 | date = June 2000 | pmid = 10858458 | doi = 10.1074/jbc.M908994199 }}
*{{cite journal   |vauthors=Take H, Watanabe S, Takeda K, etal |title=Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 321–8 |year= 2000 |pmid= 10679202 |doi= 10.1006/bbrc.2000.2147 }}
* {{cite journal | vauthors = Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL | title = Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein | journal = The EMBO Journal | volume = 19 | issue = 15 | pages = 4015–25 | date = August 2000 | pmid = 10921882 | pmc = 306608 | doi = 10.1093/emboj/19.15.4015 }}
*{{cite journal   |vauthors=Chen B, Borinstein SC, Gillis J, etal |title=The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 19275–81 |year= 2000 |pmid= 10858458 |doi= 10.1074/jbc.M908994199 }}
* {{cite journal | vauthors = Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S | title = Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes | journal = Biochemical and Biophysical Research Communications | volume = 278 | issue = 1 | pages = 167–74 | date = November 2000 | pmid = 11071869 | doi = 10.1006/bbrc.2000.3760 }}
*{{cite journal   |vauthors=Gout I, Middleton G, Adu J, etal |title=Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein |journal=EMBO J. |volume=19 |issue= 15 |pages= 4015–25 |year= 2000 |pmid= 10921882 |doi= 10.1093/emboj/19.15.4015 | pmc=306608 }}
* {{cite journal | vauthors = Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O | title = SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins | journal = Cellular Signalling | volume = 12 | issue = 11-12 | pages = 769–79 | date = December 2000 | pmid = 11152963 | doi = 10.1016/S0898-6568(00)00129-7 }}
*{{cite journal   |vauthors=Watanabe S, Take H, Takeda K, etal |title=Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 1 |pages= 167–74 |year= 2001 |pmid= 11071869 |doi= 10.1006/bbrc.2000.3760 }}
* {{cite journal | vauthors = Narita T, Amano F, Yoshizaki K, Nishimoto N, Nishimura T, Tajima T, Namiki H, Taniyama T | title = Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 93 | issue = 1-2 | pages = 133–4 | year = 2001 | pmid = 11474197 | doi = 10.1159/000056966 }}
*{{cite journal   |vauthors=Borinstein SC, Hyatt MA, Sykes VW, etal |title=SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins |journal=Cell. Signal. |volume=12 |issue= 11–12 |pages= 769–79 |year= 2001 |pmid= 11152963 |doi=10.1016/S0898-6568(00)00129-7 }}
* {{cite journal | vauthors = Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I | title = Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors | journal = Nature | volume = 416 | issue = 6877 | pages = 183–7 | date = March 2002 | pmid = 11894095 | doi = 10.1038/416183a }}
*{{cite journal   |vauthors=Narita T, Amano F, Yoshizaki K, etal |title=Assignment of SH3KBP1 to human chromosome band Xp22.1→p21.3 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=93 |issue= 1–2 |pages= 133–4 |year= 2001 |pmid= 11474197 |doi=10.1159/000056966 }}
* {{cite journal | vauthors = Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S | title = The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met | journal = Nature | volume = 416 | issue = 6877 | pages = 187–90 | date = March 2002 | pmid = 11894096 | doi = 10.1038/416187a }}
*{{cite journal   |vauthors=Soubeyran P, Kowanetz K, Szymkiewicz I, etal |title=Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors |journal=Nature |volume=416 |issue= 6877 |pages= 183–7 |year= 2002 |pmid= 11894095 |doi= 10.1038/416183a }}
* {{cite journal | vauthors = Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT | title = Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 28238–46 | date = August 2002 | pmid = 12029088 | doi = 10.1074/jbc.M202783200 }}
*{{cite journal   |vauthors=Petrelli A, Gilestro GF, Lanzardo S, etal |title=The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met |journal=Nature |volume=416 |issue= 6877 |pages= 187–90 |year= 2002 |pmid= 11894096 |doi= 10.1038/416187a }}
* {{cite journal | vauthors = Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M, Gout I | title = Ruk is ubiquitinated but not degraded by the proteasome | journal = European Journal of Biochemistry | volume = 269 | issue = 14 | pages = 3402–8 | date = July 2002 | pmid = 12135478 | doi = 10.1046/j.1432-1033.2002.03031.x }}
*{{cite journal   |vauthors=Scott MP, Zappacosta F, Kim EY, etal |title=Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28238–46 |year= 2002 |pmid= 12029088 |doi= 10.1074/jbc.M202783200 }}
* {{cite journal | vauthors = Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I | title = CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 42 | pages = 39666–72 | date = October 2002 | pmid = 12177062 | doi = 10.1074/jbc.M205535200 }}
*{{cite journal   |vauthors=Verdier F, Valovka T, Zhyvoloup A, etal |title=Ruk is ubiquitinated but not degraded by the proteasome |journal=Eur. J. Biochem. |volume=269 |issue= 14 |pages= 3402–8 |year= 2002 |pmid= 12135478 |doi=10.1046/j.1432-1033.2002.03031.x }}
* {{cite journal | vauthors = Haglund K, Shimokawa N, Szymkiewicz I, Dikic I | title = Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 19 | pages = 12191–6 | date = September 2002 | pmid = 12218189 | pmc = 129420 | doi = 10.1073/pnas.192462299 }}
*{{cite journal   |vauthors=Szymkiewicz I, Kowanetz K, Soubeyran P, etal |title=CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39666–72 |year= 2002 |pmid= 12177062 |doi= 10.1074/jbc.M205535200 }}
* {{cite journal | vauthors = Buchman VL, Luke C, Borthwick EB, Gout I, Ninkina N | title = Organization of the mouse Ruk locus and expression of isoforms in mouse tissues | journal = Gene | volume = 295 | issue = 1 | pages = 13–17 | date = July 2002 | pmid = 12242006 | doi = 10.1016/S0378-1119(02)00821-1 }}
*{{cite journal |author1=Haglund K |author2=Shimokawa N |author3=Szymkiewicz I |author4=Dikic I |title=Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 19 |pages= 12191–6 |year= 2002 |pmid= 12218189 |doi= 10.1073/pnas.192462299 | pmc=129420 }}
* {{cite journal | vauthors = Tibaldi EV, Reinherz EL | title = CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities | journal = International Immunology | volume = 15 | issue = 3 | pages = 313–29 | date = March 2003 | pmid = 12618476 | doi = 10.1093/intimm/dxg032 }}
*{{cite journal   |vauthors=Buchman VL, Luke C, Borthwick EB, etal |title=Organization of the mouse Ruk locus and expression of isoforms in mouse tissues |journal=Gene |volume=295 |issue= 1 |pages= 13–17 |year= 2003 |pmid= 12242006 |doi=10.1016/S0378-1119(02)00821-1 }}
* {{cite journal | vauthors = Hutchings NJ, Clarkson N, Chalkley R, Barclay AN, Brown MH | title = Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 25 | pages = 22396–403 | date = June 2003 | pmid = 12690097 | doi = 10.1074/jbc.M302540200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |author1=Tibaldi EV |author2=Reinherz EL |title=CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities |journal=Int. Immunol. |volume=15 |issue= 3 |pages= 313–29 |year= 2003 |pmid= 12618476 |doi=10.1093/intimm/dxg032 }}
*{{cite journal   |vauthors=Hutchings NJ, Clarkson N, Chalkley R, etal |title=Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85 |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22396–403 |year= 2003 |pmid= 12690097 |doi= 10.1074/jbc.M302540200 }}
}}
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{{refend}}
{{PDB Gallery|geneid=30011}}
{{PDB Gallery|geneid=30011}}
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Revision as of 00:31, 24 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

SH3 domain-containing kinase-binding protein 1 (synonims - CIN85[1], in rodents - Ruk[2]) is an adaptor protein that in humans is encoded by the SH3KBP1 gene.[3][4]

Function

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM][5]

Interactions

SH3KBP1 has been shown to interact with B-cell linker,[6] Grb2,[7][8] SH3GLB2,[9][10] SH3GL3,[9] SH3GL2,[10] BCAR1,[6] Epidermal growth factor receptor,[10][11] CBLB,[11] Cbl gene,[6][8][9][10][11] SOS1,[6] CRK[6] and PAK2.[12]

References

  1. ↑ Database, GeneCards Human Gene. "SH3KBP1 Gene - GeneCards | SH3K1 Protein | SH3K1 Antibody". www.genecards.org. Retrieved 2017-12-28.
  2. ↑ Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. PMC 306608. PMID 10921882.
  3. ↑ Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, et al. (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  4. ↑ Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
  5. ↑ "Entrez Gene: SH3KBP1 SH3-domain kinase binding protein 1".
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S (November 2000). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochemical and Biophysical Research Communications. 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. PMID 11071869.
  7. ↑ Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. PMC 306608. PMID 10921882.
  8. ↑ 8.0 8.1 Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O (December 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cellular Signalling. 12 (11–12): 769–79. doi:10.1016/S0898-6568(00)00129-7. PMID 11152963.
  9. ↑ 9.0 9.1 9.2 Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
  10. ↑ 10.0 10.1 10.2 10.3 Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095.
  11. ↑ 11.0 11.1 11.2 Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". The Journal of Biological Chemistry. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
  12. ↑ Kurakin AV, Wu S, Bredesen DE (September 2003). "Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening". The Journal of Biological Chemistry. 278 (36): 34102–9. doi:10.1074/jbc.M305264200. PMID 12829691.

Further reading

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