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==Historical perspective== | ==Historical perspective== | ||
* The first published illustration of a case of leukemia in medical text dates to 1827, when a French physician named [[Alfred-Armand-Louis-Marie Velpeau]] described a 63-year-old florist who developed an sickness denoted by [[fever]], [[weakness]], [[nephrolithiasis|urinary stones]], and substantial [[hepatosplenomegaly|enlargement of the liver and spleen]]. | * The first published illustration of a case of leukemia in medical text dates to 1827, when a French physician named [[Alfred-Armand-Louis-Marie Velpeau]] described a 63-year-old florist who developed an sickness denoted by [[fever]], [[weakness]], [[nephrolithiasis|urinary stones]], and substantial [[hepatosplenomegaly|enlargement of the liver and spleen]]. | ||
*Velpeau saw that the blood of this patient had a texture "like gruel", and thought that the blood appeared white due to the white corpuscles.<ref> | *Velpeau saw that the blood of this patient had a texture that was "like gruel", and thought that the blood appeared white due to the white corpuscles.<ref> | ||
{{cite book |last = Hoffman |first = Ronald ''et al.'' |title= Hematology: Basic Principles and Practice |year= 2005 |publisher= Elsevier Churchill Livingstone |location= St. Louis, Mo. |edition = 4th. ed. |pages = p. 1071 |id= ISBN 0-443-06629-9}}</ref> | {{cite book |last = Hoffman |first = Ronald ''et al.'' |title= Hematology: Basic Principles and Practice |year= 2005 |publisher= Elsevier Churchill Livingstone |location= St. Louis, Mo. |edition = 4th. ed. |pages = p. 1071 |id= ISBN 0-443-06629-9}}</ref> | ||
* In 1845, a | * In 1845, a number of patients who passed away with enlarged spleens and changes in the "colors and consistencies of their blood" was publicized by the Edinburgh-based [[pathologist]] J.H. Bennett; he used the term "leucocythemia" to outline this pathological condition.<ref>Bennett JH. Two cases of hypertrophy of the spleen and liver, where death took place from suppuration of blood. ''Edinburgh Med Surg J.'' (1845)64:413.</ref> | ||
* The term "leukemia" was coined by [[Rudolf Virchow]], the renowned German [[pathologist]], in 1856. As a pioneer in the use of the [[light microscope]] in pathology, Virchow was the first to describe the abnormal excess of white blood cells in patients with the clinical syndrome described by Velpeau and Bennett. As Virchow was uncertain of the [[etiology|cause]] of the white blood cell excess, he used the purely descriptive term "leukemia" (Greek: "white blood") to refer to the condition.<ref>Virchow R: Die Leukämie. In Virchow R (ed): Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Frankfurt, Meidinger, 1856, p 190.</ref> | * The term "leukemia" was coined by [[Rudolf Virchow]], the renowned German [[pathologist]], in 1856. As a pioneer in the use of the [[light microscope]] in pathology, Virchow was the first to describe the abnormal excess of white blood cells in patients with the clinical syndrome described by Velpeau and Bennett. As Virchow was uncertain of the [[etiology|cause]] of the white blood cell excess, he used the purely descriptive term "leukemia" (Greek: "white blood") to refer to the condition.<ref>Virchow R: Die Leukämie. In Virchow R (ed): Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Frankfurt, Meidinger, 1856, p 190.</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Carlos A Lopez, M.D. [2]
Overview
Leukemia was first described in 1827 by Alfred-Armand-Louis-Marie Velpeau, a french physician.
Historical perspective
- The first published illustration of a case of leukemia in medical text dates to 1827, when a French physician named Alfred-Armand-Louis-Marie Velpeau described a 63-year-old florist who developed an sickness denoted by fever, weakness, urinary stones, and substantial enlargement of the liver and spleen.
- Velpeau saw that the blood of this patient had a texture that was "like gruel", and thought that the blood appeared white due to the white corpuscles.[1]
- In 1845, a number of patients who passed away with enlarged spleens and changes in the "colors and consistencies of their blood" was publicized by the Edinburgh-based pathologist J.H. Bennett; he used the term "leucocythemia" to outline this pathological condition.[2]
- The term "leukemia" was coined by Rudolf Virchow, the renowned German pathologist, in 1856. As a pioneer in the use of the light microscope in pathology, Virchow was the first to describe the abnormal excess of white blood cells in patients with the clinical syndrome described by Velpeau and Bennett. As Virchow was uncertain of the cause of the white blood cell excess, he used the purely descriptive term "leukemia" (Greek: "white blood") to refer to the condition.[3]
- Wilhelm Ebstein introduced the term "acute leukemia" in 1889 to differentiate rapidly progressive and fatal leukemias from the more indolent chronic leukemias.[4]
- The technique of bone marrow examination to diagnose leukemia was first described in 1879 by Mosler.[5]
- Finally, in 1900 the lymphoblast, which is the malignant cell in acute lymphoid leukemia, was characterized by Naegeli, who divided the leukemias into myeloid and lymphocytic.[6][7]
References
- ↑ Hoffman, Ronald; et al. (2005). Hematology: Basic Principles and Practice (4th. ed. ed.). St. Louis, Mo.: Elsevier Churchill Livingstone. pp. p. 1071. ISBN 0-443-06629-9.
- ↑ Bennett JH. Two cases of hypertrophy of the spleen and liver, where death took place from suppuration of blood. Edinburgh Med Surg J. (1845)64:413.
- ↑ Virchow R: Die Leukämie. In Virchow R (ed): Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Frankfurt, Meidinger, 1856, p 190.
- ↑ Ebstein W. Ueber die acute Leukämie und Pseudoleukämie. Deutsch Arch Klin Med. (1889)44:343.
- ↑ Mosler F. Klinische Symptome und Therapie der medullären Leukämie. Berl Klin Wochenschr. (1876)13:702.
- ↑ Naegeli O. Über rothes Knochenmark und Myeloblasten. Deutsch Med Wochenschr. (1900) 26:287.
- ↑ Zhen-yi, Wang (2003). "Ham-Wasserman Lecture: Treatment of Acute Leukemia by Inducing Differentiation and Apoptosis". Hematology. PMID 14633774.