Neck masses differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Differentiating neck masses from other Diseases

Differential diagnosis of neck masses include:

Category	Diseases		Etiology	Benign	Malignant	Clinical manifestation									Paraclinical findings			Gold standard diagnosis	Associated findings
						Demography	History	Symptoms			Signs				Lab findings	Histopathology	Imaging
								Mass	Pain	Dysphagia	Mass exam	Skin changes	LAP	Others
Congenital	Branchial cleft cyst
	Thyroglossal duct cyst
	Hemangioma
	Vascular malformations
	Lymphatic malformations
	Laryngocele
	Ranula
	Teratoma
	Dermoid cyst
	Thymic cyst
Category	Diseases		Etiology	Benign	Malignant	Demography	History	Mass	Pain	Dysphagia	Mass exam	Skin changes	LAP	Others	Lab findings	Histopathology	Imaging	Gold standard diagnosis	Associated findings
Inflammatory	Reactive viral lymphadenopathy		CMV EBV
	HIV
	Bacterial lymphadenopathy	Tularemia
		Brucellosis
		Cat-scratch disease	Bartonella henselae infection
		Actinomycosis
		Mycobacterial infections
	Parasitic lymphadenopathy	Toxoplasma gondii
	Sarcoidosis
	Castleman disease
	Rosai-Dorfman disease
	Kawasaki disease
Category	Diseases		Etiology	Benign	Malignant	Demography	History	Mass	Pain	Dysphagia	Mass exam	Skin changes	LAP	Others	Lab findings	Histopathology	Imaging	Gold standard diagnosis	Associated findings
Neoplasm	Primary thyroid tumor
	Salivary gland neoplasm	Pleomorphic adenoma		+
		Warthin's tumor		+
		Lymphoepithelioma		+
		Oncocytoma
		Monomorphic adenoma
		Mucoepidermoid carcinoma
		Adenoid cystic carcinoma
		Adenocarcinoma
		Salivary duct carcinoma
		Squamous cell carcinoma
	Paraganglioma
	Schwannoma
	Lymphoma
	Lipoma
	Metastatic head and neck carcinoma
Category	Diseases		Etiology	Benign	Malignant	Demography	History	Mass	Pain	Dysphagia	Mass exam	Skin changes	LAP	Others	Lab findings	Histopathology	Imaging	Gold standard diagnosis	Associated findings