Hepatocellular adenoma risk factors: Difference between revisions
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{{CMG}};{{AE}} {{ZAS}} | {{CMG}};{{AE}} {{ZAS}} | ||
==Overview== | ==Overview== | ||
The most important risk factor in the development of | The most important [[risk factor]] in the development of [[hepatocellular adenoma]] is use of [[Oral contraceptive|oral contraceptive medications]]. Other [[Risk factor|risk factors]] include; [[Glycogen storage disease|glycogen storage diseases]], [[familial adenomatous polyposis]], [[klinefelter's syndrome]], [[metabolic syndrome]], [[obesity]], long term use of [[anabolic]] [[androgenic]] [[steroids]], [[vascular disorders]] such as [[portal vein]] [[agenesis]], [[Budd-Chiari syndrome|budd chiari syndrome]] and [[hereditary hemorrhagic telangiectasia]]. | ||
==Hepatocellular adenoma risk factors== | ==Hepatocellular adenoma risk factors== | ||
* The most important risk factor in the development of hepatocellular adenoma is use of oral contraceptive medications.<ref>{{Cite journal | * The most important [[risk factor]] in the development of [[hepatocellular adenoma]] is use of [[Oral contraceptive|oral contraceptive medications]].<ref>{{Cite journal | ||
| author = [[L. Rosenberg]] | | author = [[L. Rosenberg]] | ||
| title = The risk of liver neoplasia in relation to combined oral contraceptive use | | title = The risk of liver neoplasia in relation to combined oral contraceptive use | ||
| Line 22: | Line 22: | ||
:*[[Norgestrel and Ethinyl estradiol]] | :*[[Norgestrel and Ethinyl estradiol]] | ||
:* The risk is proportional to:<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188 }} </ref> | :* The risk is proportional to:<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188 }} </ref> | ||
::* Hormonal dose | ::* [[Hormone|Hormonal]] [[dose]] | ||
::* Duration of medication | ::* Duration of [[medication]] | ||
* Other risk factors include:<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188 }} </ref><ref>{{Cite journal | * Other [[Risk factor|risk factors]] include:<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188 }} </ref><ref>{{Cite journal | ||
| author = [[U. Beuers]], [[W. O. Richter]], [[M. M. Ritter]], [[B. Wiebecke]] & [[P. Schwandt]] | | author = [[U. Beuers]], [[W. O. Richter]], [[M. M. Ritter]], [[B. Wiebecke]] & [[P. Schwandt]] | ||
| title = Klinefelter's syndrome and liver adenoma | | title = Klinefelter's syndrome and liver adenoma | ||
| Line 56: | Line 56: | ||
}}</ref> | }}</ref> | ||
:* [[Clomiphene]] | :* [[Clomiphene]] | ||
:* | :* [[Methyltestosterone]] | ||
:* [[Danazol]] | :* [[Danazol]] | ||
:* [[Klinefelter's syndrome]] | :* [[Klinefelter's syndrome]] | ||
:* | :* [[Glycogen storage disease type I|Glycogen storage diseases I]], [[Glycogen storage disease type II|II]] and [[Glycogen storage disease type IV|IV]]. | ||
:* [[Familial adenomatous polyposis]] | :* [[Familial adenomatous polyposis]] | ||
==Risk factors for malignant transformation== | ==Risk factors for malignant transformation== | ||
The risk factor for malignant transformation of hepatic adenoma to hepatocellular carcinoma is:<ref name="pmid25786843">{{cite journal| author=Aamann L, Schultz N, Fallentin E, Hamilton-Dutoit S, Vogel I, Grønbæk H| title=[Hepatocellular adenoma - new classification and recommendations]. | journal=Ugeskr Laeger | year= 2015 | volume= 177 | issue= 12 | pages= | pmid=25786843 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25786843 }} </ref> | The [[risk factor]] for [[malignant transformation]] of [[Hepatocellular adenoma|hepatic adenoma]] to [[hepatocellular carcinoma]] is:<ref name="pmid25786843">{{cite journal| author=Aamann L, Schultz N, Fallentin E, Hamilton-Dutoit S, Vogel I, Grønbæk H| title=[Hepatocellular adenoma - new classification and recommendations]. | journal=Ugeskr Laeger | year= 2015 | volume= 177 | issue= 12 | pages= | pmid=25786843 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25786843 }} </ref> | ||
:* Gender (men) | :* Gender (men) | ||
:* Size (> 8 cm) | :* Size (> 8 cm) | ||
:* Subtype (''beta-catenin''-activated HCA) | :* Subtype (''[[beta-catenin]]''-activated [[Hepatocellular adenoma|HCA]]) | ||
==References== | ==References== | ||
Revision as of 14:37, 15 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]
Overview
The most important risk factor in the development of hepatocellular adenoma is use of oral contraceptive medications. Other risk factors include; glycogen storage diseases, familial adenomatous polyposis, klinefelter's syndrome, metabolic syndrome, obesity, long term use of anabolic androgenic steroids, vascular disorders such as portal vein agenesis, budd chiari syndrome and hereditary hemorrhagic telangiectasia.
Hepatocellular adenoma risk factors
- The most important risk factor in the development of hepatocellular adenoma is use of oral contraceptive medications.[1]
- Drospirenone and Ethinyl estradiol
- Norethindrone acetate and Ethinyl estradiol
- Norgestimate and Ethinyl estradiol
- Norgestrel and Ethinyl estradiol
- The risk is proportional to:[2]
- Hormonal dose
- Duration of medication
- Other risk factors include:[2][3][4][5]
Risk factors for malignant transformation
The risk factor for malignant transformation of hepatic adenoma to hepatocellular carcinoma is:[6]
- Gender (men)
- Size (> 8 cm)
- Subtype (beta-catenin-activated HCA)
References
- ↑ L. Rosenberg (1991). "The risk of liver neoplasia in relation to combined oral contraceptive use". Contraception. 43 (6): 643–652. PMID 1651205. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
- ↑ U. Beuers, W. O. Richter, M. M. Ritter, B. Wiebecke & P. Schwandt (1991). "Klinefelter's syndrome and liver adenoma". Journal of clinical gastroenterology. 13 (2): 214–216. PMID 1851773. Unknown parameter
|month=ignored (help) - ↑ N. S. Alshak, J. Cocjin, L. Podesta, R. van de Velde, L. Makowka, P. Rosenthal & S. A. Geller (1994). "Hepatocellular adenoma in glycogen storage disease type IV". Archives of pathology & laboratory medicine. 118 (1): 88–91. PMID 8285839. Unknown parameter
|month=ignored (help) - ↑ S. Bala, P. H. Wunsch & W. G. Ballhausen (1997). "Childhood hepatocellular adenoma in familial adenomatous polyposis: mutations in adenomatous polyposis coli gene and p53". Gastroenterology. 112 (3): 919–922. PMID 9041254. Unknown parameter
|month=ignored (help) - ↑ Aamann L, Schultz N, Fallentin E, Hamilton-Dutoit S, Vogel I, Grønbæk H (2015). "[Hepatocellular adenoma - new classification and recommendations]". Ugeskr Laeger. 177 (12). PMID 25786843.