Merkel cell cancer risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
Risk factors for the development of | Risk factors for the development of [[merkel cell cancer]] include old age, male gender, caucasian race, chronic exposure to [[sunlight]], [[immunodeficiency]], and personal history of [[cancer]]. | ||
==Risk Factors== | ==Risk Factors== | ||
Common risk factors for the development of | |||
* | === Common Risk Factors === | ||
* | * Common risk factors in the development of [[merkel cell cancer]] may be occupational, environmental, genetic, and viral. | ||
*Chronic exposure to sunlight | |||
*[[Immunodeficiency]] or administration of [[Immunosuppressive therapy|immunosuppressive]] pharmacologic agents | * Common risk factors for the development of [[merkel cell cancer]] include:<ref name="pmid18280333">{{cite journal| author=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF et al.| title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. | journal=J Am Acad Dermatol | year= 2008 | volume= 58 | issue= 3 | pages= 375-81 | pmid=18280333 | doi=10.1016/j.jaad.2007.11.020 | pmc=PMC2335370 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18280333 }} </ref> | ||
*Personal history of cancers | ** [[Mutations]] in the [[DNA]] due to polyomaviruses | ||
** Chronic exposure to [[sunlight]] | |||
** [[Immunodeficiency]] or administration of [[Immunosuppressive therapy|immunosuppressive]] pharmacologic agents | |||
=== Less Common Risk Factors === | |||
* Less common risk factors in the development of [[merkel cell cancer]] include:<ref name="pmid29102486">{{cite journal |vauthors=Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P |title=Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics |journal=J. Am. Acad. Dermatol. |volume=78 |issue=3 |pages=457–463.e2 |date=March 2018 |pmid=29102486 |doi=10.1016/j.jaad.2017.10.028 |url=}}</ref> | |||
** Old [[age]] > 50 years | |||
** Male gender | |||
** Fair skin | |||
** Personal history of [[cancers]] | |||
** Caucasian race | |||
==References== | ==References== | ||
Revision as of 15:57, 15 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Risk factors for the development of merkel cell cancer include old age, male gender, caucasian race, chronic exposure to sunlight, immunodeficiency, and personal history of cancer.
Risk Factors
Common Risk Factors
- Common risk factors in the development of merkel cell cancer may be occupational, environmental, genetic, and viral.
- Common risk factors for the development of merkel cell cancer include:[1]
- Mutations in the DNA due to polyomaviruses
- Chronic exposure to sunlight
- Immunodeficiency or administration of immunosuppressive pharmacologic agents
Less Common Risk Factors
- Less common risk factors in the development of merkel cell cancer include:[2]
References
- ↑ Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF; et al. (2008). "Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features". J Am Acad Dermatol. 58 (3): 375–81. doi:10.1016/j.jaad.2007.11.020. PMC 2335370. PMID 18280333.
- ↑ Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P (March 2018). "Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics". J. Am. Acad. Dermatol. 78 (3): 457–463.e2. doi:10.1016/j.jaad.2017.10.028. PMID 29102486.