Mucoepidermoid carcinoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
Mucoepidermoid carcinoma may be classified according to location into 2 subtypes: salivary gland-confined carcinomas and other organ mucoepidermoid carcinomas. | Mucoepidermoid carcinoma may be classified according to location into 2 subtypes: salivary gland-confined carcinomas and other organ mucoepidermoid carcinomas. Based on histological features, it is divided into low, intermediate and high grade tumors. | ||
==Classification== | ==Classification== | ||
Mucoepidermoid carcinoma may be classified according to location into 2 subtypes:<ref name="radiowiki">Mucoepidermoid carcinoma. Radiopedia. Dr Frank Gailliard. http://radiopaedia.org/articles/mucoepidermoid-carcinoma-of-salivary-glands Accessed on February 17, 2016 </ref> | Mucoepidermoid carcinoma may be classified according to location into 2 subtypes:<ref name="radiowiki">Mucoepidermoid carcinoma. Radiopedia. Dr Frank Gailliard. http://radiopaedia.org/articles/mucoepidermoid-carcinoma-of-salivary-glands Accessed on February 17, 2016 </ref> | ||
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===Grading based on Histopathology:=== | ===Grading based on Histopathology:=== | ||
* Mucoepidermoid carcinoma are graded into three | * Mucoepidermoid carcinoma are graded into three sub types based on [[histopathological]] features: | ||
** Low | ** Low | ||
** Intermediate | ** Intermediate | ||
** High grade | ** High grade | ||
* The three most popular grading systems are: | * The three most popular grading systems are: | ||
** | ** The AFIP grading system <ref name="pmid9529011">{{cite journal |vauthors=Goode RK, Auclair PL, Ellis GL |title=Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria |journal=Cancer |volume=82 |issue=7 |pages=1217–24 |date=April 1998 |pmid=9529011 |doi= |url=}}</ref> | ||
** | ** Modified Healey system<ref name="pmid2221741">{{cite journal |vauthors=Batsakis JG, Luna MA |title=Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas |journal=Ann. Otol. Rhinol. Laryngol. |volume=99 |issue=10 Pt 1 |pages=835–8 |date=October 1990 |pmid=2221741 |doi=10.1177/000348949009901015 |url=}}</ref> | ||
** The Brandwein<ref name="pmid12484654">{{cite journal |vauthors=Brandwein MS, Ferlito A, Bradley PJ, Hille JJ, Rinaldo A |title=Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes |journal=Acta Otolaryngol. |volume=122 |issue=7 |pages=758–64 |date=October 2002 |pmid=12484654 |doi= |url=}}</ref> | ** The Brandwein system<ref name="pmid12484654">{{cite journal |vauthors=Brandwein MS, Ferlito A, Bradley PJ, Hille JJ, Rinaldo A |title=Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes |journal=Acta Otolaryngol. |volume=122 |issue=7 |pages=758–64 |date=October 2002 |pmid=12484654 |doi= |url=}}</ref> | ||
* All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion. | * All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion. | ||
* | * | ||
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* Macrocysts, microcysts, | * Macrocysts, microcysts, | ||
* Transition with excretory ducts, | * Transition with [[excretory]] [[ducts]], | ||
* Differentiated | * Differentiated [[mucin]] producing epidermoid cells, often in a 1:1 ratio, minimal to moderate intermediate [[cell]] population | ||
* Daughter cyst proliferation from large cysts | * Daughter [[cyst]] proliferation from large [[Cyst|cysts]] | ||
* Minimal to absent pleomorphism, rare mitoses | * Minimal to absent [[Pleomorphism|pleomorphism,]] rare [[mitoses]] | ||
* Broad-front, often circumscribed invasion | * Broad-front, often circumscribed invasion | ||
* Pools of extravasated mucin with stromal reaction | * Pools of extravasated [[mucin]] with [[stromal]] reaction | ||
|- | |- | ||
|Intermediated grade | |Intermediated grade | ||
| | | | ||
* No macrocysts, few microcysts | * No macrocysts, few microcysts | ||
* Solid nests of cells | * Solid nests of [[cells]] | ||
* Large duct not conspicuous | * Large [[duct]], but not conspicuous | ||
* Slight to moderate pleomorphism, few mitoses, prominent nuclei and nucleoli | * Slight to moderate [[pleomorphism]], few [[mitoses]], prominent [[nuclei]] and [[nucleoli]] | ||
* Invasive quality, usually well defined and uncircumscribed | * Invasive quality, usually well defined and uncircumscribed | ||
* Chronic inflammation at periphery | * Chronic [[inflammation]] at periphery | ||
* Fibrosis separates nests of cells and groups of nests | * [[Fibrosis]] separates nests of [[cells]] and groups of nests | ||
|- | |- | ||
|High grade | |High grade | ||
| | | | ||
* No macrocysts | * No macrocysts | ||
* Predominantly solid but may be nearly all glandular | * Predominantly solid but may be nearly all glandular | ||
* Cell constituents range from poorly differentiated to recognizable epidermoid and intermediate to ductal type adenocarcinoma | * Cell constituents range from poorly differentiated to recognizable epidermoid and intermediate to [[Ductal carcinoma|ductal]] type [[adenocarcinoma]] | ||
* Considerable pleomorphism, mitoses | * Considerable [[pleomorphism]], [[mitoses]] | ||
* Unquestionable soft tissue, perineural and intravascular invasion | * Unquestionable soft tissue, perineural and [[intravascular]] invasion | ||
* Chronic inflammation less prominent, desmoplasia of stroma may outline invasive clusters | * Chronic [[inflammation]] less prominent, [[desmoplasia]] of [[stroma]] may outline [[invasive]] clusters | ||
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Latest revision as of 15:38, 16 January 2019
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Mucoepidermoid carcinoma Microchapters |
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Differentiating Mucoepidermoid Carcinoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Mucoepidermoid carcinoma classification On the Web |
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American Roentgen Ray Society Images of Mucoepidermoid carcinoma classification |
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Risk calculators and risk factors for Mucoepidermoid carcinoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Badria Munir M.B.B.S.[2] Maria Fernanda Villarreal, M.D. [3]
Overview
Mucoepidermoid carcinoma may be classified according to location into 2 subtypes: salivary gland-confined carcinomas and other organ mucoepidermoid carcinomas. Based on histological features, it is divided into low, intermediate and high grade tumors.
Classification
Mucoepidermoid carcinoma may be classified according to location into 2 subtypes:[1]
| Classification: Mucoepidermoid Carcinomas | ||
|---|---|---|
| Salivary gland-confined carcinomas |
|
|
|
| |
| Other organ mucoepidermoid carcinomas |
| |
Grading based on Histopathology:
- Mucoepidermoid carcinoma are graded into three sub types based on histopathological features:
- Low
- Intermediate
- High grade
- The three most popular grading systems are:
- All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion.
| Category | Histopathologic findings |
|---|---|
| Low grade |
|
| Intermediated grade |
|
| High grade |
|
References
- ↑ Mucoepidermoid carcinoma. Radiopedia. Dr Frank Gailliard. http://radiopaedia.org/articles/mucoepidermoid-carcinoma-of-salivary-glands Accessed on February 17, 2016
- ↑ Goode RK, Auclair PL, Ellis GL (April 1998). "Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria". Cancer. 82 (7): 1217–24. PMID 9529011.
- ↑ Batsakis JG, Luna MA (October 1990). "Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas". Ann. Otol. Rhinol. Laryngol. 99 (10 Pt 1): 835–8. doi:10.1177/000348949009901015. PMID 2221741.
- ↑ Brandwein MS, Ferlito A, Bradley PJ, Hille JJ, Rinaldo A (October 2002). "Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes". Acta Otolaryngol. 122 (7): 758–64. PMID 12484654.