Astrocytoma differential diagnosis: Difference between revisions

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|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
! colspan="2" rowspan="4" |Diseases
! colspan="2" rowspan="4" |Diseases
| colspan="8" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Clinical manifestations'''
| colspan="7" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Clinical manifestations'''
! colspan="4" rowspan="2" |Para-clinical findings
! colspan="4" rowspan="2" |Para-clinical findings
| colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Gold standard'''
| colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Gold standard'''
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|-
|-
| colspan="5" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Symptoms'''
| colspan="5" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Symptoms'''
! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical examination
! colspan="2" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical examination
|-
|-
!style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunohistopathology
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunohistopathology
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! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Constitutional
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Constitutional
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Extraocular movement disorder
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Extraocular movement disorder
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hydrocephalus
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Focal neurologic deficit
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Focal neurologic deficit
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Endocrine abnormalities
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Endocrine abnormalities
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* Cross corpus callosum (butterfly glioma)
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* Astrocyte origin
* Astrocyte origin
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* Chicken wire capillary pattern
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* Oligodendrocyte origin
* Oligodendrocyte origin
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* Dural attachement
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* Arachnoid origin
* Arachnoid origin
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* Might secret [[erythropoietin]] and cause [[polycythemia]]
* Might secret [[erythropoietin]] and cause [[polycythemia]]
* Can be associated with von hippel-lindau syndrome
|-
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |Pitutary adenoma
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Pitutary adenoma
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* Single mass with ring enhancement
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* B cell origin
* B cell origin
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* Hydrocephalus
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* Neuroectoderm origin
* Neuroectoderm origin
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* Hydrocephalus
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* Ependymal cell origin
* Ependymal cell origin
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| style="background: #F5F5F5; padding: 5px;" | + vertical gaze palsy
| style="background: #F5F5F5; padding: 5px;" | + vertical gaze palsy
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |AV malformation
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* Multifocal masses with ring enhancement
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* Multifocal
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Revision as of 16:41, 17 January 2019

Astrocytoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.

Overview

Differentiating astrocytoma from other Diseases

Diseases Clinical manifestations Para-clinical findings Gold standard Additional findings
Symptoms Physical examination
Lab Findings Imaging Immunohistopathology
Headache Seizure Visual disturbance Hearing loss Constitutional Extraocular movement disorder Focal neurologic deficit Endocrine abnormalities CT scan MRI
Adult primary brain tumors Glioblastoma multiform + ± − + −
  • Cross corpus callosum (butterfly glioma)
  • Astrocyte origin
  • Pleomorphic cell
  • Pseudopalisading appearance
  • GFAP +
  • Necrosis +
  • Hemorrhage +
  • Vascular prolifration +
  • Biopsy
Oligodendroglioma + ± − + −
  • Chicken wire capillary pattern
  • Oligodendrocyte origin
  • Calcification +
  • Fried egg cell appearance
  • Biopsy
Meningioma + ± − + −
  • Dural attachement
  • Arachnoid origin
  • Psammoma bodies
  • Whorled spindle cell pattern
  • Biopsy
Hemangioblastoma + ± − + −
  • Blood vessel origin
  • Capillaries with thin walls
  • Biopsy
Pitutary adenoma − − + Bitemporal hemianopia − −
  • + Functional adenomas or pressure effect of non-functional adenomas
  • Endocrine cell hyperplasia
  • History/physical examination and clinical findings
Schwannoma − − + − −
  • Schwann cell origin
  • S100+
  • Biopsy
primary CNS lymphoma + ± − −
  • Single mass with ring enhancement
  • B cell origin
  • Similar to non hodgkin lymphoma (diffuse large B cell)
  • Biopsy
Childhood primary brain tumors Pilocytic astrocytoma + ± − −
  • Glial cell origin
  • Solid and cystic component
  • GFAP +
  • Biopsy
Medulloblastoma + ± − −
  • Hydrocephalus
  • Neuroectoderm origin
  • Homer wright rosettes
  • Biopsy
Ependymoma + ± − −
  • Hydrocephalus
  • Ependymal cell origin
  • Perivascular pseudorosette
  • Biopsy
Craniopharyngioma + ± + Bitemporal hemianopia −
  • + Pressure effect on pituitary gland
  • Ectodermal origin (Rathkes pouch)
  • Calcification +
  • Biopsy
Pinealoma + ± − + vertical gaze palsy +
  • + B-hCG rise leads to precocious puberty in males
  • Similar to testicular seminoma
  • Biopsy
Vascular AV malformation + + −
Brain aneurysm + −
Infectious Bacterial brain abscess + +
Tuberculosis + +
Toxoplasmosis +
  • Multifocal masses with ring enhancement
Hydatid cyst +
Fungal +
Other Brain metastasis +
  • Multifocal

References

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