Merkel cell cancer laboratory tests: Difference between revisions
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** Epithelial membrane [[antigen]], and | ** Epithelial membrane [[antigen]], and | ||
** Ber-EP4 | ** Ber-EP4 | ||
* [[Merkel cell carcinoma]] may also shows positive for [[neuroendocrine]] markers such as: | * [[Merkel cell carcinoma]] may also shows positive for [[neuroendocrine]] markers such as:<ref name="pmid25765179">{{cite journal |vauthors=Gardair C, Samimi M, Touzé A, Coursaget P, Lorette G, Caille A, Wierzbicka E, Croué A, Avenel-Audran M, Aubin F, Kerdraon R, Estève E, Beneton N, Guyétant S |title=Somatostatin Receptors 2A and 5 Are Expressed in Merkel Cell Carcinoma with No Association with Disease Severity |journal=Neuroendocrinology |volume=101 |issue=3 |pages=223–35 |date=2015 |pmid=25765179 |doi=10.1159/000381062 |url=}}</ref> | ||
** [[Chromogranin]] | ** [[Chromogranin]] | ||
** [[Synaptophysin]] | ** [[Synaptophysin]] | ||
** [[Calcitonin]] and | ** [[Calcitonin]] and | ||
** [[Vasoactive intestinal peptide]] | ** [[Vasoactive intestinal peptide]] | ||
** [[Somatostatin]] receptors (SSTRs) | |||
'''Cytogenetic and molecular analysis''' | '''Cytogenetic and molecular analysis''' | ||
Revision as of 00:44, 19 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Laboratory findings consistent with the diagnosis of merkel cell cancer include immunohistochemistry, cytogenetic and molecular analysis, and [abnormal test 3]. .
Laboratory findings
Laboratory findings consistent with the diagnosis of merkel cell cancer include:
Immunohistochemistry
- Epithelial markers play an important role in the diagnosis of merkel cell cancer which include:[1]
- Cytokeratin AE1/AE3
- CAM 5.2
- Pan-cytokeratin
- Epithelial membrane antigen, and
- Ber-EP4
- Merkel cell carcinoma may also shows positive for neuroendocrine markers such as:[2]
- Chromogranin
- Synaptophysin
- Calcitonin and
- Vasoactive intestinal peptide
- Somatostatin receptors (SSTRs)
Cytogenetic and molecular analysis
References
- ↑ Weinbreck N, Marie B, Bressenot A, Montagne K, Joud A, Baumann C, Klein O, Vignaud JM (July 2008). "Immunohistochemical markers to distinguish between hemangioblastoma and metastatic clear-cell renal cell carcinoma in the brain: utility of aquaporin1 combined with cytokeratin AE1/AE3 immunostaining". Am. J. Surg. Pathol. 32 (7): 1051–9. doi:10.1097/PAS.0b013e3181609d7d. PMID 18496143.
- ↑ Gardair C, Samimi M, Touzé A, Coursaget P, Lorette G, Caille A, Wierzbicka E, Croué A, Avenel-Audran M, Aubin F, Kerdraon R, Estève E, Beneton N, Guyétant S (2015). "Somatostatin Receptors 2A and 5 Are Expressed in Merkel Cell Carcinoma with No Association with Disease Severity". Neuroendocrinology. 101 (3): 223–35. doi:10.1159/000381062. PMID 25765179.