Merkel cell cancer laboratory tests: Difference between revisions
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** [[Somatostatin]] receptors (SSTRs) | ** [[Somatostatin]] receptors (SSTRs) | ||
'''Cytogenetic and molecular analysis''' | '''Cytogenetic and molecular analysis''' | ||
* Many chromosomal abnormalities have been detected in merkel cell cancer but most commonly affected are: | * Many chromosomal abnormalities have been detected in merkel cell cancer but most commonly affected are:<ref name="pmid3422041">{{cite journal |vauthors=Sozzi G, Bertoglio MG, Pilotti S, Rilke F, Pierotti MA, Della Porta G |title=Cytogenetic studies in primary and metastatic neuroendocrine Merkel cell carcinoma |journal=Cancer Genet. Cytogenet. |volume=30 |issue=1 |pages=151–8 |date=January 1988 |pmid=3422041 |doi= |url=}}</ref> | ||
** [[Chromosome]] 1 | ** [[Chromosome]] 1: Especially involving p and q arms | ||
** [[Chromosome]] 5 | ** [[Chromosome]] 5 | ||
** [[Chromosome]] 6 | ** [[Chromosome]] 6 |
Revision as of 17:14, 21 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Laboratory findings consistent with the diagnosis of merkel cell cancer include immunohistochemistry, cytogenetic and molecular analysis, and [abnormal test 3]. .
Laboratory findings
Laboratory findings consistent with the diagnosis of merkel cell cancer include:
Immunohistochemistry
- Epithelial markers play an important role in the diagnosis of merkel cell cancer which include:[1]
- Cytokeratin AE1/AE3
- CAM 5.2
- Pan-cytokeratin
- Epithelial membrane antigen, and
- Ber-EP4
- Merkel cell carcinoma may also shows positive for neuroendocrine markers such as:[2]
- Chromogranin
- Synaptophysin
- Calcitonin and
- Vasoactive intestinal peptide
- Somatostatin receptors (SSTRs)
Cytogenetic and molecular analysis
- Many chromosomal abnormalities have been detected in merkel cell cancer but most commonly affected are:[3]
- Chromosome 1: Especially involving p and q arms
- Chromosome 5
- Chromosome 6
- Chromosome 8, and
- Chromosome 13
References
- ↑ Weinbreck N, Marie B, Bressenot A, Montagne K, Joud A, Baumann C, Klein O, Vignaud JM (July 2008). "Immunohistochemical markers to distinguish between hemangioblastoma and metastatic clear-cell renal cell carcinoma in the brain: utility of aquaporin1 combined with cytokeratin AE1/AE3 immunostaining". Am. J. Surg. Pathol. 32 (7): 1051–9. doi:10.1097/PAS.0b013e3181609d7d. PMID 18496143.
- ↑ Gardair C, Samimi M, Touzé A, Coursaget P, Lorette G, Caille A, Wierzbicka E, Croué A, Avenel-Audran M, Aubin F, Kerdraon R, Estève E, Beneton N, Guyétant S (2015). "Somatostatin Receptors 2A and 5 Are Expressed in Merkel Cell Carcinoma with No Association with Disease Severity". Neuroendocrinology. 101 (3): 223–35. doi:10.1159/000381062. PMID 25765179.
- ↑ Sozzi G, Bertoglio MG, Pilotti S, Rilke F, Pierotti MA, Della Porta G (January 1988). "Cytogenetic studies in primary and metastatic neuroendocrine Merkel cell carcinoma". Cancer Genet. Cytogenet. 30 (1): 151–8. PMID 3422041.