Sandbox:Hannan1: Difference between revisions
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Hannan Javed (talk | contribs) No edit summary |
Hannan Javed (talk | contribs) No edit summary |
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! colspan="2" rowspan="2" |Neuroendocrine tumor | ! colspan="2" rowspan="2" |Neuroendocrine tumor | ||
! colspan="2" |Clinical manifestations | ! colspan="2" |Clinical manifestations | ||
! colspan=" | ! colspan="6" |Dianosis | ||
! | ! rowspan="2" |Gold | ||
standard | |||
! rowspan="2" |Other features | ! rowspan="2" |Other features | ||
|- | |- | ||
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!<small>Immunohistochemistry</small> | !<small>Immunohistochemistry</small> | ||
!<small>Imaging</small> | !<small>Imaging</small> | ||
!<small> | !<small>Others</small> | ||
|- | |- | ||
| colspan="2" |Medullary thyroid carcinoma | | colspan="2" |Medullary thyroid carcinoma | ||
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* Diarrhea | * Diarrhea | ||
* Weight loss | * Weight loss | ||
| | | | ||
* Palpable neck | * Palpable neck | ||
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|Nests of uniform cells | |Nests of uniform cells | ||
Deposition of stromal amyloid | Deposition of stromal | ||
amyloid | |||
Granular chromatin | Granular chromatin | ||
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|Solid thyroid nodule (US) | |Solid thyroid nodule (US) | ||
CT scan/MRI | CT scan/MRI and PET scan for metastatis | ||
|Genetic testing | |||
|FNA cytology with immunohisto- | |||
| | chemistry and | ||
calcitonin levels | |||
|Associated with MEN 2A and 2B | |||
Familial association with RET mutations | |||
May present as Cushing syndrome | |||
|- | |- | ||
| colspan="2" |Pheochromocytoma | | colspan="2" |Pheochromocytoma | ||
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| colspan="2" |Merkel cell carcinoma | | colspan="2" |Merkel cell carcinoma | ||
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| colspan="2" |Parathyroid adenoma | | colspan="2" |Parathyroid adenoma | ||
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| colspan="2" |Paraganglioma | | colspan="2" |Paraganglioma | ||
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| colspan="2" |Pituitary gland tumors | | colspan="2" |Pituitary gland tumors | ||
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| colspan="2" |Neuroendocrine tumors of the ovaries or testicles | | colspan="2" |Neuroendocrine tumors of the ovaries or testicles | ||
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| colspan="2" |Thymic neuroendocrine cancer | | colspan="2" |Thymic neuroendocrine cancer | ||
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| rowspan="4" |Lung neuroendocrine tumors | | rowspan="4" |Lung neuroendocrine tumors | ||
|Typical carcinoid tumours | |Typical carcinoid tumours | ||
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|- | |- | ||
|Atypical carcinoid tumours | |Atypical carcinoid tumours | ||
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|- | |- | ||
|Large cell lung neuroendocrine carcinomas | |Large cell lung neuroendocrine carcinomas | ||
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|Small cell lung neuroendocrine carcinomas | |Small cell lung neuroendocrine carcinomas | ||
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| rowspan="6" |Pancreatic neuroendocrine tumours | | rowspan="6" |Pancreatic neuroendocrine tumours | ||
|Gastrinoma | |Gastrinoma | ||
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|- | |- | ||
|Insulinoma | |Insulinoma | ||
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|- | |- | ||
|Glucagonoma | |Glucagonoma | ||
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|- | |- | ||
|Somatostatinoma | |Somatostatinoma | ||
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|- | |- | ||
|VIPoma | |VIPoma | ||
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|- | |- | ||
|ACTHoma | |ACTHoma | ||
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| rowspan="4" |Gastric neuroendocrine tumors | | rowspan="4" |Gastric neuroendocrine tumors | ||
|Type I GNET | |Type I GNET | ||
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|Type II GNET | |Type II GNET | ||
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|- | |- | ||
|Type III GNET | |Type III GNET | ||
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|- | |- | ||
|Type IV GNET | |Type IV GNET | ||
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| rowspan="5" |Duodenal neuroendocrine tumors | | rowspan="5" |Duodenal neuroendocrine tumors | ||
|Gastrinomas | |Gastrinomas | ||
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|Somatostatinomas | |Somatostatinomas | ||
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|Gangliocytic paraganglionomas | |Gangliocytic paraganglionomas | ||
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|Nonfunctioning NET | |Nonfunctioning NET | ||
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|neuroendocrine carcinomas | |neuroendocrine carcinomas | ||
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|Jejuno-Ileal neuroendocrine tumors | |Jejuno-Ileal neuroendocrine tumors | ||
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|Appendix neuroendocrine tumors | |Appendix neuroendocrine tumors | ||
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|Colon neuroendocrine tumors | |Colon neuroendocrine tumors | ||
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|Rectum neuroendocrine tumors | |Rectum neuroendocrine tumors | ||
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Revision as of 15:06, 22 January 2019
| Neuroendocrine tumor | Clinical manifestations | Dianosis | Gold
standard |
Other features | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptoms | Signs | Blood | Gross | Histology | Immunohistochemistry | Imaging | Others | ||||
| Medullary thyroid carcinoma |
|
mass
syndrome |
↑ Calcitonin
↑ Serum calcium ↑ or - Cortisol ↑ CEA level |
White or gray in color
Firm to palpation |
Nests of uniform cells
Deposition of stromal amyloid Granular chromatin C-cell hyperplasia |
Calcitonin
Chromogranin A Carcinoembryonic antigen (CEA) |
Solid thyroid nodule (US)
CT scan/MRI and PET scan for metastatis |
Genetic testing | FNA cytology with immunohisto-
chemistry and calcitonin levels |
Associated with MEN 2A and 2B
Familial association with RET mutations May present as Cushing syndrome | |
| Pheochromocytoma | |||||||||||
| Merkel cell carcinoma | |||||||||||
| Parathyroid adenoma | |||||||||||
| Paraganglioma | |||||||||||
| Pituitary gland tumors | |||||||||||
| Neuroendocrine tumors of the ovaries or testicles | |||||||||||
| Thymic neuroendocrine cancer | |||||||||||
| Lung neuroendocrine tumors | Typical carcinoid tumours | ||||||||||
| Atypical carcinoid tumours | |||||||||||
| Large cell lung neuroendocrine carcinomas | |||||||||||
| Small cell lung neuroendocrine carcinomas | |||||||||||
| Pancreatic neuroendocrine tumours | Gastrinoma | ||||||||||
| Insulinoma | |||||||||||
| Glucagonoma | |||||||||||
| Somatostatinoma | |||||||||||
| VIPoma | |||||||||||
| ACTHoma | |||||||||||
| Gastric neuroendocrine tumors | Type I GNET | ||||||||||
| Type II GNET | |||||||||||
| Type III GNET | |||||||||||
| Type IV GNET | |||||||||||
| Duodenal neuroendocrine tumors | Gastrinomas | ||||||||||
| Somatostatinomas | |||||||||||
| Gangliocytic paraganglionomas | |||||||||||
| Nonfunctioning NET | |||||||||||
| neuroendocrine carcinomas | |||||||||||
| Jejuno-Ileal neuroendocrine tumors | |||||||||||
| Appendix neuroendocrine tumors | |||||||||||
| Colon neuroendocrine tumors | |||||||||||
| Rectum neuroendocrine tumors | |||||||||||