| '''Condensin-2 complex subunit G2''' (CAP-G2) also known as '''chromosome-associated protein G2''' (CAP-G2) or '''leucine zipper protein 5''' (LUZP5) is a [[protein]] that in humans is encoded by the ''NCAPG2'' [[gene]].<ref name="pmid14532007">{{cite journal | vauthors = Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T | title = Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells | journal = Cell | volume = 115 | issue = 1 | pages = 109–21 | date = October 2003 | pmid = 14532007 | pmc = | doi = 10.1016/S0092-8674(03)00724-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54892| access-date = }}</ref> CAP-G2 is a subunit of [[condensin]] II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis<ref>{{cite journal | vauthors = Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT | title = The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores | journal = Nature Communications | volume = 5 | pages = 4588 | date = August 2014 | pmid = 25109385 | doi = 10.1038/ncomms5588 }}</ref> | | '''Condensin-2 complex subunit G2''' (CAP-G2) also known as '''chromosome-associated protein G2''' (CAP-G2) or '''leucine zipper protein 5''' (LUZP5) is a [[protein]] that in humans is encoded by the ''NCAPG2'' [[gene]].<ref name="pmid14532007">{{cite journal | vauthors = Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T | title = Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells | journal = Cell | volume = 115 | issue = 1 | pages = 109–21 | date = October 2003 | pmid = 14532007 | pmc = | doi = 10.1016/S0092-8674(03)00724-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54892| access-date = }}</ref> CAP-G2 is a subunit of [[condensin]] II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis<ref>{{cite journal | vauthors = Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT | title = The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores | journal = Nature Communications | volume = 5 | pages = 4588 | date = August 2014 | pmid = 25109385 | doi = 10.1038/ncomms5588 }}</ref> |
| | Mutations in this gene in humans have been associated with severe neurodevelopmental defects, [[failure to thrive]], ocular abnormalities, and defects in urogenital and limb morphogenesis.<ref name=Khan2019>{{cite journal | vauthors = Khan TN, Khan K, Sadeghpour A, Reynolds H, Perilla Y, McDonald MT, Gallentine WB, Baig SM, Davis EE, Katsanis N | collaboration = Task Force for Neonatal Genomics | title = Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies | journal = American Journal of Human Genetics | volume = 104 | issue = 1 | pages = 94–111 | date = January 2019 | pmid = 30609410 | doi = 10.1016/j.ajhg.2018.11.017 }}</ref> |
