Pleomorphic adenoma causes: Difference between revisions
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{{CMG}}; {{AE}} | {{CMG}}; {{AE}} | ||
==Overview== | ==Overview== | ||
There are no well established causes for pleomorphic adenoma. However some clonal [[chromosomal abnormalities]] with aberrations involving 8q12 and 12q15 have been described. Simian virus(SV40) is thought to play a role either in the onset or progression of the tumor. | There are no well established [[causes]] for pleomorphic adenoma. However some clonal [[chromosomal abnormalities]] with aberrations involving 8q12 and 12q15 have been described. [[Simian virus 40|Simian virus]](SV40) is thought to play a role either in the onset or progression of the [[tumor]]. | ||
==Causes== | ==Causes== | ||
*There are no established causes for the development of pleomorphic adenoma. | *There are no established [[causes]] for the [[development]] of pleomorphic adenoma. | ||
*However some clonal [[chromosomal abnormalities]] with aberrations involving 8q12 and 12q15 have been described.<ref name="pmid22190789">{{cite journal |vauthors=Debnath SC, Adhyapok AK |title=Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip |journal=J Maxillofac Oral Surg |volume=9 |issue=2 |pages=205–8 |date=June 2010 |pmid=22190789 |doi=10.1007/s12663-010-0052-5 |url=}}</ref> | *However some clonal [[chromosomal abnormalities]] with aberrations involving 8q12 and 12q15 have been described.<ref name="pmid22190789">{{cite journal |vauthors=Debnath SC, Adhyapok AK |title=Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip |journal=J Maxillofac Oral Surg |volume=9 |issue=2 |pages=205–8 |date=June 2010 |pmid=22190789 |doi=10.1007/s12663-010-0052-5 |url=}}</ref> | ||
*[[Oncogenic]] [[Simian virus 40|simian virus]](SV40) may play a role in the onset or progression of pleomorphic adenoma.<ref name="pmid12368186">{{cite journal |vauthors=Martinelli M, Martini F, Rinaldi E, Caramanico L, Magri E, Grandi E, Carinci F, Pastore A, Tognon M |title=Simian virus 40 sequences and expression of the viral large T antigen oncoprotein in human pleomorphic adenomas of parotid glands |journal=Am. J. Pathol. |volume=161 |issue=4 |pages=1127–33 |date=October 2002 |pmid=12368186 |pmc=1867276 |doi=10.1016/S0002-9440(10)64389-1 |url=}}</ref> | *[[Oncogenic]] [[Simian virus 40|simian virus]](SV40) may play a role in the onset or progression of pleomorphic adenoma.<ref name="pmid12368186">{{cite journal |vauthors=Martinelli M, Martini F, Rinaldi E, Caramanico L, Magri E, Grandi E, Carinci F, Pastore A, Tognon M |title=Simian virus 40 sequences and expression of the viral large T antigen oncoprotein in human pleomorphic adenomas of parotid glands |journal=Am. J. Pathol. |volume=161 |issue=4 |pages=1127–33 |date=October 2002 |pmid=12368186 |pmc=1867276 |doi=10.1016/S0002-9440(10)64389-1 |url=}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There are no well established causes for pleomorphic adenoma. However some clonal chromosomal abnormalities with aberrations involving 8q12 and 12q15 have been described. Simian virus(SV40) is thought to play a role either in the onset or progression of the tumor.
Causes
- There are no established causes for the development of pleomorphic adenoma.
- However some clonal chromosomal abnormalities with aberrations involving 8q12 and 12q15 have been described.[1]
- Oncogenic simian virus(SV40) may play a role in the onset or progression of pleomorphic adenoma.[2]
References
- ↑ Debnath SC, Adhyapok AK (June 2010). "Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip". J Maxillofac Oral Surg. 9 (2): 205–8. doi:10.1007/s12663-010-0052-5. PMID 22190789.
- ↑ Martinelli M, Martini F, Rinaldi E, Caramanico L, Magri E, Grandi E, Carinci F, Pastore A, Tognon M (October 2002). "Simian virus 40 sequences and expression of the viral large T antigen oncoprotein in human pleomorphic adenomas of parotid glands". Am. J. Pathol. 161 (4): 1127–33. doi:10.1016/S0002-9440(10)64389-1. PMC 1867276. PMID 12368186.