Merkel cell cancer history and symptoms: Difference between revisions
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{{CMG}} {{AE}} {{VKG}} | {{CMG}} {{AE}} {{VKG}} | ||
==Overview== | ==Overview== | ||
Patients with | Patients with merkel cell carcinoma usually present with a rapid growing, painless, small [[mass]] that is typically located on sun exposed area of the body. | ||
==History and Symptoms== | ==History and Symptoms== | ||
* The majority of patients with | * The majority of patients with merkel cell carcinoma are [[asymptomatic]] almost 88 percent. | ||
=== History === | === History === | ||
Patients with | Patients with merkel cell carcinoma may have a positive history of:<ref name="pmid26433246">{{cite journal |vauthors=Suárez AL, Louis P, Kitts J, Busam K, Myskowski PL, Wong RJ, Chen CS, Spencer P, Lacouture M, Pulitzer MP |title=Clinical and dermoscopic features of combined cutaneous squamous cell carcinoma (SCC)/neuroendocrine [Merkel cell] carcinoma (MCC) |journal=J. Am. Acad. Dermatol. |volume=73 |issue=6 |pages=968–75 |date=December 2015 |pmid=26433246 |pmc=5026117 |doi=10.1016/j.jaad.2015.08.041 |url=}}</ref> | ||
* Severe [[sun exposure]] | * Severe [[sun exposure]] | ||
* [[Organ transplant|Organ transplantation]] | * [[Organ transplant|Organ transplantation]] | ||
| Line 21: | Line 21: | ||
=== Common Symptoms === | === Common Symptoms === | ||
Common symptoms of [[merkel cell carcinoma]] include<ref name="pmid18280333">{{cite journal |vauthors=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF, Nghiem P |title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features |journal=J. Am. Acad. Dermatol. |volume=58 |issue=3 |pages=375–81 |date=March 2008 |pmid=18280333 |pmc=2335370 |doi=10.1016/j.jaad.2007.11.020 |url=}}</ref><ref name="pmid23574613">{{cite journal |vauthors=Jalilian C, Chamberlain AJ, Haskett M, Rosendahl C, Goh M, Beck H, Keir J, Varghese P, Mar A, Hosking S, Hussain I, Rich M, McLean C, Kelly JW |title=Clinical and dermoscopic characteristics of Merkel cell carcinoma |journal=Br. J. Dermatol. |volume=169 |issue=2 |pages=294–7 |date=August 2013 |pmid=23574613 |doi=10.1111/bjd.12376 |url=}}</ref><ref name="pmid19401065">{{cite journal |vauthors=Zhan FQ, Packianathan VS, Zeitouni NC |title=Merkel cell carcinoma: a review of current advances |journal=J Natl Compr Canc Netw |volume=7 |issue=3 |pages=333–9 |date=March 2009 |pmid=19401065 |doi= |url=}}</ref> | Common symptoms of [[merkel cell carcinoma]] include<ref name="pmid18280333">{{cite journal |vauthors=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF, Nghiem P |title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features |journal=J. Am. Acad. Dermatol. |volume=58 |issue=3 |pages=375–81 |date=March 2008 |pmid=18280333 |pmc=2335370 |doi=10.1016/j.jaad.2007.11.020 |url=}}</ref><ref name="pmid23574613">{{cite journal |vauthors=Jalilian C, Chamberlain AJ, Haskett M, Rosendahl C, Goh M, Beck H, Keir J, Varghese P, Mar A, Hosking S, Hussain I, Rich M, McLean C, Kelly JW |title=Clinical and dermoscopic characteristics of Merkel cell carcinoma |journal=Br. J. Dermatol. |volume=169 |issue=2 |pages=294–7 |date=August 2013 |pmid=23574613 |doi=10.1111/bjd.12376 |url=}}</ref><ref name="pmid19401065">{{cite journal |vauthors=Zhan FQ, Packianathan VS, Zeitouni NC |title=Merkel cell carcinoma: a review of current advances |journal=J Natl Compr Canc Netw |volume=7 |issue=3 |pages=333–9 |date=March 2009 |pmid=19401065 |doi= |url=}}</ref> | ||
* Rapid growing, painless and small [[mass]] that typically located on a sun exposed area of the body | * Rapid growing, painless and small [[mass]] that typically located on a sun exposed area of the body. | ||
* The most common location of [[merkel cell carcinoma]] is the periorbital region on the face | * The most common location of [[merkel cell carcinoma]] is the periorbital region on the face. | ||
* The [[lesions]] in [[merkel cell carcinoma]] appear as [[plaques]] or violaceous [[solitary]] and dome-shaped nodules | * The [[lesions]] in [[merkel cell carcinoma]] appear as [[plaques]] or violaceous [[solitary]] and dome-shaped nodules. | ||
* The [[nodules]] in [[merkel cell carcinoma]] appear as red or deep purple in colour | * The [[nodules]] in [[merkel cell carcinoma]] appear as red or deep purple in colour. | ||
* The most important features in [[merkel cell carcinoma]] can be summarized in an acronym: '''AEIOU''' | * The most important features in [[merkel cell carcinoma]] can be summarized in an acronym: '''AEIOU''' | ||
** '''A'''-'''[[Asymptomatic]]''' | ** '''A'''-'''[[Asymptomatic]]''' | ||
** '''E- Expanding rapidly''' | ** '''E-Expanding rapidly''' | ||
** '''I- [[Immunosuppression|Immune suppression]]''' | ** '''I-[[Immunosuppression|Immune suppression]]''' | ||
** '''O- Older than 50 years''' | ** '''O-Older than 50 years''' | ||
** '''U- [[Ultraviolet]]-exposure''' | ** '''U-[[Ultraviolet]]-exposure''' | ||
* | * | ||
Latest revision as of 02:39, 31 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Patients with merkel cell carcinoma usually present with a rapid growing, painless, small mass that is typically located on sun exposed area of the body.
History and Symptoms
- The majority of patients with merkel cell carcinoma are asymptomatic almost 88 percent.
History
Patients with merkel cell carcinoma may have a positive history of:[1]
- Severe sun exposure
- Organ transplantation
- Viral infection like
- MCPvY
- HIV
- Taking immunosuppressive medications
Common Symptoms
Common symptoms of merkel cell carcinoma include[2][3][4]
- Rapid growing, painless and small mass that typically located on a sun exposed area of the body.
- The most common location of merkel cell carcinoma is the periorbital region on the face.
- The lesions in merkel cell carcinoma appear as plaques or violaceous solitary and dome-shaped nodules.
- The nodules in merkel cell carcinoma appear as red or deep purple in colour.
- The most important features in merkel cell carcinoma can be summarized in an acronym: AEIOU
- A-Asymptomatic
- E-Expanding rapidly
- I-Immune suppression
- O-Older than 50 years
- U-Ultraviolet-exposure
References
- ↑ Suárez AL, Louis P, Kitts J, Busam K, Myskowski PL, Wong RJ, Chen CS, Spencer P, Lacouture M, Pulitzer MP (December 2015). "Clinical and dermoscopic features of combined cutaneous squamous cell carcinoma (SCC)/neuroendocrine [Merkel cell] carcinoma (MCC)". J. Am. Acad. Dermatol. 73 (6): 968–75. doi:10.1016/j.jaad.2015.08.041. PMC 5026117. PMID 26433246.
- ↑ Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF, Nghiem P (March 2008). "Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features". J. Am. Acad. Dermatol. 58 (3): 375–81. doi:10.1016/j.jaad.2007.11.020. PMC 2335370. PMID 18280333.
- ↑ Jalilian C, Chamberlain AJ, Haskett M, Rosendahl C, Goh M, Beck H, Keir J, Varghese P, Mar A, Hosking S, Hussain I, Rich M, McLean C, Kelly JW (August 2013). "Clinical and dermoscopic characteristics of Merkel cell carcinoma". Br. J. Dermatol. 169 (2): 294–7. doi:10.1111/bjd.12376. PMID 23574613.
- ↑ Zhan FQ, Packianathan VS, Zeitouni NC (March 2009). "Merkel cell carcinoma: a review of current advances". J Natl Compr Canc Netw. 7 (3): 333–9. PMID 19401065.