Sandbox:Roukoz

Diseases	Clinical manifestations						Para-clinical findings							Gold standard	Additional findings
	Symptoms			Physical examination
							Lab Findings			Imaging			Histopathology
	Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Lab 1	Lab 2	Lab 3	Imaging 1	Imaging 2	Imaging 3
Cutaneous squamous cell carcinoma	pain	erythema		indurated	hyperkeratotic	increased size								skin biopsy	60 percent of squamous cell carcinomas occur at the site of a previous actinic keratosis
Merkel cell carcinoma				Starts on areas of skin exposed to the sun	Single pink, red, or purple shiny bump	Painless								Skin biopsy	blue-red, dome-shaped nodule
Nodular malignant melanoma															Two-thirds arise in normal skin, the rest in existing moles Genetic component in some cases with a positive family history
Amelanotic melanoma				Color usually pink, purple or normal skin color	Usually have an asymmetrical shape with an irregular border	red, nonspecific lesion with slightly elevated borders								skin biopsy	Do not make melanin, so lesions are not pigmented
Basal cell carcinoma				Coarse scale lesion
Superficial basal cell carcinoma				scaly patch	erythematous lesion								large, hyperchromatic, oval nuclei and little cytoplasm well differentiated and cells appear histologically similar to basal cells of the epidermis	skin biopsy
Nodular basal cell carcinoma				Pearly papule with telangiectasias										Skin biopsy
Cutaneous metastases of internal malignancy
Benign Skin Lesions
Sebaceous cell carcinoma
rhabdomyosarcoma
Actinic keratoses	pain			hyperkeratosis	erythema	less pigmentation, and tend to be somewhat smaller in size.								Skin biopsy
Prurigo nodules	Hard lesion	Itchy lumps
Paget disease
Inflamed seborrheic keratosis				waxy, "stuck on," often hyperkeratotic appearance						On dermatoscopic evaluation, presence of horned cysts and hairpin-shaped blood vessels				Skin biopsy
Viral warts				Verrucous lesion											Caused by HPV
Pyogenic granuloma				Rapidly growing	Red, dome-shaped	Friable papule with a collarette of scale
Bowenoid papulosis				multiple, red- to brown-colored, small papules that											primarily arise on genitals induced by human papillomavirus (HPV) infection
Nummular eczema	Itchy lesions			Coin shaped spots											Chronic condition
Psoriasis
Pyoderma gangrenosum				Purulent ulcer	Ragged and violaceous border
Venous stasis ulcers
Traumatic ulcers
Bowen Disease
Sebaceous Hyperplasia
Allergic Contact Dermatitis	Itchy rash			Red rash											Not contagious
Atopic Dermatitis	Itchy rash	Fever		Red rash											Chronic and sometimes accompanied by asthma
Atypical Fibroxanthoma				Erythematous, dome-shaped papule
Nevus
Chemical Burns
Limbal Dermoid													Contains choristomatous tissue		Benign congenital tumor
Benign hereditary intraepithelial dyskeratosis
primary acquired melanosis
Fibrous xanthoma													Containing fibromatous elements		Arises due to disturbed systemic lipid metabolism
Inflamed seborrheic keratosis				Inflamed and hyperpigmented
Juvenile xanthogranuloma				Reddened, yellowish-tan color of lesions	Slightly raised bumps										Typically