Chronic neutrophilic leukemia interventions: Difference between revisions

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The mainstay of treatment for TT is medical therapy.
The mainstay of treatment for TT is medical therapy.
*[[Hematopoietic stem cell transplantation|Hematopoitic stem cell transplant]] (HSCT):  HSCT is the only potential therapeutic option for patients with CNL. It is recommended that every [[Patient|patients]] that are qualified for HSCT, take this treatment. Since, the therapy in [[blast]] phases has the poor [[outcome]]<nowiki/>s, HSCT should be started as soon as possible in the disease course, before blast transformation.<ref name="ElliottHanson2004">{{cite journal|last1=Elliott|first1=M A|last2=Hanson|first2=C A|last3=Dewald|first3=G W|last4=Smoley|first4=S A|last5=Lasho|first5=T L|last6=Tefferi|first6=A|title=WHO-defined chronic neutrophilic leukemia: a long-term analysis of 12 cases and a critical review of the literature|journal=Leukemia|volume=19|issue=2|year=2004|pages=313–317|issn=0887-6924|doi=10.1038/sj.leu.2403562}}</ref><ref name="KakoKanda2007">{{cite journal|last1=Kako|first1=Shinichi|last2=Kanda|first2=Yoshinobu|last3=Sato|first3=Tomohiko|last4=Goyama|first4=Susumu|last5=Noda|first5=Naohiro|last6=Shoda|first6=Eriko|last7=Oshima|first7=Kumi|last8=Inoue|first8=Morihiro|last9=Izutsu|first9=Koji|last10=Watanabe|first10=Takuro|last11=Motokura|first11=Toru|last12=Chiba|first12=Shigeru|last13=Fukayama|first13=Masashi|last14=Kurokawa|first14=Mineo|title=Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation|journal=American Journal of Hematology|volume=82|issue=5|year=2007|pages=386–390|issn=03618609|doi=10.1002/ajh.20805}}</ref><ref name="SzuberTefferi2018">{{cite journal|last1=Szuber|first1=Natasha|last2=Tefferi|first2=Ayalew|title=Chronic neutrophilic leukemia: new science and new diagnostic criteria|journal=Blood Cancer Journal|volume=8|issue=2|year=2018|issn=2044-5385|doi=10.1038/s41408-018-0049-8}}</ref><ref name="CigudosaMenezes2015">{{cite journal|last1=Cigudosa|first1=Juan C|last2=Menezes|first2=Juliane|title=Chronic neutrophilic leukemia: a clinical perspective|journal=OncoTargets and Therapy|year=2015|pages=2383|issn=1178-6930|doi=10.2147/OTT.S49688}}</ref>
*[[Hematopoietic stem cell transplantation|Hematopoitic stem cell transplant]] (HSCT):  HSCT is the only potential therapeutic option for patients with CNL. It is recommended that every [[Patient|patients]] that are qualified for HSCT, take this treatment. Since, the therapy in [[blast]] phases has the poor [[outcome]]<nowiki/>s, HSCT should be started as soon as possible in the disease course, before blast transformation.<ref name="ElliottHanson2004">{{cite journal|last1=Elliott|first1=M A|last2=Hanson|first2=C A|last3=Dewald|first3=G W|last4=Smoley|first4=S A|last5=Lasho|first5=T L|last6=Tefferi|first6=A|title=WHO-defined chronic neutrophilic leukemia: a long-term analysis of 12 cases and a critical review of the literature|journal=Leukemia|volume=19|issue=2|year=2004|pages=313–317|issn=0887-6924|doi=10.1038/sj.leu.2403562}}</ref><ref name="KakoKanda2007">{{cite journal|last1=Kako|first1=Shinichi|last2=Kanda|first2=Yoshinobu|last3=Sato|first3=Tomohiko|last4=Goyama|first4=Susumu|last5=Noda|first5=Naohiro|last6=Shoda|first6=Eriko|last7=Oshima|first7=Kumi|last8=Inoue|first8=Morihiro|last9=Izutsu|first9=Koji|last10=Watanabe|first10=Takuro|last11=Motokura|first11=Toru|last12=Chiba|first12=Shigeru|last13=Fukayama|first13=Masashi|last14=Kurokawa|first14=Mineo|title=Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation|journal=American Journal of Hematology|volume=82|issue=5|year=2007|pages=386–390|issn=03618609|doi=10.1002/ajh.20805}}</ref><ref name="SzuberTefferi2018">{{cite journal|last1=Szuber|first1=Natasha|last2=Tefferi|first2=Ayalew|title=Chronic neutrophilic leukemia: new science and new diagnostic criteria|journal=Blood Cancer Journal|volume=8|issue=2|year=2018|issn=2044-5385|doi=10.1038/s41408-018-0049-8}}</ref><ref name="CigudosaMenezes2015">{{cite journal|last1=Cigudosa|first1=Juan C|last2=Menezes|first2=Juliane|title=Chronic neutrophilic leukemia: a clinical perspective|journal=OncoTargets and Therapy|year=2015|pages=2383|issn=1178-6930|doi=10.2147/OTT.S49688}}</ref><ref name="TabbaraZimmerman2002">{{cite journal|last1=Tabbara|first1=Imad A.|last2=Zimmerman|first2=Kathy|last3=Morgan|first3=Connie|last4=Nahleh|first4=Zeina|title=Allogeneic Hematopoietic Stem Cell Transplantation|journal=Archives of Internal Medicine|volume=162|issue=14|year=2002|pages=1558|issn=0003-9926|doi=10.1001/archinte.162.14.1558}}</ref>
*complications and side effects of this therapy include:
 
*Infection
**complications and side effects of this therapy include:
*Veno-occlusive disease
***Infection
*Mucositis
***Veno-occlusive disease
*Graft-versus-host disease (GVHD)
***Mucositis
*Graft versus tumor effect
***Graft-versus-host disease (GVHD)
***Graft versus tumor effect
*[[Splenic]] [[irradiation]]
*[[Splenic]] [[irradiation]]


Revision as of 16:09, 5 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]

Overview

There are no recommended therapeutic interventions for the management of [disease name].

OR

[Name of intervention] is not the first-line treatment option for patients with [disease name]. [Name of intervention] is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]

OR

The mainstay of treatment for [disease name] is medical therapy/surgery. [Name of intervention] is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].

OR

The feasibility of [name of intervention] depends on the stage of [disease or malignancy] at the time of diagnosis.

OR

[Name of intervention] is the mainstay of treatment for [disease or malignancy].

Indications

The mainstay of treatment for TT is medical therapy.

  • Hematopoitic stem cell transplant (HSCT): HSCT is the only potential therapeutic option for patients with CNL. It is recommended that every patients that are qualified for HSCT, take this treatment. Since, the therapy in blast phases has the poor outcomes, HSCT should be started as soon as possible in the disease course, before blast transformation.[1][2][3][4][5]
    • complications and side effects of this therapy include:
      • Infection
      • Veno-occlusive disease
      • Mucositis
      • Graft-versus-host disease (GVHD)
      • Graft versus tumor effect
  • Splenic irradiation

References

  1. ↑ Elliott, M A; Hanson, C A; Dewald, G W; Smoley, S A; Lasho, T L; Tefferi, A (2004). "WHO-defined chronic neutrophilic leukemia: a long-term analysis of 12 cases and a critical review of the literature". Leukemia. 19 (2): 313–317. doi:10.1038/sj.leu.2403562. ISSN 0887-6924.
  2. ↑ Kako, Shinichi; Kanda, Yoshinobu; Sato, Tomohiko; Goyama, Susumu; Noda, Naohiro; Shoda, Eriko; Oshima, Kumi; Inoue, Morihiro; Izutsu, Koji; Watanabe, Takuro; Motokura, Toru; Chiba, Shigeru; Fukayama, Masashi; Kurokawa, Mineo (2007). "Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation". American Journal of Hematology. 82 (5): 386–390. doi:10.1002/ajh.20805. ISSN 0361-8609.
  3. ↑ Szuber, Natasha; Tefferi, Ayalew (2018). "Chronic neutrophilic leukemia: new science and new diagnostic criteria". Blood Cancer Journal. 8 (2). doi:10.1038/s41408-018-0049-8. ISSN 2044-5385.
  4. ↑ Cigudosa, Juan C; Menezes, Juliane (2015). "Chronic neutrophilic leukemia: a clinical perspective". OncoTargets and Therapy: 2383. doi:10.2147/OTT.S49688. ISSN 1178-6930.
  5. ↑ Tabbara, Imad A.; Zimmerman, Kathy; Morgan, Connie; Nahleh, Zeina (2002). "Allogeneic Hematopoietic Stem Cell Transplantation". Archives of Internal Medicine. 162 (14): 1558. doi:10.1001/archinte.162.14.1558. ISSN 0003-9926.

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