Bladder cancer differential diagnosis: Difference between revisions
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Bladder cancer]]<ref name="pmid21360040">{{cite journal| author=Pons F, Orsola A, Morote J, Bellmunt J| title=Variant forms of bladder cancer: basic considerations on treatment approaches. | journal=Curr Oncol Rep | year= 2011 | volume= 13 | issue= 3 | pages= 216-21 | pmid=21360040 | doi=10.1007/s11912-011-0161-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21360040 }}</ref><ref name="pmid10918764">{{cite journal |vauthors=Metts MC, Metts JC, Milito SJ, Thomas CR |title=Bladder cancer: a review of diagnosis and management |journal=J Natl Med Assoc |volume=92 |issue=6 |pages=285–94 |date=June 2000 |pmid=10918764 |pmc=2640522 |doi= |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Bladder cancer]]<ref name="pmid21360040">{{cite journal| author=Pons F, Orsola A, Morote J, Bellmunt J| title=Variant forms of bladder cancer: basic considerations on treatment approaches. | journal=Curr Oncol Rep | year= 2011 | volume= 13 | issue= 3 | pages= 216-21 | pmid=21360040 | doi=10.1007/s11912-011-0161-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21360040 }}</ref><ref name="pmid10918764">{{cite journal |vauthors=Metts MC, Metts JC, Milito SJ, Thomas CR |title=Bladder cancer: a review of diagnosis and management |journal=J Natl Med Assoc |volume=92 |issue=6 |pages=285–94 |date=June 2000 |pmid=10918764 |pmc=2640522 |doi= |url=}}</ref><ref name="pmid182316182">{{cite journal |vauthors=Rom M, Kuehhas FE, Djavan B |title=New findings in bladder and prostate cancer: highlights of the 22nd annual congress of the European association of urology, march 21-24, 2007, berlin, Germany |journal=Rev Urol |volume=9 |issue=4 |pages=214–9 |date=2007 |pmid=18231618 |pmc=2199502 |doi= |url=}}</ref> | ||
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Prostate cancer]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Prostate cancer]]<ref name="pmid23451265">{{cite journal |vauthors=Chung SD, Liu SP, Lin HC |title=Association between prostate cancer and urinary calculi: a population-based study |journal=PLoS ONE |volume=8 |issue=2 |pages=e57743 |date=2013 |pmid=23451265 |pmc=3581486 |doi=10.1371/journal.pone.0057743 |url=}}</ref><ref name="pmid18231618">{{cite journal |vauthors=Rom M, Kuehhas FE, Djavan B |title=New findings in bladder and prostate cancer: highlights of the 22nd annual congress of the European association of urology, march 21-24, 2007, berlin, Germany |journal=Rev Urol |volume=9 |issue=4 |pages=214–9 |date=2007 |pmid=18231618 |pmc=2199502 |doi= |url=}}</ref> | ||
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Familial|Familial diseases]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Familial|Familial diseases]] | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Polycystic kidney disease]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Polycystic kidney disease]]'''<ref name="pmid8321262">{{cite journal |vauthors=Gabow PA |title=Autosomal dominant polycystic kidney disease |journal=N. Engl. J. Med. |volume=329 |issue=5 |pages=332–42 |date=July 1993 |pmid=8321262 |doi=10.1056/NEJM199307293290508 |url=}}</ref><ref name="pmid16523049">{{cite journal |vauthors=Adeva M, El-Youssef M, Rossetti S, Kamath PS, Kubly V, Consugar MB, Milliner DM, King BF, Torres VE, Harris PC |title=Clinical and molecular characterization defines a broadened spectrum of autosomal recessive polycystic kidney disease (ARPKD) |journal=Medicine (Baltimore) |volume=85 |issue=1 |pages=1–21 |date=January 2006 |pmid=16523049 |doi=10.1097/01.md.0000200165.90373.9a |url=}}</ref>''' | ||
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| rowspan="3" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Vascular anomaly|Vascular diseases]] | | rowspan="3" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Vascular anomaly|Vascular diseases]] | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Renal vein thrombosis]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Renal vein thrombosis]]<ref>{{Cite journal | ||
| author = [[U. Kuhlmann]], [[J. Steurer]], [[A. Bollinger]], [[G. Pouliadis]], [[J. Briner]] & [[W. Siegenthaler]] | |||
| title = [Incidence and clinical significance of thromboses and thrombo-embolic complications in nephrotic syndrome patients] | |||
| journal = [[Schweizerische medizinische Wochenschrift]] | |||
| volume = 111 | |||
| issue = 27-28 | |||
| pages = 1034–1040 | |||
| year = 1981 | |||
| month = July | |||
| pmid = 7268357 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[F. Llach]], [[S. Papper]] & [[S. G. Massry]] | |||
| title = The clinical spectrum of renal vein thrombosis: acute and chronic | |||
| journal = [[The American journal of medicine]] | |||
| volume = 69 | |||
| issue = 6 | |||
| pages = 819–827 | |||
| year = 1980 | |||
| month = December | |||
| pmid = 7446547 | |||
}}</ref> | |||
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| style="background: #F5F5F5; padding: 5px;" |'''Renal venography:''' Gold standard | | style="background: #F5F5F5; padding: 5px;" |'''Renal venography:''' Gold standard | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Granulomatosis with polyangiitis|Wegner's granulomatosis polyangiitis]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Granulomatosis with polyangiitis|Wegner's granulomatosis polyangiitis]]<ref name="pmid27733943">{{cite journal| author=Pagnoux C| title=Updates in ANCA-associated vasculitis. | journal=Eur J Rheumatol | year= 2016 | volume= 3 | issue= 3 | pages= 122-133 | pmid=27733943 | doi=10.5152/eurjrheum.2015.0043 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27733943 }}</ref><ref name="pmid12541109">{{cite journal |vauthors=Lee KS, Kim TS, Fujimoto K, Moriya H, Watanabe H, Tateishi U, Ashizawa K, Johkoh T, Kim EA, Kwon OJ |title=Thoracic manifestation of Wegener's granulomatosis: CT findings in 30 patients |journal=Eur Radiol |volume=13 |issue=1 |pages=43–51 |year=2003 |pmid=12541109 |doi=10.1007/s00330-002-1422-2 |url=}}</ref><ref name="pmid17133251">{{cite journal| author=Kallenberg CG, Heeringa P, Stegeman CA| title=Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides. | journal=Nat Clin Pract Rheumatol | year= 2006 | volume= 2 | issue= 12 | pages= 661-70 | pmid=17133251 | doi=10.1038/ncprheum0355 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17133251 }}</ref><ref name="pmid93665842">{{cite journal |vauthors=Jennette JC, Falk RJ |title=Small-vessel vasculitis |journal=N. Engl. J. Med. |volume=337 |issue=21 |pages=1512–23 |date=November 1997 |pmid=9366584 |doi=10.1056/NEJM199711203372106 |url=}}</ref> | ||
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| style="background: #F5F5F5; padding: 5px;" |Biopsy | | style="background: #F5F5F5; padding: 5px;" |Biopsy | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Henoch-Schönlein purpura]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Henoch-Schönlein purpura]]<ref name="pmid9366584">{{cite journal |vauthors=Jennette JC, Falk RJ |title=Small-vessel vasculitis |journal=N. Engl. J. Med. |volume=337 |issue=21 |pages=1512–23 |date=November 1997 |pmid=9366584 |doi=10.1056/NEJM199711203372106 |url=}}</ref><ref name="pmid25557596">{{cite journal |vauthors=Chen JY, Mao JH |title=Henoch-Schönlein purpura nephritis in children: incidence, pathogenesis and management |journal=World J Pediatr |volume=11 |issue=1 |pages=29–34 |date=February 2015 |pmid=25557596 |doi=10.1007/s12519-014-0534-5 |url=}}</ref> | ||
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Urolithiasis]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Urolithiasis]]<ref name="pmid126499872">{{cite journal |vauthors=Hochreiter W, Knoll T, Hess B |title=[Pathophysiology, diagnosis and conservative therapy of non-calcium kidney calculi] |language=German |journal=Ther Umsch |volume=60 |issue=2 |pages=89–97 |date=February 2003 |pmid=12649987 |doi=10.1024/0040-5930.60.2.89 |url=}}</ref><ref name="pmid24818849">{{cite journal |vauthors=Flannigan R, Choy WH, Chew B, Lange D |title=Renal struvite stones--pathogenesis, microbiology, and management strategies |journal=Nat Rev Urol |volume=11 |issue=6 |pages=333–41 |date=June 2014 |pmid=24818849 |doi=10.1038/nrurol.2014.99 |url=}}</ref><ref name="pmid25685869">{{cite journal |vauthors=Pereira DJ, Schoolwerth AC, Pais VM |title=Cystinuria: current concepts and future directions |journal=Clin. Nephrol. |volume=83 |issue=3 |pages=138–46 |date=March 2015 |pmid=25685869 |doi= |url=}}</ref> | ||
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| style="background: #F5F5F5; padding: 5px;" | +/- | | style="background: #F5F5F5; padding: 5px;" | +/- | ||
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| rowspan="4" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Infectious disease|Infectious diseases]] | | rowspan="4" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Infectious disease|Infectious diseases]] | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Pyelonephritis]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Pyelonephritis]]<ref name="pmid256858692">{{cite journal |vauthors=Pereira DJ, Schoolwerth AC, Pais VM |title=Cystinuria: current concepts and future directions |journal=Clin. Nephrol. |volume=83 |issue=3 |pages=138–46 |date=March 2015 |pmid=25685869 |doi= |url=}}</ref><ref name="pmid18092884">{{cite journal| author=Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ| title=Detection of intracellular bacterial communities in human urinary tract infection. | journal=PLoS Med | year= 2007 | volume= 4 | issue= 12 | pages= e329 | pmid=18092884 | doi=10.1371/journal.pmed.0040329 | pmc=2140087 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18092884 }}</ref> | ||
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Cystitis]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Cystitis]]<ref name="pmid16298166">{{cite journal| author=Franco AV| title=Recurrent urinary tract infections. | journal=Best Pract Res Clin Obstet Gynaecol | year= 2005 | volume= 19 | issue= 6 | pages= 861-73 | pmid=16298166 | doi=10.1016/j.bpobgyn.2005.08.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16298166 }}</ref><ref name="pmid162981662">{{cite journal| author=Franco AV| title=Recurrent urinary tract infections. | journal=Best Pract Res Clin Obstet Gynaecol | year= 2005 | volume= 19 | issue= 6 | pages= 861-73 | pmid=16298166 | doi=10.1016/j.bpobgyn.2005.08.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16298166 }}</ref> | ||
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| style="background: #F5F5F5; padding: 5px;" |Urine culture | | style="background: #F5F5F5; padding: 5px;" |Urine culture | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Prostatitis]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Prostatitis]]<ref>{{Cite journal | ||
| author = [[John N. Krieger]], [[Ulrich Dobrindt]], [[Donald E. Riley]] & [[Eric Oswald]] | |||
| title = Acute Escherichia coli prostatitis in previously health young men: bacterial virulence factors, antimicrobial resistance, and clinical outcomes | |||
| journal = [[Urology]] | |||
| volume = 77 | |||
| issue = 6 | |||
| pages = 1420–1425 | |||
| year = 2011 | |||
| month = June | |||
| doi = 10.1016/j.urology.2010.12.059 | |||
| pmid = 21459419 | |||
}}</ref><ref name="pmid20704171">{{cite journal| author=Sharp VJ, Takacs EB, Powell CR| title=Prostatitis: diagnosis and treatment. | journal=Am Fam Physician | year= 2010 | volume= 82 | issue= 4 | pages= 397-406 | pmid=20704171 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20704171 }}</ref> | |||
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Revision as of 16:12, 5 February 2019
Bladder cancer Microchapters |
Diagnosis |
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Bladder cancer differential diagnosis On the Web |
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Risk calculators and risk factors for Bladder cancer differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Bladder cancer must be differentiated from renal cancer, renal stones, prostate cancer, and cystitis.
Differential Diagnosis
The most common presentation of bladder cancer is hematuria, in the advanced cases, the presentation can be bladder mass. Bladder cancer must be differentiated from other causes of hematuria as in the below table:
Diseases | Clinical manifestations | Para-clinical findings | Gold standard | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Symptoms | Physical examina | ||||||||||||
Lab Findings | Diagnosi | ||||||||||||
Low back pain | Fever | Nausea/
Vomiting |
Urinary symptoms | Hypertension | Pitting edema | Other | |||||||
Dysuria | Frequency | Oliguria | |||||||||||
Glomerular diseases | IgA nephropathy[1][2] (Berger nephropathy) | + | - | - | - | + | + | + | - | - | Biopsy:
IgA deposited in a diffuse granular patte-rn in the mesangium |
Biopsy
| |
Hereditary nephritis[3][4] (Alport syndrome) | - | - | - | - | - | - | + | - |
|
Biopsy:
|
Genetic analysis | ||
Post-streptococcal glomerulonephritis[5][6] | +/- | + | - | - | + | + | + | + |
|
|
Biopsy
|
Biopsy | |
Focal segmental glomerular sclerosis[7][8][9] | - | - | - | - | - | - | + | + |
|
|
Biopsy
|
Biopsy | |
Rapidly progressive glomerulonephritis[10][11][12] | + | + | + | - | - | - | + | - |
|
|
Biopsy:
|
Biopsy | |
Lupus nephritis[13][14] | - | + | - | - | - | - | + | + |
|
|
Biopsy,
|
Biopsy | |
Fabry disease | - | - | - | - | - | - | + | + | - |
|
Biopsy | Biopsy | |
Disease | Low back pain | Fever | Nausea/
Vomiting |
Dysuria | Frequency | Oliguria | Hypertension | Pitting edema | Other | Lab Findings | Diagnosis method | Gold standard | |
Tubulointerstitial diseases[15][16][17] | + | + | + | – | – | – | – | – | Rash | Biopsy:
|
Renal biopsy | ||
Nephrolithiasis[18][19] | + | ± | + | ± | ± | ± | – | – |
|
|
Abdominal CT scan without contrast | ||
Reflux nephropathy (hydronephrosis) | + | + | - | - | - | - | - | + |
|
– | |||
Malignancy | Renal cell carcinoma (RCC)[20][21] | - | - | - | - | - | - | ± | ± |
|
|
|
– |
Nephroblastoma (Wilms tumor)[22][23] | - | - | - | - | - | - | - | - |
|
Biopsy:
|
Biopsy | ||
Bladder cancer[27][28][29] | - | - | - | - | ± | ± | - | - | Suprapubic pain | Ultrasound, CT scan, Biopsy | Biopsy | ||
Prostate cancer[30][31] | ± | - | - | - | ± | ± | - | - | - | Ultrasound, CT scan, Biopsy | Biopsy | ||
Disease | Low back pain | Fever | Nausea/
Vomiting |
Dysuria | Frequency | Oliguria | Hypertension | Pitting edema | Other | Lab Findings | Diagnosis method | Gold standard | |
Familial diseases | Polycystic kidney disease[32][33] | + | - | - | - | - | - | + | + |
|
Ultrasound:
CT:
Genetic testing demonstrates: Biopsy:
|
Ultrasound | |
Vascular diseases | Renal vein thrombosis[34][35] | + | + | + | - | - | - | - | - |
|
|
|
Renal venography: Gold standard |
Wegner's granulomatosis polyangiitis[36][37][38][39] | - | - | - | - | - | +/- | + | + |
|
|
CT chest:
Biopsy:
|
Biopsy | |
Henoch-Schönlein purpura[40][41] | - | - | - | - | - | +/- | +/- | + |
|
|
Biopsy:
IgA deposited in a diffuse granular pattern in the mesangium |
Renal biopsy, and clinical syndrome | |
Disease | Low back pain | Fever | Nausea/
Vomiting |
Dysuria | Frequency | Oliguria | Hypertension | Pitting edema | Other | Lab Findings | Diagnosis method | Gold standard | |
Lower urinary tract diseases | Benign prostatic hyperplasia | +/- | - | - | + | + | - | - | - |
|
|
|
Biopsy |
Urolithiasis[42][43][44] | + | +/- | + | + | + | + | - | - | Flank, groin pain |
|
Abdominppelvic CT scan without contrast | Abdominppelvic CT scan without contrast | |
Disease | Low back pain | Fever | Nausea/
Vomiting |
Dysuria | Frequency | Oliguria | Hypertension | Pitting edema | Other | Lab Findings | Diagnosis method | Gold standard | |
Infectious diseases | Pyelonephritis[45][46] | + | + | + | + | + | + | - | - |
|
CT and ultrasound: | - | |
Cystitis[47][48] | - | - | - | + | + | + | - | - |
|
|
|
Urine culture | |
Prostatitis[49][50] | - | + | - | + | + | + | - | - |
|
|
Ultrasound:
CT scan:
|
- | |
Urethritis | -/- | + | - | + | + | + | - | - |
|
|
CT scan:
|
Urine culture | |
Urogenital trauma | Inserted bladder or ureteral catheters | - | - | - | + | + | + | - | - |
|
Hematuria | Retrograde Urethrography | Retrograde Urethrography |
Lower abdominal mass can be classified to the gynecological and non-gynecological causes. Bladder cancer in the advanced cases can present as a bladder mass. Below table discusses lower abdominal mass causes:
References
- ↑ Donadio JV, Grande JP (2002). "IgA nephropathy". N Engl J Med. 347 (10): 738–48. doi:10.1056/NEJMra020109. PMID 12213946.
- ↑ Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, Renfrow MB; et al. (2011). "The pathophysiology of IgA nephropathy". J Am Soc Nephrol. 22 (10): 1795–803. doi:10.1681/ASN.2011050464. PMID 21949093.
- ↑ McCarthy PA, Maino DM (2000). "Alport syndrome: a review". Clin Eye Vis Care. 12 (3–4): 139–150. PMID 11137428.
- ↑ Bodziak KA, Hammond WS, Molitoris BA (1994). "Inherited diseases of the glomerular basement membrane". Am J Kidney Dis. 23 (4): 605–18. PMID 8154501.
- ↑ Yoshizawa N, Yamakami K, Fujino M, Oda T, Tamura K, Matsumoto K, Sugisaki T, Boyle MD (July 2004). "Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response". J. Am. Soc. Nephrol. 15 (7): 1785–93. PMID 15213266.
- ↑ Oda T, Yoshizawa N, Yamakami K, Tamura K, Kuroki A, Sugisaki T, Sawanobori E, Higashida K, Ohtomo Y, Hotta O, Kumagai H, Miura S (September 2010). "Localization of nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis". Hum. Pathol. 41 (9): 1276–85. doi:10.1016/j.humpath.2010.02.006. PMID 20708459.
- ↑ Kwoh C, Shannon MB, Miner JH, Shaw A (2006). "Pathogenesis of nonimmune glomerulopathies". Annu Rev Pathol. 1: 349–74. doi:10.1146/annurev.pathol.1.110304.100119. PMID 18039119.
- ↑ Reidy K, Kaskel FJ (March 2007). "Pathophysiology of focal segmental glomerulosclerosis". Pediatr. Nephrol. 22 (3): 350–4. doi:10.1007/s00467-006-0357-2. PMC 1794138. PMID 17216262.
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ignored (help) - ↑ F. Llach, S. Papper & S. G. Massry (1980). "The clinical spectrum of renal vein thrombosis: acute and chronic". The American journal of medicine. 69 (6): 819–827. PMID 7446547. Unknown parameter
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- ↑ Hochreiter W, Knoll T, Hess B (February 2003). "[Pathophysiology, diagnosis and conservative therapy of non-calcium kidney calculi]". Ther Umsch (in German). 60 (2): 89–97. doi:10.1024/0040-5930.60.2.89. PMID 12649987.
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ignored (help) - ↑ Sharp VJ, Takacs EB, Powell CR (2010). "Prostatitis: diagnosis and treatment". Am Fam Physician. 82 (4): 397–406. PMID 20704171.