Mycosis fungoides history and symptoms: Difference between revisions
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==History and Symptoms== | ==History and Symptoms== | ||
===History=== | ===History=== | ||
*The majority of patients with mycosis fungoides | *The majority of [[Patient|patients]] with mycosis fungoides is present with:<ref name="FossGirardi2017">{{cite journal|last1=Foss|first1=Francine M.|last2=Girardi|first2=Michael|title=Mycosis Fungoides and Sezary Syndrome|journal=Hematology/Oncology Clinics of North America|volume=31|issue=2|year=2017|pages=297–315|issn=08898588|doi=10.1016/j.hoc.2016.11.008}}</ref> | ||
**Skin patches and plaques | **Skin patches and plaques | ||
**Skin erythema with or without exfoliation | **Skin erythema with or without exfoliation | ||
Revision as of 18:51, 6 February 2019
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Mycosis fungoides Microchapters |
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Mycosis fungoides history and symptoms On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
The most common symptoms of mycosis fungoides include fever, weight loss, skin rash, night sweats, itching, chest pain, abdominal pain, and bone pain.[1]
History and Symptoms
History
- The majority of patients with mycosis fungoides is present with:[2]
- Patients with advanced disease may have a positive history of with cutaneous tumors or nodules or diffuse skin erythema with or without exfoliation.
- Skin lesions in the disease obserevedc in non–sunexposed areas (bathing trunk distribution) and lesions may be hyperpigmented or hypopigmented, or may ulcerate.
- Tumors
- > 1 cm in size (depth or vertical growth)
Diagnosis criteria from the International Society for Cutaneous Lymphoma is:[2][4]
| Criteria | Major( 2pinots) | Minor(1point) |
|---|---|---|
| Persistent and/or progressive patches and plaques plus | Any 2 | Any 1 |
| 1. Non–sun-exposed location | ||
| 2.Size/shape variation | ||
| 3.Poikiloderma | ||
| Histopathologic | ||
| Superficial lymphoid infiltrate plus | Both | Either |
| 1. Epidermotropism | ||
| Molecular/biological | ||
| 2. Atypia | ||
| Clonal TCR gene rearrangement | Present | |
| Immunopathologic | ||
| 1. CD2, CD3, CD5 in <59% of T cells | Any 1 | |
| 2. CD7 in <10% of T cells | ||
| 3. Epidermal discordance from expression of CD2, CD3, CD5, and CD7 on dermal T cells | ||
Common Symptoms
Symptoms of cutaneous T cell lymphoma include:[1]
References
- ↑ 1.0 1.1 Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016
- ↑ 2.0 2.1 Foss, Francine M.; Girardi, Michael (2017). "Mycosis Fungoides and Sezary Syndrome". Hematology/Oncology Clinics of North America. 31 (2): 297–315. doi:10.1016/j.hoc.2016.11.008. ISSN 0889-8588.
- ↑ 3.0 3.1 Vonderheid, Eric C.; Bernengo, Maria Grazia; Burg, Günter; Duvic, Madeleine; Heald, Peter; Laroche, Liliane; Olsen, Elise; Pittelkow, Mark; Russell-Jones, Robin; Takigawa, Masahiro; Willemze, Rein (2002). "Update on erythrodermic cutaneous T-cell lymphoma: Report of the international society for cutaneous lymphomas". Journal of the American Academy of Dermatology. 46 (1): 95–106. doi:10.1067/mjd.2002.118538. ISSN 0190-9622.
- ↑ Pimpinelli, Nicola; Olsen, Elise A.; Santucci, Marco; Vonderheid, Eric; Haeffner, Andreas C.; Stevens, Seth; Burg, Guenter; Cerroni, Lorenzo; Dreno, Brigitte; Glusac, Earl; Guitart, Joan; Heald, Peter W.; Kempf, Werner; Knobler, Robert; Lessin, Stuart; Sander, Christian; Smoller, Bruce S.; Telang, Gladys; Whittaker, Sean; Iwatsuki, Keiji; Obitz, Erik; Takigawa, Masahiro; Turner, Maria L.; Wood, Gary S. (2005). "Defining early mycosis fungoides". Journal of the American Academy of Dermatology. 53 (6): 1053–1063. doi:10.1016/j.jaad.2005.08.057. ISSN 0190-9622.