Chronic lymphocytic leukemia history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
25-50% patients of chronic lymphocytic leukemia are usually asymptomatic with incidental absolute lymphocytosis finding on a routine blood examination. The onset of chronic lymphocytic leukemia is insidious and can present with wide range of symptoms. Symptoms of chronic lymphocytic leukemia include lymph node swelling and B symptoms including [[fever]], [[weight loss]], [[night sweats]], fatigue and recurrent | 25-50% patients of chronic lymphocytic leukemia are usually asymptomatic with incidental absolute lymphocytosis finding on a routine blood examination. The onset of chronic lymphocytic leukemia is insidious and can present with wide range of symptoms. Symptoms of chronic lymphocytic leukemia include lymph node swelling and B symptoms including [[fever]], [[weight loss]], [[night sweats]], fatigue and recurrent bleeding. | ||
==History== | ==History== | ||
* When evaluating a patient for chronic lymphocytic leukemia, a clinician should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history are outlined below: | * When evaluating a patient for chronic lymphocytic leukemia, a clinician should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history are outlined below: | ||
Revision as of 00:30, 7 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]Raviteja Guddeti, M.B.B.S. [3]
Overview
25-50% patients of chronic lymphocytic leukemia are usually asymptomatic with incidental absolute lymphocytosis finding on a routine blood examination. The onset of chronic lymphocytic leukemia is insidious and can present with wide range of symptoms. Symptoms of chronic lymphocytic leukemia include lymph node swelling and B symptoms including fever, weight loss, night sweats, fatigue and recurrent bleeding.
History
- When evaluating a patient for chronic lymphocytic leukemia, a clinician should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history are outlined below:
- Review family history for members with positive history of the disease
- Review occupational history related to farming
- Review any exposure to herbicides or insecticides
Symptoms
- Symptoms of chronic lymphocytic leukemia include:[1]
- Painless lymph node enlargement (50-90%)
- Splenomegaly (25 -55%)
- Hepatomegaly (15-25%)
- B sypmtpms (5-10%):[1]
- Fever
- Unintentional weight loss
- Muscle wasting
- Generalized weakness/ Fatigue
- Anorexia
- Night sweats
- Recurrent infections
- Recurrent bleeding
- Skin lesions (leukemia cutis)
References
- ↑ 1.0 1.1 Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O'Brien S, Robak T, Seymour JF, Kipps TJ (June 2018). "iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL". Blood. 131 (25): 2745–2760. doi:10.1182/blood-2017-09-806398. PMID 29540348.