Appendix cancer differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2]

Overview

appendix cancer must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

appendix cancer must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].

Differentiating appendix cancer from other Diseases

appendix cancer must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

appendix cancer must be differentiated from [differential dx1], [differential dx2], and [differential dx3].

OR

As appendix cancer manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].

Differentiating appendix cancer from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]

On the basis [symptom 1], [symptom 2], and [symptom 3], appendix cancer must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

Diseases		Clinical manifestations													Para-clinical findings								Gold standard	Additional findings
		Symptoms								Physical examination
															Lab Findings			Imaging				Histopathology
		Abdominal pain	Change in girdle size	Change in bowel habits		Flushing	Palpitation	Dyspnea	Other symptoms	Abdominal mass	abdominal tenderness	Wheezing	Tricuspid regurgitation murmur		Urinary 5-hydroxyindoleacetic acid (5-HIAA)	Serum Chromogranin A (CgA)	Other lab findings	CT scan	MRI	Utrasounography	Other imaging modalities
				Diarrhea	Constipation
Appendix cancer	Adenocarcinoma
	Carcinoid tumor	+/-	-	+	-	+	+	+		-	-	+	+		+	+
Mucocele
Ovarian tumor
Pseudomyxoma peritonei
Carcinoid syndrome
Appendicitis		LLQ / RRQ	-	-/+ Intermittent Secretory type	+	-	-/+ Tachycardia is prevalent	-	Nausea & vomiting,decreased appetite Anorexia	+/-	+	-	-	Rebound tenderness Abdominal guarding Rovsing's sign Psoas sign Obturator sign ,	-	-	Leukocytosis Left shift	Appendiceal wall thickening /perforation peri-appendiceal inflammation, fluid accumulation,fat stranding	Increased fluid signal on T2 weighted sequence	Evidences of inflammation	Tc-99m labeled anti-CD15 antibodies	Evidences of inflammation	CT scan	Alvarado Score
	Diseases	Symptom 1	Symptom 2	Symptom 3						Physical exam 1	Physical exam 2	Physical exam 3			Lab 1	Lab 2	Lab 3	Imaging 1	Imaging 2		Imaging 3	Histopathology	Gold standard	Additional findings
	Differential Diagnosis 4
	Differential Diagnosis 5
	Differential Diagnosis 6