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Revision as of 16:18, 11 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: , Gertrude Djouka, M.D.[2]

Differential diagnosis of neck masses==

Differential diagnosis of neck masses include:

Category	Diseases		Benign or Malignant	Clinical manifestation								Paraclinical findings			Gold standard diagnosis	Associated findings
				Demography	History	Symptoms		Signs				Lab findings	Histopathology	Imaging
				Demography	History	Pain	Dysphagia	Mass exam	Skin changes	LAP	Others	Lab findings	Histopathology	Imaging
Congenital	Branchial cleft cyst		Benign
	Thyroglossal duct cyst
	Hemangioma
	Vascular malformations
	Lymphatic malformations
	Laryngocele
	Ranula
	Teratoma
	Dermoid cyst
	Thymic cyst
Category	Diseases		Benign or Malignant	Demography	History	Pain	Dysphagia	Mass exam	Skin changes	LAP	Others	Lab findings	Histopathology	Imaging	Gold standard diagnosis	Associated findings
Inflammatory	Acute sialadenitis
	Chronic sialadenitis
	Reactive viral lymphadenopathy	CMV
		EBV
		HIV
		Viral URI
	Bacterial lymphadenopathy	Tularemia
		Brucellosis
		Cat-scratch disease^[1]^[2]	Benign	More common in the Southern of U.S among children and young adults.	Cat exposure Fever Fatigue Headache	+	-	Tender cervical nodes	Vesicular Erythema Papule at site of inoculation	+		↑ ESR Serology: + antibody to Bartonella Henselae	Satellite micro-abscess with granuloma	-	-	Bacillary Angiomatosis Bacillary Peliosis
		Actinomycosis^[3]^[4]	Benign	No predilection in race, age Male to female ratio : 1.5 to 3:1	History of dental procedure or trauma Poor oral hygiene Swelling mandible	-	-	Tender at the beginning Painless Fluctuant Non-tender at late stage	Red Blue	-		↑ ESR ↑ CRP Gram stains: Gram positive filamentous rods	Sulfur granules Filamentous organism	-	Histological examination Bacterial culture of the abscess	Mandible osteomyelitis
		Mycobacterial infections^[5]^[6]^[7]	Benign	More common in adults and children in endemic continent such as Africa	Recent travel to endemic regions Exposure to TB patients	-	-	Matted cervical nodes Firm Non-tender	Indurated	+		PPD: + Sputum smear: Presence of acid fast bacilli	Chronic necrotizing caseating calcified granuloma	Neck Ultrasound: Multiple lymph nodes Fusion tendency Internal echoes	Culture for mycobacteria	-
		Streptococcal infection^[8]^[9]	Benign	More common in children and adolescents	Fever Absence of cough Difficulty swallowing Swollen pharynx	+	+	Tender anterior cervical nodes Tonsillar exudates	-	+		Rapid antigen detection tests: +/-	Follicular hyperplasia Infiltration of polymorphonuclear cells	-	Throat culture	Acute rheumatic fever Post-streptoccocal glomerulonephritis
	Parasitic lymphadenopathy	Toxoplasma gondii^[10]^[11]	Benign	6 years old and older adults are more affected in U.S. Seen in Hot climates	Cats or birds feces exposure Drinking unpasteurized milk Undercooked food Organ transplant recipients	+	-	Bilateral Non-tender Symmetrical Non-fluctuant	-	+		Serology : + IgG and IgM antibodies	Follicular hyperplasia	MRI: Multiple rings enhanced lesions	Serology Immunofluorescence MRI CT scan	-
	Sarcoidosis^[12]^[13]		Benign	More common in African American women aged 20 - 40 years.	Family history of sarcoidosis Fatigue Swelling and pain in the joints	-	-	Bilateral tender lymph nodes Swollen Non-tender parotid glands	Erythema nodosum Lupus pernios	+		↑ ESR ↑ ACE	Non-necrotizing epithelioid granuloma	CXR: B/L hilar adenopathy MRI: B/L multiples enlarged cervical lymph nodes	Biopsy	Heerfordt's syndrome: uveitis, facial nerve paralysis, parotitis
	Sjögren syndrome^[14]		Benign	Female to male ratio: 9 to 1 May happen at any age Mean age: 40-50	History of RA, SLE, and non-hodgkin B-cell lymphoma. Dry mouth, dry eyes.	-	+	Firm, B/L enlarged parotid glands	Pruritis Rashes Dry	+		↑ ESR Anti-SSA/Ro: + Anti-SSB/La: + Cytopenia Wetting <5 mm on Schirmer's test	Hyperactivity of B cells and lymphocytes which lead to infiltration of the exocrine glands.	US: Hypoechoic and inhomogeneous salivary glands	Biopsy	-
	Castleman disease (angiofollicular lymphoproliferative disease)^[15]^[16]		Benign	Mean age: 30-40 years	Asymptomatic at early onset B-symptoms	-	-	Non tender cervical node	Papule Cherry hemangiomata	+		↑ ESR ↑ CRP Anemia Polyclonal hypergammaglobulinemia	Hyaline vascular variant Plasma cell variant Mixed variant	CT scan of thorax Matted lymphadenopathy Solitary, noninvasive mass	Biopsy	HHSV-8 Kaposi Sarcoma Non-hodgkin lymphoma POEMS syndrome
	Kikuchi disease (histiocytic necrotizing lymphadenitis)^[17]		Benign	High prevalence in Japan More common in young adults <30 years old	Fever Flu-like prodrome	+	-	Tender cervical nodes	rashes	+		↑ ESR Abnormal liver enzymes leucopenia	Irregular paracortical areas of coagulative necrosis with abundant karyorrhectic debris	-	Biopsy	Hashimoto thyroiditis
	Kimura disease^[18]		Benign	More common in Asian males.	History of painless cervical lump	-	-	Large Non-tender cervical node	Itching	+		↑ Eosinophils	Conserved lymph node structure Eosinophilic infiltration High postcapillary venules	-	Biopsy	Nephrotic syndrom Hypercoaguble state
	Rosai-Dorfman disease^[19]^[20]		Benign	More common in children	Fever	-	-	Non-tender enlarged cervical lymph nodes	Erythema	+		↑ ESR Polyclonal hypergammaglobulinemia	-	-	-	-
	Kawasaki disease^[21]^[22]		Benign	More common in children younger than 5 years old. Highest incidence in Japan. Most leading cause of acquired heart disease in U.S.	High fever B/L conjunctivitis Rash Swelling of hands and feet Inflammation of lips Strawberry tongue	-	-	Large, single palpable cervical node	Rashes Desquamation of skin	+		↑ ESR ↑ CRP	Inflammation of medium sized arteries and organs.	Echocardiography: Coronary artery dilation Coronary artery aneurysm	Clinical findings
	Category	Diseases		Benign or Malignant	Demography	History	Pain	Dysphagia	Mass exam	Skin changes	LAP	Others	Lab findings	Histopathology	Imaging	Gold standard diagnosis	Associated findings
Neoplasm	Hypopharyngeal cancer^[23]^[24]^[25]		Malignant	More common in males Age: 55-65 years old Incidence: < 1/100,000 in U.S. More common: Japan, India, Iran	Tobacco use Abuse alcohol consumption HPV infection Lump in the neck Odynophagia Hoarseness	-	+	Non tender cervical node	-	+		-	Spindle cells Nuclear atypia Basaloid cells Abundant chromatin	Neck CT scan: Soft tissue mass Irregular thickening of mucosa Necrotic region MRI: Tumors are hypointense on T1 and hyperintense on T2	Biopsy	-
	Salivary gland neoplasm	Pleomorphic adenoma^[26]	Benign	More common in Females Incidence increase with age. Incidence : 2-3.5 cases per 100,000 population	History of swelling Dysphagia Hoarseness	-	+	Palpable mass of deep lobe of parotid gland Firm Mobile	-	-		-	Proliferation of epithelial cells and stromal matrix in the ducts.	MRI:^[27] Homogenous on T1 Abundant myxochondroid stroma on T2	Biopsy	-
		Warthin's tumor^[28]^[29]	Benign	Male to Female ratio : 4:1 More common in people aged 60 to 70 years old.	History of swollen salivary gland Jaw pain Tinnitus	-	+	Non tender Mobile Firm Solitary	-	-		-	Papillae Fibrous capsule Cystic spaces	Neck CT: Cystic lesion posteriorly within the parotid gland. MRI: B/L lesions Heterogeneous	Biopsy
		Oncocytoma
		Monomorphic adenoma
		Mucoepidermoid carcinoma
		Adenoid cystic carcinoma
		Adenocarcinoma
		Salivary duct carcinoma
		Squamous cell carcinoma
		Parathyroid tumors
	Carotid body tumors
	Paraganglioma
	Schwannoma
	Lymphoma
	Liposarcoma
	Lipoma
	Glomus vagale, glomus jugulare tumors
	Nasopharyngeal cancer
	Other	Hematoma
Arteriovenous fistula
Goiter
Category		Diseases		Benign	Demography	History	Pain	Dysphagia	Mass exam	Skin changes	LAP	Others	Lab findings	Histopathology	Imaging	Gold standard diagnosis	Associated findings

References

↑ "Cat-Scratch Disease in the United States, 2005–2013 - Volume 22, Number 10—October 2016 - Emerging Infectious Diseases journal - CDC".
↑ Hansmann, Y.; DeMartino, S.; Piemont, Y.; Meyer, N.; Mariet, P.; Heller, R.; Christmann, D.; Jaulhac, B. (2005). "Diagnosis of Cat Scratch Disease with Detection of Bartonella henselae by PCR: a Study of Patients with Lymph Node Enlargement". Journal of Clinical Microbiology. 43 (8): 3800–3806. doi:10.1128/JCM.43.8.3800-3806.2005. ISSN 0095-1137.
↑ Valour F, Sénéchal A, Dupieux C, Karsenty J, Lustig S, Breton P, Gleizal A, Boussel L, Laurent F, Braun E, Chidiac C, Ader F, Ferry T (2014). "Actinomycosis: etiology, clinical features, diagnosis, treatment, and management". Infect Drug Resist. 7: 183–97. doi:10.2147/IDR.S39601. PMC 4094581. PMID 25045274.
↑ Bonnefond S, Catroux M, Melenotte C, Karkowski L, Rolland L, Trouillier S, Raffray L (June 2016). "Clinical features of actinomycosis: A retrospective, multicenter study of 28 cases of miscellaneous presentations". Medicine (Baltimore). 95 (24): e3923. doi:10.1097/MD.0000000000003923. PMC 4998488. PMID 27311002.
↑ Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A (March 2014). "Peripheral lymphadenopathy: approach and diagnostic tools". Iran J Med Sci. 39 (2 Suppl): 158–70. PMC 3993046. PMID 24753638.
↑ Suskind DL, Handler SD, Tom LW, Potsic WP, Wetmore RF (July 1997). "Nontuberculous mycobacterial cervical adenitis". Clin Pediatr (Phila). 36 (7): 403–9. doi:10.1177/000992289703600705. PMID 9241478.
↑ Drobniewski FA, Caws M, Gibson A, Young D (March 2003). "Modern laboratory diagnosis of tuberculosis". Lancet Infect Dis. 3 (3): 141–7. PMID 12614730.
↑ Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A (March 2014). "Peripheral lymphadenopathy: approach and diagnostic tools". Iran J Med Sci. 39 (2 Suppl): 158–70. PMC 3993046. PMID 24753638.
↑ Kenealy T (November 2007). "Sore throat". BMJ Clin Evid. 2007. PMC 2943825. PMID 19450346.
↑ Kumar GG, Mahadevan A, Guruprasad AS, Kovoor JM, Satishchandra P, Nath A, Ranga U, Shankar SK (June 2010). "Eccentric target sign in cerebral toxoplasmosis: neuropathological correlate to the imaging feature". J Magn Reson Imaging. 31 (6): 1469–72. doi:10.1002/jmri.22192. PMC 2908244. PMID 20512900.
↑ [+https://www.cdc.gov/parasites/toxoplasmosis/diagnosis.html "CDC - Toxoplasmosis - Diagnosis"] Check |url= value (help).
↑ "Sarcoidosis | National Heart, Lung, and Blood Institute (NHLBI)".
↑ Abdel Razek A, Mukherji S (June 2017). "Imaging of sialadenitis". Neuroradiol J. 30 (3): 205–215. doi:10.1177/1971400916682752. PMC 5480791. PMID 28059621. Vancouver style error: initials (help)
↑ Mavragani CP, Moutsopoulos HM (October 2014). "Sjögren syndrome". CMAJ. 186 (15): E579–86. doi:10.1503/cmaj.122037. PMC 4203623. PMID 24566651.
↑ Dispenzieri A, Armitage JO, Loe MJ, Geyer SM, Allred J, Camoriano JK, Menke DM, Weisenburger DD, Ristow K, Dogan A, Habermann TM (November 2012). "The clinical spectrum of Castleman's disease". Am. J. Hematol. 87 (11): 997–1002. doi:10.1002/ajh.23291. PMC 3900496. PMID 22791417.
↑ Saeed-Abdul-Rahman I, Al-Amri AM (September 2012). "Castleman disease". Korean J Hematol. 47 (3): 163–77. doi:10.5045/kjh.2012.47.3.163. PMC 3464333. PMID 23071471.
↑ Bosch X, Guilabert A (May 2006). "Kikuchi-Fujimoto disease". Orphanet J Rare Dis. 1: 18. doi:10.1186/1750-1172-1-18. PMC 1481509. PMID 16722618.
↑ AlGhamdi FE, Al-Khatib TA, Marzouki HZ, AlGarni MA (March 2016). "Kimura disease: No age or ethnicity limit". Saudi Med J. 37 (3): 315–9. doi:10.15537/smj.2016.3.14448. PMC 4800898. PMID 26905356.
↑ "Rosai-Dorfman disease | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".
↑ Foucar E, Rosai J, Dorfman R (February 1990). "Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity". Semin Diagn Pathol. 7 (1): 19–73. PMID 2180012.
↑ "About Kawasaki Disease | Kawasaki Disease | CDC".
↑ "Kawasaki Disease | National Heart, Lung, and Blood Institute (NHLBI)".
↑ Helliwell TR (February 2003). "acp Best Practice No 169. Evidence based pathology: squamous carcinoma of the hypopharynx". J. Clin. Pathol. 56 (2): 81–5. PMC 1769882. PMID 12560383.
↑ International Journal of Recent Scientific Research. doi:10.24327/IJRSR. ISSN 0976-3031. Missing or empty |title= (help)
↑ Maasland, Denise HE; van den Brandt, Piet A; Kremer, Bernd; Goldbohm, R Alexandra; Schouten, Leo J (2014). "Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study". BMC Cancer. 14 (1). doi:10.1186/1471-2407-14-187. ISSN 1471-2407.
↑ Debnath SC, Adhyapok AK (June 2010). "Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip". J Maxillofac Oral Surg. 9 (2): 205–8. doi:10.1007/s12663-010-0052-5. PMC 3244097. PMID 22190789.
↑ Kato H, Kawaguchi M, Ando T, Mizuta K, Aoki M, Matsuo M (August 2018). "Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features". Jpn J Radiol. 36 (8): 463–471. doi:10.1007/s11604-018-0747-y. PMID 29845358.
↑ Chulam TC, Noronha Francisco AL, Goncalves Filho J, Pinto Alves CA, Kowalski LP (December 2013). "Warthin's tumour of the parotid gland: our experience". Acta Otorhinolaryngol Ital. 33 (6): 393–7. PMID 24376295.
↑ "Warthin tumor | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".

[urlCat-Scratch_Disease_in_the_United_States,_2005–2013_-_Volume_22,_Number_10—October_2016_-_Emerging_Infectious_Diseases_journal_-_CDC-1] "Cat-Scratch Disease in the United States, 2005–2013 - Volume 22, Number 10—October 2016 - Emerging Infectious Diseases journal - CDC".

[HansmannDeMartino2005-2] Hansmann, Y.; DeMartino, S.; Piemont, Y.; Meyer, N.; Mariet, P.; Heller, R.; Christmann, D.; Jaulhac, B. (2005). "Diagnosis of Cat Scratch Disease with Detection of Bartonella henselae by PCR: a Study of Patients with Lymph Node Enlargement". Journal of Clinical Microbiology. 43 (8): 3800–3806. doi:10.1128/JCM.43.8.3800-3806.2005. ISSN 0095-1137.

[pmid25045274-3] Valour F, Sénéchal A, Dupieux C, Karsenty J, Lustig S, Breton P, Gleizal A, Boussel L, Laurent F, Braun E, Chidiac C, Ader F, Ferry T (2014). "Actinomycosis: etiology, clinical features, diagnosis, treatment, and management". Infect Drug Resist. 7: 183–97. doi:10.2147/IDR.S39601. PMC 4094581. PMID 25045274.

[pmid27311002-4] Bonnefond S, Catroux M, Melenotte C, Karkowski L, Rolland L, Trouillier S, Raffray L (June 2016). "Clinical features of actinomycosis: A retrospective, multicenter study of 28 cases of miscellaneous presentations". Medicine (Baltimore). 95 (24): e3923. doi:10.1097/MD.0000000000003923. PMC 4998488. PMID 27311002.

[pmid24753638-5] Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A (March 2014). "Peripheral lymphadenopathy: approach and diagnostic tools". Iran J Med Sci. 39 (2 Suppl): 158–70. PMC 3993046. PMID 24753638.

[pmid9241478-6] Suskind DL, Handler SD, Tom LW, Potsic WP, Wetmore RF (July 1997). "Nontuberculous mycobacterial cervical adenitis". Clin Pediatr (Phila). 36 (7): 403–9. doi:10.1177/000992289703600705. PMID 9241478.

[pmid12614730-7] Drobniewski FA, Caws M, Gibson A, Young D (March 2003). "Modern laboratory diagnosis of tuberculosis". Lancet Infect Dis. 3 (3): 141–7. PMID 12614730.

[pmid247536382-8] Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A (March 2014). "Peripheral lymphadenopathy: approach and diagnostic tools". Iran J Med Sci. 39 (2 Suppl): 158–70. PMC 3993046. PMID 24753638.

[pmid19450346-9] Kenealy T (November 2007). "Sore throat". BMJ Clin Evid. 2007. PMC 2943825. PMID 19450346.

[pmid20512900-10] Kumar GG, Mahadevan A, Guruprasad AS, Kovoor JM, Satishchandra P, Nath A, Ranga U, Shankar SK (June 2010). "Eccentric target sign in cerebral toxoplasmosis: neuropathological correlate to the imaging feature". J Magn Reson Imaging. 31 (6): 1469–72. doi:10.1002/jmri.22192. PMC 2908244. PMID 20512900.

[urlCDC_-_Toxoplasmosis_-_Diagnosis-11] [+https://www.cdc.gov/parasites/toxoplasmosis/diagnosis.html "CDC - Toxoplasmosis - Diagnosis"] Check |url= value (help).

[urlSarcoidosis_|_National_Heart,_Lung,_and_Blood_Institute_(NHLBI)-12] "Sarcoidosis | National Heart, Lung, and Blood Institute (NHLBI)".

[pmid28059621-13] Abdel Razek A, Mukherji S (June 2017). "Imaging of sialadenitis". Neuroradiol J. 30 (3): 205–215. doi:10.1177/1971400916682752. PMC 5480791. PMID 28059621. Vancouver style error: initials (help)

[pmid24566651-14] Mavragani CP, Moutsopoulos HM (October 2014). "Sjögren syndrome". CMAJ. 186 (15): E579–86. doi:10.1503/cmaj.122037. PMC 4203623. PMID 24566651.

[pmid22791417-15] Dispenzieri A, Armitage JO, Loe MJ, Geyer SM, Allred J, Camoriano JK, Menke DM, Weisenburger DD, Ristow K, Dogan A, Habermann TM (November 2012). "The clinical spectrum of Castleman's disease". Am. J. Hematol. 87 (11): 997–1002. doi:10.1002/ajh.23291. PMC 3900496. PMID 22791417.

[pmid23071471-16] Saeed-Abdul-Rahman I, Al-Amri AM (September 2012). "Castleman disease". Korean J Hematol. 47 (3): 163–77. doi:10.5045/kjh.2012.47.3.163. PMC 3464333. PMID 23071471.

[pmid16722618-17] Bosch X, Guilabert A (May 2006). "Kikuchi-Fujimoto disease". Orphanet J Rare Dis. 1: 18. doi:10.1186/1750-1172-1-18. PMC 1481509. PMID 16722618.

[pmid26905356-18] AlGhamdi FE, Al-Khatib TA, Marzouki HZ, AlGarni MA (March 2016). "Kimura disease: No age or ethnicity limit". Saudi Med J. 37 (3): 315–9. doi:10.15537/smj.2016.3.14448. PMC 4800898. PMID 26905356.

[urlRosai-Dorfman_disease_|_Genetic_and_Rare_Diseases_Information_Center_(GARD)_–_an_NCATS_Program-19] "Rosai-Dorfman disease | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".

[pmid2180012-20] Foucar E, Rosai J, Dorfman R (February 1990). "Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity". Semin Diagn Pathol. 7 (1): 19–73. PMID 2180012.

[urlAbout_Kawasaki_Disease_|_Kawasaki_Disease_|_CDC-21] "About Kawasaki Disease | Kawasaki Disease | CDC".

[urlKawasaki_Disease_|_National_Heart,_Lung,_and_Blood_Institute_(NHLBI)-22] "Kawasaki Disease | National Heart, Lung, and Blood Institute (NHLBI)".

[pmid12560383-23] Helliwell TR (February 2003). "acp Best Practice No 169. Evidence based pathology: squamous carcinoma of the hypopharynx". J. Clin. Pathol. 56 (2): 81–5. PMC 1769882. PMID 12560383.

[24] International Journal of Recent Scientific Research. doi:10.24327/IJRSR. ISSN 0976-3031. Missing or empty |title= (help)

[Maaslandvan_den_Brandt2014-25] Maasland, Denise HE; van den Brandt, Piet A; Kremer, Bernd; Goldbohm, R Alexandra; Schouten, Leo J (2014). "Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study". BMC Cancer. 14 (1). doi:10.1186/1471-2407-14-187. ISSN 1471-2407.

[pmid22190789-26] Debnath SC, Adhyapok AK (June 2010). "Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip". J Maxillofac Oral Surg. 9 (2): 205–8. doi:10.1007/s12663-010-0052-5. PMC 3244097. PMID 22190789.

[pmid29845358-27] Kato H, Kawaguchi M, Ando T, Mizuta K, Aoki M, Matsuo M (August 2018). "Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features". Jpn J Radiol. 36 (8): 463–471. doi:10.1007/s11604-018-0747-y. PMID 29845358.

[pmid24376295-28] Chulam TC, Noronha Francisco AL, Goncalves Filho J, Pinto Alves CA, Kowalski LP (December 2013). "Warthin's tumour of the parotid gland: our experience". Acta Otorhinolaryngol Ital. 33 (6): 393–7. PMID 24376295.

[urlWarthin_tumor_|_Genetic_and_Rare_Diseases_Information_Center_(GARD)_–_an_NCATS_Program-29] "Warthin tumor | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".

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@@ Line 485: / Line 485: @@
 * Rapid antigen detection tests: +/-
 | align="center" style="background:#F5F5F5;" |
-* Follicular hyperplasia
+* Follicular [[hyperplasia]]
-* Infiltration of polymorphonuclear cells
+* [[Infiltration (medical)|Infiltration]] of [[Polymorphonuclear cells|polymorphonuclear]] [[cells]]
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" |
@@ Line 527: / Line 527: @@
 | align="center" style="background:#F5F5F5;" |
 * [[Serology]] :
-+ IgG and IgM
++ [[IgG]] and [[IgM]] [[antibodies]]
-antibodies
 | align="center" style="background:#F5F5F5;" |
-* Follicular hyperplasia
+* Follicular [[hyperplasia]]
 | align="center" style="background:#F5F5F5;" |[[MRI]]:
-* Multiple rings enhanced lesions
+* Multiple rings enhanced [[lesions]]
 | align="center" style="background:#F5F5F5;" |
 * [[Serology]]
@@ Line 647: / Line 646: @@
 * ↑ [[CRP]]
 * [[Anemia]]
-* Polyclonal [[hypergammaglobulinemia]]
+* [[Polyclonal]] [[hypergammaglobulinemia]]
 | align="center" style="background:#F5F5F5;" |
 * [[Hyaline]] [[vascular]] variant
@@ Line 660: / Line 659: @@
 * HHSV-8
 * Kaposi Sarcoma
-* Non-hodgkin lymphoma
+* [[Non-Hodgkin lymphoma|Non-hodgkin lymphoma]]
-* POEMS syndrome
+* [[POEMS syndrome]]
 |-
 ! colspan="2" align="center" style="background:#DCDCDC;" |[[Kikuchi disease]] ([[histiocytic necrotizing lymphadenitis]])<ref name="pmid16722618">{{cite journal |vauthors=Bosch X, Guilabert A |title=Kikuchi-Fujimoto disease |journal=Orphanet J Rare Dis |volume=1 |issue= |pages=18 |date=May 2006 |pmid=16722618 |pmc=1481509 |doi=10.1186/1750-1172-1-18 |url=}}</ref>
@@ Line 695: / Line 694: @@
 * [[Biopsy]]
 | align="center" style="background:#F5F5F5;" |
-* Hashimoto thyroiditis
+* Hashimoto [[thyroiditis]]
 |-
 ! colspan="2" align="center" style="background:#DCDCDC;" |[[Kimura disease]]<ref name="pmid26905356">{{cite journal |vauthors=AlGhamdi FE, Al-Khatib TA, Marzouki HZ, AlGarni MA |title=Kimura disease: No age or ethnicity limit |journal=Saudi Med J |volume=37 |issue=3 |pages=315–9 |date=March 2016 |pmid=26905356 |pmc=4800898 |doi=10.15537/smj.2016.3.14448 |url=}}</ref>
@@ Line 703: / Line 702: @@
 * More common in Asian males.
 | align="center" style="background:#F5F5F5;" |
-* History of painless cervical lump
+* History of painless [[cervical]] lump
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" | -
@@ Line 709: / Line 708: @@
 * Large
-* Non-tender cervical node
+* Non-tender [[Cervical|cervical node]]
 | align="center" style="background:#F5F5F5;" |
-* Itching
+* [[Itching]]
 | align="center" style="background:#F5F5F5;" | +
 | align="center" style="background:#F5F5F5;" |
-| align="center" style="background:#F5F5F5;" |↑ eosinophils
+| align="center" style="background:#F5F5F5;" |↑ [[Eosinophils]]
 | align="center" style="background:#F5F5F5;" |
-* Conserved lymph node structure
+* Conserved [[Lymph nodes|lymph node]] structure
-* Eosinophilic infiltration
+* [[Eosinophilic]] infiltration
-* High postcapillary venules
+* High [[Capillary|postcapillary]] venules
 | align="center" style="background:#F5F5F5;" | -
@@ Line 734: / Line 733: @@
 * [[Benign]]
 | align="center" style="background:#F5F5F5;" |
-* More common in children
+* More common in [[children]]
 | align="center" style="background:#F5F5F5;" |
-* Fever
+* [[Fever]]
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" |
-* Non-tender enlarged cervical lymph nodes
+* Non-tender enlarged [[cervical lymph nodes]]
 | align="center" style="background:#F5F5F5;" |
-* Erythema
+* [[Erythema]]
 | align="center" style="background:#F5F5F5;" | +
 | align="center" style="background:#F5F5F5;" |
 | align="center" style="background:#F5F5F5;" |
-* ↑ ESR
+* ↑ [[ESR]]
-* Polyclonal hypergammaglobulinemia
+* [[Polyclonal]] [[hypergammaglobulinemia]]
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" | -
@@ Line 761: / Line 760: @@
 * More common in children younger than 5 years old.
-* Highest incidence in Japan.
+* Highest [[incidence]] in Japan.
-* Most leading cause of acquired heart disease in U.S.
+* Most leading cause of acquired [[heart disease]] in U.S.
 | align="center" style="background:#F5F5F5;" |
-* High fever
+* High [[fever]]
-* B/L conjunctivitis
+* B/L [[conjunctivitis]]
-* Rash
+* [[Rash]]
-* Swelling of hands and feet
+* [[Swelling]] of hands and feet
-* Inflammation of lips
+* Inflammation of [[lips]]
-* Strawberry tongue
+* [[Strawberry tongue]]
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" |
-* Large, single palpable cervical node
+* Large, single palpable [[Cervical|cervical node]]
 | align="center" style="background:#F5F5F5;" |
-* Rashes
+* [[Rashes]]
-* Desquamation of skin
+* [[Desquamation]] of skin
 | align="center" style="background:#F5F5F5;" | +
 | align="center" style="background:#F5F5F5;" |
 | align="center" style="background:#F5F5F5;" |
-* ↑ ESR
+* ↑ [[ESR]]
-* ↑ CRP
+* ↑ [[CRP]]
 | align="center" style="background:#F5F5F5;" |
-* Inflammation of medium sized arteries and organs.
+* [[Inflammation]] of medium sized [[arteries]] and [[organs]].
-| align="center" style="background:#F5F5F5;" | Echocardiography:
+| align="center" style="background:#F5F5F5;" | [[Echocardiography]]:
-* Coronary artery
+* [[Coronary artery]]
-dilation
+[[dilation]]
-* Coronary artery aneurysm
+* [[Coronary artery]] [[aneurysm]]
 | align="center" style="background:#F5F5F5;" |
@@ Line 826: / Line 825: @@
 | align="center" style="background:#F5F5F5;" |
 * More common in males
-* Age: 55-65 years old
+* [[Age]]: 55-65 years old
-* Incidence: < 1/100,000 in U.S.
+* [[Incidence]]: < 1/100,000 in U.S.
 * More common: Japan, India, Iran
 | align="center" style="background:#F5F5F5;" |
-* Tobacco use
+* [[Tobacco]] use
-* Abuse alcohol consumption
+* [[Abuse|Abuse alcohol]] consumption
-* HPV infection
+* [[HPV infection]]
-* Lump in the neck
+* Lump in the [[neck]]
-* Odynophagia
+* [[Odynophagia]]
-* Hoarseness
+* [[Hoarseness]]
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" | +
 | align="center" style="background:#F5F5F5;" |
-* Non tender cervical node
+* Non tender [[Cervical|cervical node]]
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" | +
@@ Line 845: / Line 844: @@
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" |
-* Spindle cells
+* [[Spindle cells]]
-* Nuclear atypia
+* [[Nuclear|Nuclear atypia]]
-* Basaloid cells
+* Basaloid [[cells]]
-* Abundant chromatin
+* Abundant [[chromatin]]
-| align="center" style="background:#F5F5F5;" | Neck CT scan:
+| align="center" style="background:#F5F5F5;" | [[Neck]] [[CT]] scan:
-* Soft tissue mass
+* [[Soft tissue]] mass
-* Irregular thickening of mucosa
+* Irregular thickening of [[mucosa]]
-* Necrotic region
+* [[Necrotic|Necrotic region]]
-MRI:
+[[MRI]]:
-* Tumors are hypointense on T1 and hyperintense on T2
+* [[Tumors]] are hypointense on T1 and hyperintense on T2
 | align="center" style="background:#F5F5F5;" |
 * [[Biopsy]]
@@ Line 867: / Line 866: @@
 * More common in Females
-* Incidence increase with age.
+* [[Incidence]] increase with [[age]].
-* Incidence : 2-3.5 cases per 100,000 population
+* [[Incidence]] : 2-3.5 cases per 100,000 [[population]]
 | align="center" style="background:#F5F5F5;" |
-* History of swelling
+* History of [[swelling]]
-* Dysphagia
+* [[Dysphagia]]
-* Hoarseness
+* [[Hoarseness]]
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" | +
 | align="center" style="background:#F5F5F5;" |
-* Palpable mass of deep lobe of parotid gland
+* Palpable [[mass]] of deep [[lobe]] of [[parotid gland]]
 * Firm
@@ Line 890: / Line 889: @@
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" |
-* Proliferation of epithelial cells and stromal matrix in the ducts.
+* Proliferation of [[epithelial cells]] and [[stromal]] [[matrix]] in the [[ducts]].
 | align="center" style="background:#F5F5F5;" |
-* MRI:<ref name="pmid29845358">{{cite journal |vauthors=Kato H, Kawaguchi M, Ando T, Mizuta K, Aoki M, Matsuo M |title=Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features |journal=Jpn J Radiol |volume=36 |issue=8 |pages=463–471 |date=August 2018 |pmid=29845358 |doi=10.1007/s11604-018-0747-y |url=}}</ref> Homogenous on T1
+* [[MRI]]:<ref name="pmid29845358">{{cite journal |vauthors=Kato H, Kawaguchi M, Ando T, Mizuta K, Aoki M, Matsuo M |title=Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features |journal=Jpn J Radiol |volume=36 |issue=8 |pages=463–471 |date=August 2018 |pmid=29845358 |doi=10.1007/s11604-018-0747-y |url=}}</ref> Homogenous on T1
-* Abundant myxochondroid stroma on T2
+* Abundant myxochondroid [[stroma]] on T2
 | align="center" style="background:#F5F5F5;" |
 * [[Biopsy]]
@@ Line 907: / Line 906: @@
 * More common in people aged 60 to 70 years old.
 | align="center" style="background:#F5F5F5;" |
-* History of swollen salivary gland
+* History of [[Swelling|swollen]] [[salivary gland]]
-* Jaw pain
+* [[Jaw]] pain
-* Tinnitus
+* [[Tinnitus]]
 | align="center" style="background:#F5F5F5;" | -
@@ Line 922: / Line 921: @@
 * Firm
-* Solitary
+* [[Solitary]]
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" | -
@@ Line 928: / Line 927: @@
 | align="center" style="background:#F5F5F5;" | -
 | align="center" style="background:#F5F5F5;" |
-* Papillae
+* [[Papillae]]
-* Fibrous capsule
+* [[Fibrous]] [[capsule]]
-* Cystic spaces
+* [[Cystic]] spaces
-| align="center" style="background:#F5F5F5;" | Neck CT:
+| align="center" style="background:#F5F5F5;" | [[CT|Neck CT]]:
-* Cystic lesion posteriorly within the parotid gland.
+* [[Cystic]] lesion posteriorly within the [[parotid gland]].
-MRI:
+[[MRI]]:
 * B/L lesions
 Heterogeneous

Sandbox: Gertrude: Difference between revisions

Revision as of 16:18, 11 February 2019

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