Craniopharyngioma natural history, complication and prognosis: Difference between revisions
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==Prognosis== | ==Prognosis== | ||
* Craniopharyngioma is a [[benign]] tumor, the 5-year and 10-year survival rates, regardless of treatment given, are higher than 90%. <ref>Prognosis of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc</ref> | |||
* Patients can have a permanent cure if the tumor can be completely removed with [[surgery]] or treated with high doses of [[radiation]].<ref>Prognosis. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm</ref> | |||
*The neurological deficits and hormonal imbalances caused by the tumor and the treatment | * The outlook depends on whether or not the tumor can be removed by surgery. | ||
*The neurological deficits and hormonal imbalances caused by the tumor and the treatment The patient’s general health | |||
Recent research<ref name="ReferenceA">{{cite journal|last1=Sofela|first1=AA|last2=Hettige|first2=S|last3=Curran|first3=O|last4=Bassi|first4=S|title=Malignant transformation in craniopharyngiomas.|journal=Neurosurgery|date=Sep 2014|volume=75|issue=3|pages=306–14; discussion 314|pmid=24978859|doi=10.1227/NEU.0000000000000380}}</ref> | * Recent research has demonstrated [[malignant]] tendency of craniopharyngiomas. | ||
* These malignant craniopharyngiomas are very rare, but are associated with poor prognosis.<ref name="ReferenceA">{{cite journal|last1=Sofela|first1=AA|last2=Hettige|first2=S|last3=Curran|first3=O|last4=Bassi|first4=S|title=Malignant transformation in craniopharyngiomas.|journal=Neurosurgery|date=Sep 2014|volume=75|issue=3|pages=306–14; discussion 314|pmid=24978859|doi=10.1227/NEU.0000000000000380}}</ref> | |||
==References== | ==References== | ||
Revision as of 19:44, 12 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
If left untreated, majority of patients with craniopharyngioma may progress to develop increased intracranial pressure, blindness and endocrine abnormalities. the prognosis of craniopharyngioma is good with treatment. The 5-year and 10-year survival rates are higher than 90%.
Natural History
- Craniopharyngiomas are slow growing tumors and symptoms often are present for a year or more before the diagnosis is established.
- Untreated patients can have increased intracranial pressure, visual disturbances and endocrine abnormalities.
Complications
A large percentage of patients have long-term hormone, vision, and nervous system problems after craniopharyngioma is treated. When the tumor is not completely removed, the condition may recur.[1]
There are complications caused by the radical surgical treatment of craniopharyngioma:[2]
- Obesity, which can be life-threatening. Hypothalamic-sparing surgical techniques may result in reduced postoperative obesity without an increase in tumor recurrence
- Hormone replacement therapy
- Severe behavioral problems
- Blindness
- Seizures
- Spinal fluid leak
- False aneurysms
- Difficulty with eye movements
- Death from intraoperative hemorrhage, hypothalamic damage, or stroke (rare)
Prognosis
- Craniopharyngioma is a benign tumor, the 5-year and 10-year survival rates, regardless of treatment given, are higher than 90%. [3]
- Patients can have a permanent cure if the tumor can be completely removed with surgery or treated with high doses of radiation.[4]
- The outlook depends on whether or not the tumor can be removed by surgery.
- The neurological deficits and hormonal imbalances caused by the tumor and the treatment The patient’s general health
- Recent research has demonstrated malignant tendency of craniopharyngiomas.
- These malignant craniopharyngiomas are very rare, but are associated with poor prognosis.[5]
References
- ↑ Complications of Craniopharyngioma. National library of medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm
- ↑ Complications. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc
- ↑ Prognosis of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc
- ↑ Prognosis. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm
- ↑ Sofela, AA; Hettige, S; Curran, O; Bassi, S (Sep 2014). "Malignant transformation in craniopharyngiomas". Neurosurgery. 75 (3): 306–14, discussion 314. doi:10.1227/NEU.0000000000000380. PMID 24978859.