Gonadoblastoma epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
The [[prevalence]] of gonadoblastoma | The [[prevalence]] of gonadoblastoma depends on the chromosomal content, presence or absence of [[mosaicism]], gonadal [[histology]], and age of the patient and varies between 15% to 30%. The [[incidence]] of gonadoblastoma varies according to the presence or absence of [[Y chromosome|Y chromosomal]] content and age of the individual. Patients with [[Turner syndrome]] who have [[Y chromosome|Y chromosomal]] content either completely or partially may develop gonadoblastoma with an incidence as high as 43%. Phenotypical females with XY [[gonadal]] abnormalities have been observed to develop gonadoblastoma by 40%. Gonadoblastoma may be found at any age, but commonly presents before the age of 15 years. Since, it usually affects individuals with [[gonadal dysgenesis]], there is no [[genotype]]-[[phenotype]] correlation. Phenotypically, it tends to affect female individuals to a greater extent. | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
===Incidence=== | ===Incidence=== | ||
*The [[incidence]] of gonadoblastoma | *The [[incidence]] of gonadoblastoma varies according to the presence or absence of [[Y chromosome|Y chromosom]]<nowiki/>[[Y chromosome|al]] content and age of the individual.<ref name="pmid16600779">{{cite journal |vauthors=Brant WO, Rajimwale A, Lovell MA, Travers SH, Furness PD, Sorensen M, Oottamasathien S, Koyle MA |title=Gonadoblastoma and Turner syndrome |journal=J. Urol. |volume=175 |issue=5 |pages=1858–60 |date=May 2006 |pmid=16600779 |doi=10.1016/S0022-5347(05)0032-8 |url=}}</ref><ref name="978-1-4557-4858-7">{{cite book | last = Sperling | first = M | title = Pediatric endocrinology | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2014 | isbn = 978-1-4557-4858-7 }}</ref> | ||
*Phenotypical female with XY gonadal abnormalities have been observed to develop gonadoblastoma by 40%. | *Phenotypical female with XY gonadal abnormalities have been observed to develop gonadoblastoma by 40%. | ||
*Patients with [[Turner syndrome]] who have [[Y chromosome|Y chromosom]]<nowiki/>al content either completely or partially can develop gonadoblastoma with an [[incidence]] as high as 43%. | *Patients with [[Turner syndrome]] who have [[Y chromosome|Y chromosom]]<nowiki/>[[Y chromosome|al]] content either completely or partially can develop gonadoblastoma with an [[incidence]] as high as 43%. | ||
===Prevalence=== | ===Prevalence=== | ||
*The [[prevalence]] of gonadoblastoma | *The [[prevalence]] of gonadoblastoma depends on the chromosomal content, presence or absence of [[mosaicism]], gonadal [[histology]] and age of the patient and varies between 15% to 30%.<ref name="urlYen & Jaffes Reproductive Endocrinology | ScienceDirect">{{cite web |url=https://www.sciencedirect.com/book/9781455727582/yen-and-jaffes-reproductive-endocrinology#book-info |title=Yen & Jaffe's Reproductive Endocrinology | ScienceDirect |format= |work= |accessdate=}}</ref> | ||
===Age=== | ===Age=== | ||
*Gonadoblastoma affects individuals of any age but | *Gonadoblastoma affects individuals of any age but commonly presents before 15 years of age.<ref name="pmid4193741">{{cite journal| author=Scully RE| title=Gonadoblastoma. A review of 74 cases. | journal=Cancer | year= 1970 | volume= 25 | issue= 6 | pages= 1340-56 | pmid=4193741 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4193741 }}</ref> | ||
===Race=== | ===Race=== | ||
| Line 28: | Line 29: | ||
===Gender=== | ===Gender=== | ||
*It commonly originated from dysgenetic [[gonad]] but has been observed in women with normal [[ovary]] and [[karyotype]]<nowiki/>s, although | *It commonly originated from dysgenetic [[gonad]] but has been observed in women with normal [[ovary]] and [[karyotype]]<nowiki/>s, although rare.<ref name="pmid4193741">{{cite journal| author=Scully RE| title=Gonadoblastoma. A review of 74 cases. | journal=Cancer | year= 1970 | volume= 25 | issue= 6 | pages= 1340-56 | pmid=4193741 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4193741 }}</ref><ref name="pmid10226831">{{cite journal |vauthors=Hatano T, Yoshino Y, Kawashima Y, Shirai H, Iizuka N, Miyazawa Y, Sakata A, Onishi T |title=Case of gonadoblastoma in a 9-year-old boy without physical abnormalities |journal=Int. J. Urol. |volume=6 |issue=3 |pages=164–6 |date=March 1999 |pmid=10226831 |doi= |url=}}</ref> | ||
* Since this tumor affects [[gonad]]<nowiki/>s, there is no [[genotype]]-[[phenotype]] correlations. | * Since this tumor affects [[gonad]]<nowiki/>s, there is no [[genotype]]-[[phenotype]] correlations. | ||
* The majority of affected individuals | * The majority of affected individuals appears to be phenotypically female, however, are [[intersex]]. | ||
*Although very uncommon, there are reports of gonadoblastoma development in phenotypically and genotypically normal men. | *Although very uncommon, there are reports of gonadoblastoma development in phenotypically and genotypically normal men. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
The prevalence of gonadoblastoma depends on the chromosomal content, presence or absence of mosaicism, gonadal histology, and age of the patient and varies between 15% to 30%. The incidence of gonadoblastoma varies according to the presence or absence of Y chromosomal content and age of the individual. Patients with Turner syndrome who have Y chromosomal content either completely or partially may develop gonadoblastoma with an incidence as high as 43%. Phenotypical females with XY gonadal abnormalities have been observed to develop gonadoblastoma by 40%. Gonadoblastoma may be found at any age, but commonly presents before the age of 15 years. Since, it usually affects individuals with gonadal dysgenesis, there is no genotype-phenotype correlation. Phenotypically, it tends to affect female individuals to a greater extent.
Epidemiology and Demographics
Incidence
- The incidence of gonadoblastoma varies according to the presence or absence of Y chromosomal content and age of the individual.[1][2]
- Phenotypical female with XY gonadal abnormalities have been observed to develop gonadoblastoma by 40%.
- Patients with Turner syndrome who have Y chromosomal content either completely or partially can develop gonadoblastoma with an incidence as high as 43%.
Prevalence
- The prevalence of gonadoblastoma depends on the chromosomal content, presence or absence of mosaicism, gonadal histology and age of the patient and varies between 15% to 30%.[3]
Age
- Gonadoblastoma affects individuals of any age but commonly presents before 15 years of age.[4]
Race
- There is no racial predilection to gonadoblastoma.
Gender
- It commonly originated from dysgenetic gonad but has been observed in women with normal ovary and karyotypes, although rare.[4][5]
- Since this tumor affects gonads, there is no genotype-phenotype correlations.
- The majority of affected individuals appears to be phenotypically female, however, are intersex.
- Although very uncommon, there are reports of gonadoblastoma development in phenotypically and genotypically normal men.
References
- ↑ Brant WO, Rajimwale A, Lovell MA, Travers SH, Furness PD, Sorensen M, Oottamasathien S, Koyle MA (May 2006). "Gonadoblastoma and Turner syndrome". J. Urol. 175 (5): 1858–60. doi:10.1016/S0022-5347(05)0032-8. PMID 16600779.
- ↑ Sperling, M (2014). Pediatric endocrinology. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1-4557-4858-7.
- ↑ "Yen & Jaffe's Reproductive Endocrinology | ScienceDirect".
- ↑ 4.0 4.1 Scully RE (1970). "Gonadoblastoma. A review of 74 cases". Cancer. 25 (6): 1340–56. PMID 4193741.
- ↑ Hatano T, Yoshino Y, Kawashima Y, Shirai H, Iizuka N, Miyazawa Y, Sakata A, Onishi T (March 1999). "Case of gonadoblastoma in a 9-year-old boy without physical abnormalities". Int. J. Urol. 6 (3): 164–6. PMID 10226831.