Gonadoblastoma epidemiology and demographics: Difference between revisions
No edit summary |
No edit summary |
||
| Line 39: | Line 39: | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category: | [[Category:Medicine]] | ||
[[Category:Primary care]] | |||
[[Category:Oncology]] | |||
[[Category:Gynecology]] | |||
[[Category:Up-To-Date]] | |||
Revision as of 17:54, 19 February 2019
|
Gonadoblastoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Gonadoblastoma epidemiology and demographics On the Web |
|
American Roentgen Ray Society Images of Gonadoblastoma epidemiology and demographics |
|
Risk calculators and risk factors for Gonadoblastoma epidemiology and demographics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
The prevalence of gonadoblastoma depends on the chromosomal content, presence or absence of mosaicism, gonadal histology, and age of the patient and varies between 15% to 30%. The incidence of gonadoblastoma varies according to the presence or absence of Y chromosomal content and age of the individual. Patients with Turner syndrome who have Y chromosomal content either completely or partially may develop gonadoblastoma with an incidence as high as 43%. Phenotypical females with XY gonadal abnormalities have been observed to develop gonadoblastoma by 40%. Gonadoblastoma may be found at any age, but commonly presents before the age of 15 years. Since, it usually affects individuals with gonadal dysgenesis, there is no genotype-phenotype correlation. Phenotypically, it tends to affect female individuals to a greater extent.
Epidemiology and Demographics
Incidence
- The incidence of gonadoblastoma varies according to the presence or absence of Y chromosomal content and age of the individual.[1][2]
- Phenotypical female with XY gonadal abnormalities have been observed to develop gonadoblastoma by 40%.
- Patients with Turner syndrome who have Y chromosomal content either completely or partially can develop gonadoblastoma with an incidence as high as 43%.
Prevalence
- The prevalence of gonadoblastoma depends on the chromosomal content, presence or absence of mosaicism, gonadal histology and age of the patient and varies between 15% to 30%.[3]
Age
- Gonadoblastoma affects individuals of any age but commonly presents before 15 years of age.[4]
Race
- There is no racial predilection to gonadoblastoma.
Gender
- It commonly originated from dysgenetic gonad but has been observed in women with normal ovary and karyotypes, although rare.[4][5]
- Since this tumor affects gonads, there is no genotype-phenotype correlations.
- The majority of affected individuals appears to be phenotypically female, however, are intersex.
- Although very uncommon, there are reports of gonadoblastoma development in phenotypically and genotypically normal men.
References
- ↑ Brant WO, Rajimwale A, Lovell MA, Travers SH, Furness PD, Sorensen M, Oottamasathien S, Koyle MA (May 2006). "Gonadoblastoma and Turner syndrome". J. Urol. 175 (5): 1858–60. doi:10.1016/S0022-5347(05)0032-8. PMID 16600779.
- ↑ Sperling, M (2014). Pediatric endocrinology. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1-4557-4858-7.
- ↑ "Yen & Jaffe's Reproductive Endocrinology | ScienceDirect".
- ↑ 4.0 4.1 Scully RE (1970). "Gonadoblastoma. A review of 74 cases". Cancer. 25 (6): 1340–56. PMID 4193741.
- ↑ Hatano T, Yoshino Y, Kawashima Y, Shirai H, Iizuka N, Miyazawa Y, Sakata A, Onishi T (March 1999). "Case of gonadoblastoma in a 9-year-old boy without physical abnormalities". Int. J. Urol. 6 (3): 164–6. PMID 10226831.