Gestational trophoblastic neoplasia causes: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 6: | Line 6: | ||
==Causes== | ==Causes== | ||
The causality of gestational trophoblastic neoplasia based on the subtypes is as follows: | |||
'''Hydatidiform mole''' | |||
*Complete mole arises when an ovum without maternal chromosomes is fertilized by one sperm which duplicates its DNA, resulting in a 46XX androgenetic karyotype.<ref name="YamashitaIshikawa1981">{{cite journal|last1=Yamashita|first1=Kohki|last2=Ishikawa|first2=Mutsuo|last3=Shimizu|first3=Tetsuya|last4=Kuroda|first4=Makoto|title=HLA antigens in husband-wife pairs with trophoblastic tumor|journal=Gynecologic Oncology|volume=12|issue=1|year=1981|pages=68–74|issn=00908258|doi=10.1016/0090-8258(81)90096-2}}</ref><ref name="pmid9475155">{{cite journal |vauthors=Fisher RA, Newlands ES |title=Gestational trophoblastic disease. Molecular and genetic studies |journal=J Reprod Med |volume=43 |issue=1 |pages=87–97 |date=January 1998 |pmid=9475155 |doi= |url=}}</ref> | |||
*Partial moles are almost always triploid, resulting from the fertilization of a healthy ovum by two sperms.<ref name="SzulmanSurti1978">{{cite journal|last1=Szulman|first1=A.E.|last2=Surti|first2=Urvashi|title=The syndromes of hydatidiform mole|journal=American Journal of Obstetrics and Gynecology|volume=131|issue=6|year=1978|pages=665–671|issn=00029378|doi=10.1016/0002-9378(78)90829-3}}</ref><ref name="LawlerFisher1991">{{cite journal|last1=Lawler|first1=Sylvia D.|last2=Fisher|first2=Rosemary A.|last3=Dent|first3=Joan|title=A prospective genetic study of complete and partial hydatidiform moles|journal=American Journal of Obstetrics and Gynecology|volume=164|issue=5|year=1991|pages=1270–1277|issn=00029378|doi=10.1016/0002-9378(91)90698-Q}}</ref><ref name="pmid1371185">{{cite journal |vauthors=Lage JM, Mark SD, Roberts DJ, Goldstein DP, Bernstein MR, Berkowitz RS |title=A flow cytometric study of 137 fresh hydropic placentas: correlation between types of hydatidiform moles and nuclear DNA ploidy |journal=Obstet Gynecol |volume=79 |issue=3 |pages=403–10 |date=March 1992 |pmid=1371185 |doi= |url=}}</ref> | |||
==References== | ==References== | ||
Revision as of 22:27, 19 February 2019
|
Gestational trophoblastic neoplasia Microchapters |
|
Differentiating Gestational trophoblastic neoplasia from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Gestational trophoblastic neoplasia causes On the Web |
|
American Roentgen Ray Society Images of Gestational trophoblastic neoplasia causes |
|
Directions to Hospitals Treating Gestational trophoblastic neoplasia |
|
Risk calculators and risk factors for Gestational trophoblastic neoplasia causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]
Overview
Causes
The causality of gestational trophoblastic neoplasia based on the subtypes is as follows:
Hydatidiform mole
- Complete mole arises when an ovum without maternal chromosomes is fertilized by one sperm which duplicates its DNA, resulting in a 46XX androgenetic karyotype.[1][2]
- Partial moles are almost always triploid, resulting from the fertilization of a healthy ovum by two sperms.[3][4][5]
References
- ↑ Yamashita, Kohki; Ishikawa, Mutsuo; Shimizu, Tetsuya; Kuroda, Makoto (1981). "HLA antigens in husband-wife pairs with trophoblastic tumor". Gynecologic Oncology. 12 (1): 68–74. doi:10.1016/0090-8258(81)90096-2. ISSN 0090-8258.
- ↑ Fisher RA, Newlands ES (January 1998). "Gestational trophoblastic disease. Molecular and genetic studies". J Reprod Med. 43 (1): 87–97. PMID 9475155.
- ↑ Szulman, A.E.; Surti, Urvashi (1978). "The syndromes of hydatidiform mole". American Journal of Obstetrics and Gynecology. 131 (6): 665–671. doi:10.1016/0002-9378(78)90829-3. ISSN 0002-9378.
- ↑ Lawler, Sylvia D.; Fisher, Rosemary A.; Dent, Joan (1991). "A prospective genetic study of complete and partial hydatidiform moles". American Journal of Obstetrics and Gynecology. 164 (5): 1270–1277. doi:10.1016/0002-9378(91)90698-Q. ISSN 0002-9378.
- ↑ Lage JM, Mark SD, Roberts DJ, Goldstein DP, Bernstein MR, Berkowitz RS (March 1992). "A flow cytometric study of 137 fresh hydropic placentas: correlation between types of hydatidiform moles and nuclear DNA ploidy". Obstet Gynecol. 79 (3): 403–10. PMID 1371185.