Cowden syndrome epidemiology and demographics: Difference between revisions

Revision as of 16:55, 22 February 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

The incidence of cowden syndrome is approximately 1 per 200,000 to 250,000 individuals worldwide.^[1]^[2]

The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
The prevalence of [disease/malignancy] is estimated to be [number] cases annually.

In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
The case-fatality rate/mortality rate of [disease name] is approximately [number range].

Patients of all age groups may develop [disease name].
The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.
[Disease name] commonly affects individuals younger than/older than [number of years] years of age.
[Chronic disease name] is usually first diagnosed among [age group].
[Acute disease name] commonly affects [age group].

There is no racial predilection to [disease name].
[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].

[Disease name] affects men and women equally.
[Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number > 1] to 1.

[Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].

↑ Nelen MR, Kremer H, Konings IB, Schoute F, van Essen AJ, Koch R, Woods CG, Fryns JP, Hamel B, Hoefsloot LH, Peeters EA, Padberg GW (April 1999). "Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations". Eur. J. Hum. Genet. 7 (3): 267–73. doi:10.1038/sj.ejhg.5200289. PMID 10234502.
↑ Eng, C. (2000). "Will the real Cowden syndrome please stand up: revised diagnostic criteria". Journal of Medical Genetics. 37 (11): 828–830. doi:10.1136/jmg.37.11.828. ISSN 1468-6244.

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 ==Epidemiology and Demographics==
 ===Incidence===
-*The [[incidence]] of [[cowden syndrome]] is approximately 1 per 200,000 to 250,000 individuals worldwide.<ref name="pmid10234502">{{cite journal |vauthors=Nelen MR, Kremer H, Konings IB, Schoute F, van Essen AJ, Koch R, Woods CG, Fryns JP, Hamel B, Hoefsloot LH, Peeters EA, Padberg GW |title=Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations |journal=Eur. J. Hum. Genet. |volume=7 |issue=3 |pages=267–73 |date=April 1999 |pmid=10234502 |doi=10.1038/sj.ejhg.5200289 |url=}}</ref>
+*The [[incidence]] of [[cowden syndrome]] is approximately 1 per 200,000 to 250,000 individuals worldwide.<ref name="pmid10234502">{{cite journal |vauthors=Nelen MR, Kremer H, Konings IB, Schoute F, van Essen AJ, Koch R, Woods CG, Fryns JP, Hamel B, Hoefsloot LH, Peeters EA, Padberg GW |title=Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations |journal=Eur. J. Hum. Genet. |volume=7 |issue=3 |pages=267–73 |date=April 1999 |pmid=10234502 |doi=10.1038/sj.ejhg.5200289 |url=}}</ref><ref name="Eng2000">{{cite journal|last1=Eng|first1=C.|title=Will the real Cowden syndrome please stand up: revised diagnostic criteria|journal=Journal of Medical Genetics|volume=37|issue=11|year=2000|pages=828–830|issn=14686244|doi=10.1136/jmg.37.11.828}}</ref>
 ===Prevalence===