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| [[File:Pathogenesis of high grade serous carcinoma.jpg|alt=Pathogenesis of high grade serous carcinoma|center|frame|Pathogenesis of high grade serous carcinoma<ref name="pmid27898521">{{cite journal |vauthors=Kroeger PT, Drapkin R |title=Pathogenesis and heterogeneity of ovarian cancer |journal=Curr. Opin. Obstet. Gynecol. |volume=29 |issue=1 |pages=26–34 |date=February 2017 |pmid=27898521 |pmc=5201412 |doi=10.1097/GCO.0000000000000340 |url=}}</ref>
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| Normal fallopian tube epithelium comprises of both secretory and ciliated cells and stains negative for p53. The benign ‘p53 signature’: secretory cells that possess strong p53 expression and evidence of DNA damage but are not proliferative. When they progress to serous tubal intraepithelial carcinoma or ‘STIC’, they acquire nuclear pleomorphism, mitoses, and loss of polarity. Serous tubal intraepithelial carcinoma shares all these properties with invasive high grade serous epithelial ovarian cancer and clinical symptoms typically emerge with advanced disease.<ref name="pmid27898521">{{cite journal |vauthors=Kroeger PT, Drapkin R |title=Pathogenesis and heterogeneity of ovarian cancer |journal=Curr. Opin. Obstet. Gynecol. |volume=29 |issue=1 |pages=26–34 |date=February 2017 |pmid=27898521 |pmc=5201412 |doi=10.1097/GCO.0000000000000340 |url=}}</ref><ref name="pmid19746182">{{cite journal |vauthors=Karst AM, Drapkin R |title=Ovarian cancer pathogenesis: a model in evolution |journal=J Oncol |volume=2010 |issue= |pages=932371 |date=2010 |pmid=19746182 |pmc=2739011 |doi=10.1155/2010/932371 |url=}}</ref>]]
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| [[File:DNA damage and repair mechanisms..jpg|alt=DNA damage and repair mechanisms.|center|frame|DNA damage and repair mechanisms.<ref name="pmid26075229">{{cite journal |vauthors=Toss A, Tomasello C, Razzaboni E, Contu G, Grandi G, Cagnacci A, Schilder RJ, Cortesi L |title=Hereditary ovarian cancer: not only BRCA 1 and 2 genes |journal=Biomed Res Int |volume=2015 |issue= |pages=341723 |date=2015 |pmid=26075229 |pmc=4449870 |doi=10.1155/2015/341723 |url=}}</ref>]]
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| ==References== | | ==References== |
| {{reflist|2}} | | {{reflist|2}} |
Revision as of 14:43, 26 February 2019