Epithelial ovarian cancer: Difference between revisions
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|- | |- | ||
|Src | |Src | ||
|Involved in regulation of | |||
* Gene transcription | |||
* Angiogenesis | |||
* Cellular adhesion | |||
* Cellular proliferation | |||
| | | | ||
* Activating mutation | |||
* Increased angiogenesis | |||
* Decreased cellular adhesion | |||
* Increased tumor metastasis | |||
* Increased cellular proliferation | |||
|- | |- | ||
|CSF-1/fms | |CSF-1/fms | ||
Revision as of 15:26, 26 February 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Hannan Javed, M.D.[2]
| Possible genetic alteration in epithelial ovarian cancers | ||
|---|---|---|
| Protein | Normal function | Result of mutation |
| Epidermal growth factor receptor (HER-1)[1][2] |
|
|
| Human Epidermal Growth Factor Receptor 2 (HER-2)[1][2] |
|
|
| Src | Involved in regulation of
|
|
| CSF-1/fms | ||
| ILGF/ILGFR | ||
| k-ras | ||
| b-raf | ||
| TGF-β | ||
| myc | ||
| Cyclin D/Cdk4/6 | ||
| Cyclin E/Cdk2 | ||
| Cyclin B/Cdk1 | ||
| p16 | ||
| p27 (kip-1) | ||
| p21 (WAF-1) | ||
| NFκB | ||
| NOEY(ARHI) | ||
| PIP3/Akt | ||
| PTEN | ||
| p53 | ||
| BRCA1 | ||
| BRCA2 | ||
| MLH1/MSH2 | ||
| Fas ligand | ||
| HLA-G | ||
| hTERT | ||
| VEGF/VEGFR | ||
| IL-8 | ||
| EphA2 | ||
| MMPs | ||
| αvβ3 | ||
| FAK | ||
| E-cadherin | ||
References
- ↑ 1.0 1.1 Wee P, Wang Z (May 2017). "Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways". Cancers (Basel). 9 (5). doi:10.3390/cancers9050052. PMC 5447962. PMID 28513565.
- ↑ 2.0 2.1 Iqbal N, Iqbal N (2014). "Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications". Mol Biol Int. 2014: 852748. doi:10.1155/2014/852748. PMC 4170925. PMID 25276427.