Ovarian germ cell tumor natural history: Difference between revisions
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***Larger tumors | ***Larger tumors | ||
*Rupture in < 4% of the affected individuals.<ref name="AyhanBukulmez2000">{{cite journal|last1=Ayhan|first1=Ali|last2=Bukulmez|first2=Orhan|last3=Genc|first3=Cuneyt|last4=Karamursel|first4=Burcu S.|last5=Ayhan|first5=Ayse|title=Mature cystic teratomas of the ovary: case series from one institution over 34 years|journal=European Journal of Obstetrics & Gynecology and Reproductive Biology|volume=88|issue=2|year=2000|pages=153–157|issn=03012115|doi=10.1016/S0301-2115(99)00141-4}}</ref> | *Rupture in < 4% of the affected individuals.<ref name="AyhanBukulmez2000">{{cite journal|last1=Ayhan|first1=Ali|last2=Bukulmez|first2=Orhan|last3=Genc|first3=Cuneyt|last4=Karamursel|first4=Burcu S.|last5=Ayhan|first5=Ayse|title=Mature cystic teratomas of the ovary: case series from one institution over 34 years|journal=European Journal of Obstetrics & Gynecology and Reproductive Biology|volume=88|issue=2|year=2000|pages=153–157|issn=03012115|doi=10.1016/S0301-2115(99)00141-4}}</ref> | ||
**Rupture may be associated with leakage of sebaceous contents of the tumor into the peritoneal cavity and leads to granulomatous peritonitis.<ref name="pmid8008317">{{cite journal |vauthors=Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL |title=Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature |journal=Obstet Gynecol |volume=84 |issue=1 |pages=22–8 |date=July 1994 |pmid=8008317 |doi= |url=}}</ref> | |||
***This complication is very rere and happens in less than 1% of the affected individuals. | |||
*This tumor may be bilateral in 8% to 15% of cases. | *This tumor may be bilateral in 8% to 15% of cases. | ||
*Malignant transformation of the tumor may also happen in approximately 2% of affected individuals.<ref name="pmid2841767">{{cite journal |vauthors=Singh P, Yordan EL, Wilbanks GD, Miller AW, Wee A |title=Malignancy associated with benign cystic teratomas (dermoid cysts) of the ovary |journal=Singapore Med J |volume=29 |issue=1 |pages=30–4 |date=February 1988 |pmid=2841767 |doi= |url=}}</ref> | *Malignant transformation of the tumor may also happen in approximately 2% of affected individuals.<ref name="pmid2841767">{{cite journal |vauthors=Singh P, Yordan EL, Wilbanks GD, Miller AW, Wee A |title=Malignancy associated with benign cystic teratomas (dermoid cysts) of the ovary |journal=Singapore Med J |volume=29 |issue=1 |pages=30–4 |date=February 1988 |pmid=2841767 |doi= |url=}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
The prognosis of germ cells of the ovary depends on the type of the tumor and its malignant potentials. Possible complications of benign teratomas are a rupture and ovarian torsion also malignant transformation. If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of ovarian germ cell tumors usually develop in the teenage years with abdominal pain or fullness, and palpable pelvic/abdominal mass.[1]
- The symptoms of (disease name) typically develop ___ years after exposure to ___.
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
Mature teratoma
Common complications of mature teratoma include:[2]
- Ovarian torsion is the most common complication and affects 5% to 10% of the individuals.
- It happens at a greater extent in:[3]
- Younger age (10-19 years)
- Larger tumors
- It happens at a greater extent in:[3]
- Rupture in < 4% of the affected individuals.[2]
- Rupture may be associated with leakage of sebaceous contents of the tumor into the peritoneal cavity and leads to granulomatous peritonitis.[4]
- This complication is very rere and happens in less than 1% of the affected individuals.
- Rupture may be associated with leakage of sebaceous contents of the tumor into the peritoneal cavity and leads to granulomatous peritonitis.[4]
- This tumor may be bilateral in 8% to 15% of cases.
- Malignant transformation of the tumor may also happen in approximately 2% of affected individuals.[5]
- The tumor undergoes malignant transformation to squamous cell carcinma in 80% of them and to adenocarcinoma in the rest of the cases.
Prognosis
Mature teratoma
- Prognosis is generally excellent in the mature teratoma, but in case of simultaneous malignant transformation, the 5-year survival rate of patients is approximately [15-30]%.[6]
- Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ Low, Jeffrey J.H.; Ilancheran, Arunachalam; Ng, Joseph S. (2012). "Malignant ovarian germ-cell tumours". Best Practice & Research Clinical Obstetrics & Gynaecology. 26 (3): 347–355. doi:10.1016/j.bpobgyn.2012.01.002. ISSN 1521-6934.
- ↑ 2.0 2.1 Ayhan, Ali; Bukulmez, Orhan; Genc, Cuneyt; Karamursel, Burcu S.; Ayhan, Ayse (2000). "Mature cystic teratomas of the ovary: case series from one institution over 34 years". European Journal of Obstetrics & Gynecology and Reproductive Biology. 88 (2): 153–157. doi:10.1016/S0301-2115(99)00141-4. ISSN 0301-2115.
- ↑ Kim, Min Jae; Kim, Na Young; Lee, Dong-Yun; Yoon, Byung-Koo; Choi, DooSeok (2011). "Clinical characteristics of ovarian teratoma: age-focused retrospective analysis of 580 cases". American Journal of Obstetrics and Gynecology. 205 (1): 32.e1–32.e4. doi:10.1016/j.ajog.2011.02.044. ISSN 0002-9378.
- ↑ Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL (July 1994). "Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature". Obstet Gynecol. 84 (1): 22–8. PMID 8008317.
- ↑ Singh P, Yordan EL, Wilbanks GD, Miller AW, Wee A (February 1988). "Malignancy associated with benign cystic teratomas (dermoid cysts) of the ovary". Singapore Med J. 29 (1): 30–4. PMID 2841767.
- ↑ Park, Jeong-Yeol; Kim, Dae-Yeon; Kim, Jong-Hyeok; Kim, Yong-Man; Kim, Young-Tak; Nam, Joo-Hyun (2008). "Malignant transformation of mature cystic teratoma of the ovary: Experience at a single institution". European Journal of Obstetrics & Gynecology and Reproductive Biology. 141 (2): 173–178. doi:10.1016/j.ejogrb.2008.07.032. ISSN 0301-2115.