Desmoid tumor diagnostic study of choice: Difference between revisions
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{{CMG}} {{AE}}{{S.M.}} | {{CMG}} {{AE}}{{S.M.}} | ||
==Overview== | ==Overview== | ||
Diagnostic study of choice for desmoid tumors is biopsy. After biopsy, | Diagnostic study of choice for desmoid tumors is biopsy. After biopsy, definitive diagnosis must be established on histopathologic analysis. Electron microscopy is done which shows spindle cells of desmoids appearing as myofibroblasts. Immunohistochemical stains show high nuclear reactivity for beta-catenin accumulation in nucleus. | ||
==Diagnostic study of choice== | ==Diagnostic study of choice== | ||
*Biopsy is the most important and conclusive diagnostic procedure for desmoid tumor | *Biopsy is the most important and conclusive diagnostic procedure for desmoid tumor | ||
*After biopsy, | *After biopsy, definitive diagnosis must be established on histopathologic analysis | ||
*Electron microscopy is performed to obtain further clarity and confirmation for the diagnosis | |||
*Spindle cells of desmoid tumors appear to be myofibroblasts on electron microscopy which represents an abnormal proliferation of myofibroblasts, which normally disappear gradually during the later stages of wound healing | *Spindle cells of desmoid tumors appear to be myofibroblasts on electron microscopy which represents an abnormal proliferation of myofibroblasts, which normally disappear gradually during the later stages of wound healing | ||
*Immunohistochemical stains are done to look for nuclear accumulation of beta-catenin | *Immunohistochemical stains are done to look for nuclear accumulation of beta-catenin | ||
*Regardless of the site, 90% of desmoids show nuclear reactivity (has relatively high specificity) | *Regardless of the site, 90% of desmoids show nuclear reactivity (has relatively high specificity) | ||
Revision as of 21:03, 28 February 2019
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Desmoid tumor Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
Diagnostic study of choice for desmoid tumors is biopsy. After biopsy, definitive diagnosis must be established on histopathologic analysis. Electron microscopy is done which shows spindle cells of desmoids appearing as myofibroblasts. Immunohistochemical stains show high nuclear reactivity for beta-catenin accumulation in nucleus.
Diagnostic study of choice
- Biopsy is the most important and conclusive diagnostic procedure for desmoid tumor
- After biopsy, definitive diagnosis must be established on histopathologic analysis
- Electron microscopy is performed to obtain further clarity and confirmation for the diagnosis
- Spindle cells of desmoid tumors appear to be myofibroblasts on electron microscopy which represents an abnormal proliferation of myofibroblasts, which normally disappear gradually during the later stages of wound healing
- Immunohistochemical stains are done to look for nuclear accumulation of beta-catenin
- Regardless of the site, 90% of desmoids show nuclear reactivity (has relatively high specificity)