Ovarian germ cell tumor laboratory tests: Difference between revisions
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The laboratory findings associated with ovarian germ cell tumor are serum [[lactate dehydrogenase]] (LDH), [[human chorionic gonadotropin]] (HCG), [[CA-125]], and [[alpha-fetoprotein]] (AFP).<ref name = anc> Ovary: Germ cell tumors. http://atlasgeneticsoncology.org/Tumors/OvarianGermCellID5067.html. URL Accessed on November 10, 2015</ref> | The laboratory findings associated with ovarian germ cell tumor are serum [[lactate dehydrogenase]] (LDH), [[human chorionic gonadotropin]] (HCG), [[CA-125]], and [[alpha-fetoprotein]] (AFP).<ref name = anc> Ovary: Germ cell tumors. http://atlasgeneticsoncology.org/Tumors/OvarianGermCellID5067.html. URL Accessed on November 10, 2015</ref> | ||
==Ovarian germ cell tumor Laboratory Findings== | ==Ovarian germ cell tumor Laboratory Findings== | ||
An elevated concentration a-fetoprotein (AFP) and b-human chorionic gonadotrophin (b-HCG) are diagnostic of malignant ovarian germ cell tumors.<ref name="PectasidesPectasides2008">{{cite journal|last1=Pectasides|first1=D.|last2=Pectasides|first2=E.|last3=Kassanos|first3=D.|title=Germ cell tumors of the ovary|journal=Cancer Treatment Reviews|volume=34|issue=5|year=2008|pages=427–441|issn=03057372|doi=10.1016/j.ctrv.2008.02.002}}</ref> | |||
The tumor marker associated with ovarian germ cell tumor subtypes are as follows:<ref name= anc> Ovary: Germ cell tumors. http://atlasgeneticsoncology.org/Tumors/OvarianGermCellID5067.html. URL Accessed on November 10, 2015</ref> | The tumor marker associated with ovarian germ cell tumor subtypes are as follows:<ref name= anc> Ovary: Germ cell tumors. http://atlasgeneticsoncology.org/Tumors/OvarianGermCellID5067.html. URL Accessed on November 10, 2015</ref> | ||
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===Mature teratoma=== | |||
* Mature teratoma is associated with increased level of CA 19-9. <ref name="Yayla AbideBostancı Ergen2018">{{cite journal|last1=Yayla Abide|first1=Çiğdem|last2=Bostancı Ergen|first2=Evrim|title=Retrospective analysis of mature cystic teratomas in a single center and review of the literature|journal=Journal of Turkish Society of Obstetric and Gynecology|volume=15|issue=2|year=2018|pages=95–98|issn=1307699X|doi=10.4274/tjod.86244}}</ref> | * Mature teratoma is associated with increased level of CA 19-9. <ref name="Yayla AbideBostancı Ergen2018">{{cite journal|last1=Yayla Abide|first1=Çiğdem|last2=Bostancı Ergen|first2=Evrim|title=Retrospective analysis of mature cystic teratomas in a single center and review of the literature|journal=Journal of Turkish Society of Obstetric and Gynecology|volume=15|issue=2|year=2018|pages=95–98|issn=1307699X|doi=10.4274/tjod.86244}}</ref> | ||
* There is a report suggesting a role for increased levels of CA 125, CA 153, and AFP tumor markers in differentiating the immature teratoma and mature teratoma.<ref name="pmid18184473">{{cite journal |vauthors=Chen C, Li JD, Huang H, Feng YL, Wang LH, Chen L |title=[Diagnostic value of multiple tumor marker detection for mature and immature teratoma of the ovary] |language=Chinese |journal=Ai Zheng |volume=27 |issue=1 |pages=92–5 |date=January 2008 |pmid=18184473 |doi= |url=}}</ref> | * There is a report suggesting a role for increased levels of CA 125, CA 153, and AFP tumor markers in differentiating the immature teratoma and mature teratoma.<ref name="pmid18184473">{{cite journal |vauthors=Chen C, Li JD, Huang H, Feng YL, Wang LH, Chen L |title=[Diagnostic value of multiple tumor marker detection for mature and immature teratoma of the ovary] |language=Chinese |journal=Ai Zheng |volume=27 |issue=1 |pages=92–5 |date=January 2008 |pmid=18184473 |doi= |url=}}</ref> | ||
There are no diagnostic laboratory findings associated with [disease name]. | There are no diagnostic laboratory findings associated with [disease name]. | ||
===Dysgerminoma=== | |||
*Pure dysgerminomaa, usually secret no hormones. However, 5% of tumors are capable of producing B-hCG.<ref name="ShaabanRezvani2014">{{cite journal|last1=Shaaban|first1=Akram M.|last2=Rezvani|first2=Maryam|last3=Elsayes|first3=Khaled M.|last4=Baskin|first4=Henry|last5=Mourad|first5=Amr|last6=Foster|first6=Bryan R.|last7=Jarboe|first7=Elke A.|last8=Menias|first8=Christine O.|title=Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features|journal=RadioGraphics|volume=34|issue=3|year=2014|pages=777–801|issn=0271-5333|doi=10.1148/rg.343130067}}</ref> | *Pure dysgerminomaa, usually secret no hormones. However, 5% of tumors are capable of producing B-hCG.<ref name="ShaabanRezvani2014">{{cite journal|last1=Shaaban|first1=Akram M.|last2=Rezvani|first2=Maryam|last3=Elsayes|first3=Khaled M.|last4=Baskin|first4=Henry|last5=Mourad|first5=Amr|last6=Foster|first6=Bryan R.|last7=Jarboe|first7=Elke A.|last8=Menias|first8=Christine O.|title=Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features|journal=RadioGraphics|volume=34|issue=3|year=2014|pages=777–801|issn=0271-5333|doi=10.1148/rg.343130067}}</ref> | ||
*Multinucleated syncytiotrophoblastic giant cells, in the dysgerminoma, produce B-hCG. | |||
*LDH and ALK-P may be elevated nonspecifically. | *LDH and ALK-P may be elevated nonspecifically. | ||
OR | OR | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal for patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
The laboratory findings associated with ovarian germ cell tumor are serum lactate dehydrogenase (LDH), human chorionic gonadotropin (HCG), CA-125, and alpha-fetoprotein (AFP).[1]
Ovarian germ cell tumor Laboratory Findings
An elevated concentration a-fetoprotein (AFP) and b-human chorionic gonadotrophin (b-HCG) are diagnostic of malignant ovarian germ cell tumors.[2] The tumor marker associated with ovarian germ cell tumor subtypes are as follows:[1]
| Ovarian germ cell tumor subtype | Tumor markers expressed |
| Dysgerminoma |
|
| Endodermal sinus tumor or yolk sac tumors |
|
| Embryonal Carcinoma |
|
| Teratoma |
|
| Choriocarcinoma |
|
Mature teratoma
- Mature teratoma is associated with increased level of CA 19-9. [3]
- There is a report suggesting a role for increased levels of CA 125, CA 153, and AFP tumor markers in differentiating the immature teratoma and mature teratoma.[4]
There are no diagnostic laboratory findings associated with [disease name].
Dysgerminoma
- Pure dysgerminomaa, usually secret no hormones. However, 5% of tumors are capable of producing B-hCG.[5]
- Multinucleated syncytiotrophoblastic giant cells, in the dysgerminoma, produce B-hCG.
- LDH and ALK-P may be elevated nonspecifically.
OR
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
[Test] is usually normal among patients with [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include:
- [Abnormal test 1]
- [Abnormal test 2]
- [Abnormal test 3]
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
References
- ↑ 1.0 1.1 Ovary: Germ cell tumors. http://atlasgeneticsoncology.org/Tumors/OvarianGermCellID5067.html. URL Accessed on November 10, 2015
- ↑ Pectasides, D.; Pectasides, E.; Kassanos, D. (2008). "Germ cell tumors of the ovary". Cancer Treatment Reviews. 34 (5): 427–441. doi:10.1016/j.ctrv.2008.02.002. ISSN 0305-7372.
- ↑ Yayla Abide, Çiğdem; Bostancı Ergen, Evrim (2018). "Retrospective analysis of mature cystic teratomas in a single center and review of the literature". Journal of Turkish Society of Obstetric and Gynecology. 15 (2): 95–98. doi:10.4274/tjod.86244. ISSN 1307-699X.
- ↑ Chen C, Li JD, Huang H, Feng YL, Wang LH, Chen L (January 2008). "[Diagnostic value of multiple tumor marker detection for mature and immature teratoma of the ovary]". Ai Zheng (in Chinese). 27 (1): 92–5. PMID 18184473.
- ↑ Shaaban, Akram M.; Rezvani, Maryam; Elsayes, Khaled M.; Baskin, Henry; Mourad, Amr; Foster, Bryan R.; Jarboe, Elke A.; Menias, Christine O. (2014). "Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features". RadioGraphics. 34 (3): 777–801. doi:10.1148/rg.343130067. ISSN 0271-5333.