Adenocarcinoma

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Evidence Based Medicine
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Definitions
Definitions of Adenocarcinoma
Patient Resources / Community
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List of terms related to Adenocarcinoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Adenocarcinoma is a form of carcinoma that originates in glandular tissue. To be classified as adenocarcinoma, the cells do not necessarily need to be part of a gland, as long as they have secretory properties. This form of carcinoma can occur in some higher mammals, including humans. The term adenocarcinoma is derived from 'adeno' meaning 'pertaining to a gland' and 'carcinoma', which describes a cancer that has developed in the epithelial cells. It can first present as an adenoma (a glandular tumor that is benign).

Pathophysiology

Examples of tissues where adenocarcinomas may arise:

• Breast cancer
• Colon cancer
• Lung cancer
• Prostate cancer
• Stomach cancer
• Pancreatic cancer (99% of pancreatic cancers are ductal adenocarcinomas [2])
• Cervical cancer
• Vaginal cancer

Gross Pathology

• 
  This cancer presented in a 40-year-old woman complaining of abdominal pain. Endoscopically it was a "very suspicious" ulcer. Biopsy showed diffusely infiltrating signet ring cell adenocarcinoma. These are gross photos of the subtotal gastrectomy specimen. The photo above is a seen face view of the ulcer. The pyloric margin is to the left. The ulcer is on the lesser curvature.
• 
  This is a longitudinal section cut in the plane of the lesser curvature. The pylorus is to the left. Note several prominent nodes of the lesser omentum; these contained metastatic cancer.

Physical Examination

Adenocarcinoma-In The Submandibular Salivary Glands

• 
  Adenocarcinoma-In The Submandibular Salivary Glands
  Adapted from Dermatology Atlas
• 
  Adenocarcinoma-In The Submandibular Salivary Glands
  Adapted from Dermatology Atlas
• 
  Adenocarcinoma-In The Submandibular Salivary Glands
  Adapted from Dermatology Atlas

Differential Diagnosis

Diseases	Risk factors/Epidemiology	History	Clinical Findings	Gross Pathology	Histopathology	Immunohistochemistry	Lab Findings	Imaging	Metastatic Potential	Gold Standard	Additional Findings
Head & Neck Cancer
Paranasal Sinus Cancer
Lung Cancer
Breast Cancer
Esophageal Cancer
Diseases	Risk factors/Epidemiology	History	Clinical Findings	Gross Pathology	Histopathology	Immunohistochemistry	Lab Findings	Imaging	Metastatic Potential	Gold Standard	Additional Findings
Gastric Cancer
Pancreatic Cancer
Small Bowel Cancer
Colorectal Cancer
Appendix Cancer
Diseases	Risk factors/Epidemiology	History	Clinical Findings	Gross Pathology	Histopathology	Immunohistochemistry	Lab Findings	Imaging	Metastatic Potential	Gold Standard	Additional Findings
Gallbladder Cancer
Anal Cancer
Cervical Cancer
Vaginal Cancer
Endometrial Cancer
Diseases	Risk factors/Epidemiology	History	Clinical Findings	Gross Pathology	Histopathology	Immunohistochemistry	Lab Findings	Imaging	Metastatic Potential	Gold Standard	Additional Findings
Vulvar Cancer
Prostate Cancer
Testicular Cancer
Urinary Bladder Cancer
Urethral Cancer
Metastatic Cancer

References

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