Thrombotic thrombocytopenic purpura classification: Difference between revisions
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==Overview== | ==Overview== | ||
TTP may be classified according to ''[[ADAMTS13]]'' [[gene]] [[Mutation|mutations]] and [[autoantibody]] against [[ADAMTS13]] into two subtypes: herditary [[Syndrome|syndromes]], aquired [[Syndrome|syndromes]] | TTP may be classified according to ''[[ADAMTS13]]'' [[gene]] [[Mutation|mutations]] and [[autoantibody]] against [[ADAMTS13]] into two subtypes: herditary [[Syndrome|syndromes]], aquired [[Syndrome|syndromes]]. | ||
==Classification== | ==Classification== | ||
Latest revision as of 12:02, 14 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
TTP may be classified according to ADAMTS13 gene mutations and autoantibody against ADAMTS13 into two subtypes: herditary syndromes, aquired syndromes.
Classification
TTP may be classified into several subtypes based on ADAMTS13 gene mutations(herditary syndromes) and autoantibody against ADAMTS13(aquired syndromes):[1][2]
1.Hereditary:
- Congenital TTP
- Inherited TTP
- Familial TTP
- Upshaw-Schulman syndrome (USS) is an autosomal recessive disease of ADAMTS13 gene on chromosome 9q34 .
2.Acquired
- Existence of an inhibitory antibody against ADAMTS13 due to the variety of conditions.
References
- ↑ Tersteeg C, Verhenne S, Roose E, Schelpe AS, Deckmyn H, De Meyer SF, Vanhoorelbeke K (2016). "ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies". Expert Rev Hematol. 9 (2): 209–21. doi:10.1586/17474086.2016.1122515. PMID 26581428.
- ↑ Yoshihiro Fujimura, Masanori Matsumoto, Hideo Yagi, Akira Yoshioka, Taei Matsui & Koiti Titani (2002). "Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome". International journal of hematology. 75 (1): 25–34. PMID 11843286. Unknown parameter
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