Pancreatic cancer causes: Difference between revisions
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==Overview== | ==Overview== | ||
[[Pancreatic cancer]] may be caused by the inactivation of [[Tumor suppressor gene|tumor suppressor genes]] such as [[P53 (protein)|p53]], [[P16 (gene)|p16]], ''p27CIP1'' and [[BRCA2]]. Oncogenes such as [[Ras]] [[oncogene|,]] [[Cyclooxygenase|Cox]]-2, [[AKT|Akt]]-2, [[Notch]] [[gene|and]] [[Cyclin D1]] may undergo activation and lead to the development of [[pancreatic cancer]]. Deregulation and crosstalk between different [[Signal transduction|signal transduction pathways]] due to [[Genomic|genomic alterations]] also have a proven role in the causation of [[Pancreatic cancer|pancreatic cance]]<nowiki/>r. | [[Pancreatic cancer]] may be caused by the inactivation of [[Tumor suppressor gene|tumor suppressor genes]] such as [[P53 (protein)|p53]], [[P16 (gene)|p16]], ''p27CIP1'' and [[BRCA2]]. [[Oncogenes]] such as [[Ras]] [[oncogene|,]] [[Cyclooxygenase|Cox]]-2, [[AKT|Akt]]-2, [[Notch]] [[gene|and]] [[Cyclin D1]] may undergo activation and lead to the development of [[pancreatic cancer]]. Deregulation and crosstalk between different [[Signal transduction|signal transduction pathways]] due to [[Genomic|genomic alterations]] also have a proven role in the causation of [[Pancreatic cancer|pancreatic cance]]<nowiki/>r. | ||
==Causes== | ==Causes== | ||
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**Inactivation of [[Tumor suppressor gene|tumor suppressor genes]] | **Inactivation of [[Tumor suppressor gene|tumor suppressor genes]] | ||
**Activation of [[Oncogene|oncogenes]] | **Activation of [[Oncogene|oncogenes]] | ||
**Deregulation of molecules in various [[Signal transduction|signaling pathways]] | **Deregulation of [[molecules]] in various [[Signal transduction|signaling pathways]] | ||
*Inactivation of tumor suppressor genes: | *Inactivation of tumor suppressor genes: | ||
| Line 34: | Line 34: | ||
***[[Cyclin D1]] | ***[[Cyclin D1]] | ||
*Deregulation of molecules in various [[Signal transduction|signaling pathways]]: | *Deregulation of [[molecules]] in various [[Signal transduction|signaling pathways]]: | ||
**[[Genomics|Genomic]] alterations of [[EGFR]] include the following: | **[[Genomics|Genomic]] alterations of [[EGFR]] include the following: | ||
***[[Deletion (genetics)|Deletion]] | ***[[Deletion (genetics)|Deletion]] | ||
Latest revision as of 13:55, 14 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Pancreatic cancer may be caused by the inactivation of tumor suppressor genes such as p53, p16, p27CIP1 and BRCA2. Oncogenes such as Ras , Cox-2, Akt-2, Notch and Cyclin D1 may undergo activation and lead to the development of pancreatic cancer. Deregulation and crosstalk between different signal transduction pathways due to genomic alterations also have a proven role in the causation of pancreatic cancer.
Causes
- Pancreatic cancer may be caused by the following:[1][2][3]
- Inactivation of tumor suppressor genes
- Activation of oncogenes
- Deregulation of molecules in various signaling pathways
- Inactivation of tumor suppressor genes:
- Tumor suppressor genes may be inactivated by:
- Tumor suppressor genes:
- Deregulation of molecules in various signaling pathways:
References
- ↑ Yabar CS, Winter JM (2016). "Pancreatic Cancer: A Review". Gastroenterol Clin North Am. 45 (3): 429–45. doi:10.1016/j.gtc.2016.04.003. PMID 27546841.
- ↑ Ryan DP, Hong TS, Bardeesy N (2014). "Pancreatic adenocarcinoma". N Engl J Med. 371 (11): 1039–49. doi:10.1056/NEJMra1404198. PMID 25207767.
- ↑ Goral V (2015). "Pancreatic Cancer: Pathogenesis and Diagnosis". Asian Pac J Cancer Prev. 16 (14): 5619–24. PMID 26320426.