Cowden syndrome surgery: Difference between revisions
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* '''[[Gastrointestinal]] [[polyps]]:''' | * '''[[Gastrointestinal]] [[polyps]]:''' | ||
** Patients with [[cowden syndrome]] should consider resection of [[gastrointestinal]] [[polyps]] [[Endoscopic|endoscopically]] which includes [[adenomatous polyps]] which are risk for developing [[colon cancer]].<ref name="pmid23238744">{{cite journal |vauthors=Levi Z, Baris HN, Kedar I, Niv Y, Geller A, Gal E, Gingold R, Morgenstern S, Baruch Y, Leach BH, Bronner MP, Eng C |title=Upper and Lower Gastrointestinal Findings in PTEN Mutation-Positive Cowden Syndrome Patients Participating in an Active Surveillance Program |journal=Clin Transl Gastroenterol |volume=2 |issue= |pages=e5 |date=November 2011 |pmid=23238744 |pmc=3365666 |doi=10.1038/ctg.2011.4 |url=}}</ref> | ** Patients with [[cowden syndrome]] should consider resection of [[gastrointestinal]] [[polyps]] [[Endoscopic|endoscopically]] which includes [[adenomatous polyps]] which are risk for developing [[colon cancer]].<ref name="pmid23238744">{{cite journal |vauthors=Levi Z, Baris HN, Kedar I, Niv Y, Geller A, Gal E, Gingold R, Morgenstern S, Baruch Y, Leach BH, Bronner MP, Eng C |title=Upper and Lower Gastrointestinal Findings in PTEN Mutation-Positive Cowden Syndrome Patients Participating in an Active Surveillance Program |journal=Clin Transl Gastroenterol |volume=2 |issue= |pages=e5 |date=November 2011 |pmid=23238744 |pmc=3365666 |doi=10.1038/ctg.2011.4 |url=}}</ref> | ||
** [[Endoscopic]] techniques like narrow band imaging should be considered for removing large [[polyps]] (≥1 cm). | ** [[Endoscopic]] techniques like narrow band imaging should be considered for removing large [[polyps]] (≥1 cm).<ref name="pmid9869523">{{cite journal |vauthors=Howe JR, Mitros FA, Summers RW |title=The risk of gastrointestinal carcinoma in familial juvenile polyposis |journal=Ann. Surg. Oncol. |volume=5 |issue=8 |pages=751–6 |date=December 1998 |pmid=9869523 |doi= |url=}}</ref> | ||
* '''Facial [[papules]]:''' | * '''Facial [[papules]]:''' | ||
Revision as of 14:51, 19 March 2019
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Cowden syndrome Microchapters |
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Cowden syndrome surgery On the Web |
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Risk calculators and risk factors for Cowden syndrome surgery |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Surgery is not the first-line treatment option for patients with cowden syndrome. Surgery is usually reserved for patients with facial papules.
Indications
- Surgery is not the first-line treatment option for patients with cowden syndrome. Surgery is usually reserved for patients with the following:
- Dysplastic Gangliocytoma:
- Keeping in mind about the potential effects of hydrocephalus like fatal herniation, resection of dysplastic gangliocytoma of the cerebellum should be considered.
- Gastrointestinal polyps:
- Patients with cowden syndrome should consider resection of gastrointestinal polyps endoscopically which includes adenomatous polyps which are risk for developing colon cancer.[1]
- Endoscopic techniques like narrow band imaging should be considered for removing large polyps (≥1 cm).[2]
References
- ↑ Levi Z, Baris HN, Kedar I, Niv Y, Geller A, Gal E, Gingold R, Morgenstern S, Baruch Y, Leach BH, Bronner MP, Eng C (November 2011). "Upper and Lower Gastrointestinal Findings in PTEN Mutation-Positive Cowden Syndrome Patients Participating in an Active Surveillance Program". Clin Transl Gastroenterol. 2: e5. doi:10.1038/ctg.2011.4. PMC 3365666. PMID 23238744.
- ↑ Howe JR, Mitros FA, Summers RW (December 1998). "The risk of gastrointestinal carcinoma in familial juvenile polyposis". Ann. Surg. Oncol. 5 (8): 751–6. PMID 9869523.